Potentialities of Induced Pluripotent Stem (iPS) Cells for Treatment of Diseases

Chakraborty, Chiranjib; Shah, Kevan; Caob, W. G.; Hsu, Chia-Yi; Wen, Zhexing; Lin, Chun‐Fu

doi:10.2174/156652410793384178

Cited by 6 publications

(3 citation statements)

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“…In addition, zebrafish have a smaller experimental area than other animals, and its genetic ease and other advantages make zebrafish models (MacRae and Peterson, 2015) provide better help for disease research. In addition, zebrafish has many advantages (Lin et al, 2023) over other model animals such as mice, such as in vitro insemination, in vitro development, rapid sexual maturation, high fecundity and low feeding cost (Chakraborty et al, 2009). Finally, zebrafish embryonic development takes place in vitro and the early embryonic body is transparent (Yalcin et al, 2017;Gore et al, 2018), making it suitable for holistic imaging and real-time in vivo observation (Lin F.-J.…”

Section: Melanin Production In Zebrafishmentioning

confidence: 99%

Zebrafish in dermatology: a comprehensive review of their role in investigating abnormal skin pigmentation mechanisms

Qu,

Yan,

Fang

et al. 2023

Front. Physiol.

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Skin pigmentation abnormalities, ranging from aesthetic concerns to severe hyperpigmentation disease, have profound implications for individuals’ psychological and economic wellbeing. The intricate etiology of hyperpigmentation and our evolving comprehension of its underlying mechanisms underscore the need for robust animal models. Zebrafish, renowned for their transparent embryos and genetic parallels to humans, have been spotlighted as a pivotal model for skin pigmentation studies. This review offers a concise overview of zebrafish skin attributes, highlighting the shared melanin production pathways with humans. We systematically dissect the diverse strategies to craft zebrafish models of abnormal skin pigmentation, spanning physical, chemical, and genetic interventions, while critically appraising the merits and constraints of each approach. Additionally, we elucidate the metrics employed to gauge the efficacy of these models. Concluding, we cast a visionary gaze on prospective breakthroughs in the domain, aiming to steer forthcoming efforts in refined zebrafish models for skin pigmentation research.

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Section: Melanin Production In Zebrafishmentioning

confidence: 99%

Zebrafish in dermatology: a comprehensive review of their role in investigating abnormal skin pigmentation mechanisms

Qu,

Yan,

Fang

et al. 2023

Front. Physiol.

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“…Some experiments using murine embryonic stem cells have shown that a knockout of DGCR8 and Dicer1, two major components of the miRNA silencing complex, causes a defect in stem cell differentiation [ 175 – 177 ]. According to Chakraborty et al, there are six major factors that are required for pluripotency maintenance, Nanog, Sox2, Oct4, KLF4, Lin28, and c-Myc [ 179 , 180 ].. MiRNA-296, miRNA-470, miRNA-134, and miRNA181a were postulated to be potential targets for these factors and to inhibit stem cells self-renewal [ 181 ].…”

Section: Role Of Emt and Met In Csc Establishment And Progressionmentioning

confidence: 99%

Differences and similarities between cancer and somatic stem cells: therapeutic implications

et al. 2020

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Over the last decades, the cancer survival rate has increased due to personalized therapies, the discovery of targeted therapeutics and novel biological agents, and the application of palliative treatments. Despite these advances, tumor resistance to chemotherapy and radiation and rapid progression to metastatic disease are still seen in many patients. Evidence has shown that cancer stem cells (CSCs), a sub-population of cells that share many common characteristics with somatic stem cells (SSCs), contribute to this therapeutic failure. The most critical properties of CSCs are their self-renewal ability and their capacity for differentiation into heterogeneous populations of cancer cells. Although CSCs only constitute a low percentage of the total tumor mass, these cells can regrow the tumor mass on their own. Initially identified in leukemia, CSCs have subsequently been found in cancers of the breast, the colon, the pancreas, and the brain. Common genetic and phenotypic features found in both SSCs and CSCs, including upregulated signaling pathways such as Notch, Wnt, Hedgehog, and TGF-β. These pathways play fundamental roles in the development as well as in the control of cell survival and cell fate and are relevant to therapeutic targeting of CSCs. The differences in the expression of membrane proteins and exosome-delivered microRNAs between SSCs and CSCs are also important to specifically target the stem cells of the cancer. Further research efforts should be directed toward elucidation of the fundamental differences between SSCs and CSCs to improve existing therapies and generate new clinically relevant cancer treatments.

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“…[18] Aufgrund der geringen Kosten, der optischen Transparenz und der hohen Reproduzierbarkeit stellen Zebrafischembryonen ein geeignetes System zur Entwicklung von Wirkstofftransporten für verschiedenste menschliche Krankheiten dar. [19] Aus diesem Grund wurde untersucht, ob unser CoiledCoil-System auch in Zebrafischembryonen funktioniert. Soweit wir wissen, wurde die Modifikation der Membran von Zebrafischen bisher noch nicht untersucht (Schema 1 C).…”

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Supramolekulare In‐vitro‐ und In‐vivo‐Funktionalisierung von Biomembranen durch ein lipidiertes Coiled‐Coil‐Bindungsmotiv

et al. 2013

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Dekoratives Design: Eine supramolekulare Methode wurde entwickelt, mit der die Oberfläche von Zellen und Zebrafischembryonen modifiziert werden kann. Zwei komplementäre Peptide bilden ein spezifisches Coiled‐Coil‐Bindungsmotiv an der Zellmembran, wodurch Liposomen in vivo und in vitro angedockt werden können (siehe Schema). Das System ist vielversprechend für die Untersuchung von biologischen Prozessen an Membranen.

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Potentialities of Induced Pluripotent Stem (iPS) Cells for Treatment of Diseases

Cited by 6 publications

References 0 publications

Zebrafish in dermatology: a comprehensive review of their role in investigating abnormal skin pigmentation mechanisms

Zebrafish in dermatology: a comprehensive review of their role in investigating abnormal skin pigmentation mechanisms

Differences and similarities between cancer and somatic stem cells: therapeutic implications

Supramolekulare In‐vitro‐ und In‐vivo‐Funktionalisierung von Biomembranen durch ein lipidiertes Coiled‐Coil‐Bindungsmotiv

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