Potentially effective natural drugs in treatment for the most common rheumatic disorder: osteoarthritis

Abstract

Osteoarthritis (OA) is a chronic condition in which imbalance between anabolic and catabolic mediators occurs leading to the destruction of homeostasis of articular cartilage. The current drugs in the management of OA can just alleviate symptoms. Hence, the research tendency toward exploration of novel sources has been grown up in order to achieve safe and efficacious drugs. Meanwhile, various components exist as novel natural drugs that may possess favorable properties for the management of OA. This review focuses on the most efficacious medicinal plants and their phytochemical agents, which have been consumed for the management of OA. Moreover, evaluation of their efficacy and molecular mechanisms of action are discussed based on numerous modern experimental investigations. More research is needed to develop therapeutic agents with disease-modifying properties to treat OA.

Evaluation of Topical Pomegranate Extracts in Management of Oral Lichen Planus: A randomized clinical trial

“…The significant decrease of total OHIP-14 values in group S and group P in comparison with group C may be attributed to the usage of topically applied pomegranates agents which enhanced collagen, DNA, and protein production along with improving contraction rate and tensile strength. As well as high levels of polyphenolic and tannin in the pomegranate extracts which accelerated wound healing through stimulation of production and movement of fibroblasts augmenting angiogenesis [27]. This is with an earlier clinical investigation which concluded that using pomegranate peel extract as a mouth wash was effective in decreasing pain and enhance wound healing in patients with RIOH [9].…”

“…Numerous patients experienced several adversative reactions with this treatment option such as candidiasis and mucosal atrophy as formerly recognized [26]. Natural-origin drugs are considered to be safe and effective replacement therapy for many disorders [27]. As a result, the current study was conducted to assess the effectiveness of pharmaceutically prepared topical pomegranate extracts gel compared to commercially available topical steroid gel as a control in management of OLP concerning sign score, grade of pain and OHRQoL in this randomized clinical trial.…”

A mechanistic review on medicinal plants used for rheumatoid arthritis in traditional Persian medicine

“…Traditional and folklore approaches for the management of diseases are among the main alternative sources of medicine. However, in spite of the growing level of tendency towards traditional medicine, evidence for safety and effectiveness of these alternative medicines is limited . Although conventional treatments of RA commonly alleviate the symptoms, high incidence of adverse reactions of these drugs has resulted in exploration of alternative methods, particularly traditional remedies, for symptomatic relief of RA.…”

Tea Polyphenols as Natural Products for Potential Future Management of HIV Infection - an overview

“…This comprises antioxidant, antibacterial, antiviral, anti-allergic, anti-colitis, anti-inflammatory, anti-arthritic and anti-cancer activities [21][22][23][24][25] . Among several polyphenol sources in the human diet, tea is one of the most consumed beverages around the world as a result of the pleasant taste, attractive aroma and health-promoting effects.…”