Potentially inappropriate medications in older kidney transplant recipients: a Brazilian prevalence study

Costa, Iwyson Henrique Fernandes da; Silva, Renan Morais E; Carlos, Juliana de Oliveira; Silva, Maria Cleonice Araújo; Pinheiro, Maria K.; Martins, Bruna Cristina Cardoso; Fernandes, Paula Frassinetti Castelo Branco Camurça; Guedes, Marjorie Moreira

doi:10.1007/s11096-019-00842-2

Cited by 7 publications

(15 citation statements)

References 30 publications

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“…486 participants in our study encountered HRPOMs related to chronic 25,26 whereas few literature showed the prevalence of PIM in surgical patients was from 42.3% to 77.6%. [27][28][29] The HRPOM list for the elderly complies well with previously published PIM criteria. HRPOMs generally included two supercategories in our study, drugs related to surgery such as analgesics, anesthetics, sedatives and anti-infective agents and drugs related to chronic non-communicable diseases such as antihypertensives, hypoglycemics and antimyocardial ischemia agents.…”

Section: Discussionmentioning

confidence: 84%

“…45 This provides further evidence to previous studies that more medications mean more risks. 4,[26][27][28][29]31 Given the poor health status and medication adherence, the elderly on polypharmacy are at higher risk of adverse drug events than the population of younger age or/and without polypharmacy. 46 The days of hospital stay were usually regarded as one of the hospitalization outcomes, while in our study this variable also contributed to HRPOMs.…”

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confidence: 99%

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High-Risk Perioperative Medications in the Chinese Elderly Population

Wang

Ren

Tan

et al. 2021

CIA

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Background: Inappropriate perioperative medications among elderly patients increase the risk of adverse events and undermine surgical outcomes. This study aimed to assess the prevalence of high-risk medications in elderly surgical patients and verify the effectiveness of a new-developed high-risk perioperative medications (HRPOMs) list for the elderly. Methods: A cross-sectional, single-center study was conducted at Jinshan Hospital of Fudan University. A total of 810 elderly surgical patients were included in the study. The HRPOMs list was applied to patients' data to identify the HRPOMs including chronic medications and medications related to surgery. Results: A total of 2113 HRPOMs were identified in 810 patients who fulfilled the inclusion criteria. Of these, 1067 (50.5%) involved medications related to surgery, and 982 (46.5%) involved chronic medications. The prevalence of HRPOM exposure, which was defined as at least one HRPOM was 76.3%. Patients that were 70 years or older (adjusted odds ratio [AOR] =2.118, 95% confidence interval [CI], 1.420~3.159), hospitalized over two weeks (AOR =4.192, 95% CI, 1.493~11.771), with more than 2 distinct diagnoses (AOR =3.407, 95% CI, 2.224~5.220) and with 16 or more medications during hospitalization were more likely to be exposed to HRPOMs. Patients who underwent surgeries of Grade IV were at 1.73 increased odds of HRPOM exposure compared with those who received surgeries of Grade III or lower (P=0.071). Conclusion:HRPOMs are more common in patients of 70 years or older, with 3 or more distinct diagnoses, with 16 or more medications and hospitalized for 15 days or longer. Our study showed the validity of the HRPOMs list in the perioperative medication review for the elderly and may induce further research to reveal the impact of HRPOMs upon the surgical outcomes of the elderly.

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Section: Discussionmentioning

confidence: 84%

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confidence: 99%

High-Risk Perioperative Medications in the Chinese Elderly Population

Wang

Ren

Tan

et al. 2021

CIA

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“…The reported duration for self-medication prevalence varied between the moment of the study[ 25 26 27 28 29 30 31 32 33 34 35 36 37 ] and two years[ 38 ] in the cross-sectional studies and about two decades in a case report. [ 39 ] Except for 6 case reports that reported self-medication in the elderly, 17 cross-sectional studies included only individuals above 60 years old,[ 26 27 29 30 31 36 38 40 41 42 43 44 45 46 47 48 49 ] and others considered both the young and the elderly. Of the 38 cross-sectional studies, 37 included women and men, and 1 considered only men.…”

Section: Resultsmentioning

confidence: 99%

“…[ 50 ] Sample sizes ranged from 1 in case reports to 31,672 in a study on the elderly in 14 European countries. [ 45 ] Of the 44 selected studies, the majority were carried out in the Americas: 7 in USA,[ 38 44 51 52 53 54 55 56 ]11 in Brazil,[ 26 27 30 34 40 47 50 57 58 59 60 61 ] and 2 in Peru. [ 28 37 ] Twelve studies were conducted in Asia.…”

Section: Resultsmentioning

confidence: 99%

Prevalence of self-medication among the elderly: A systematic review and meta-analysis

Rafati

Baniasadi

Dastyar

et al. 2023

Journal of Education and Health Promotion

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BACKGROUND: Self-medication is the use of unprescribed drugs to treat a disease. Elderly self-medication can be more dangerous compared to other age groups because of changes in organ functions that occur due to senescence. This study aimed to estimate the prevalence of self-medication in the elderly, its related factors, and common drugs used in this regard. MATERIALS AND METHODS: Electronic databases such as PubMed, Scopus, and Web of Science were searched between January 2016 and June 2021. The search strategy was built on two core concepts: “self-medication” and “aged”. The search was limited to original articles in the English language. A random effect model was used to estimate the pooled prevalence of self-medication. Heterogeneity among studies was assessed using both the I2 statistic and the χ2 test. Also, a meta-regression model was used to investigate the potential sources of heterogeneity of the studies. RESULTS: Out of 520 non-duplicate studies, 38 were included in the meta-analysis. Self-medication in the elderly ranged from 0.3% to 82%. The pooled proportion of self-medication was 36% (95% CI: 27%–45%). The result of the χ2 test and the I2 index (P < 0.001, I2 = 99.90%) revealed notable heterogeneity among the included studies in the meta-analysis. The meta-regression showed a significant association between the sample size (adjusted β = −0.01; P = 0.043) and the pooled proportion of self-medication. CONCLUSION: The prevalence of self-medication in the elderly is high. Education through mass media to raise awareness about the dangers of self-medication can help solve this problem.

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“…Tanto a população de idosos como a de outros pacientes com doenças crônicas como os pacientes com doença renal crônica, transplantados renais, hipertensos, com problemas cardiovasculares e diabéticos que utilizam vários medicamentos são mais susceptível a falhas, durante o percurso pelos pontos de transição do cuidado (BREUKER et al, 2017;COSTA et al, 2019;Boletim ISMP, 2019;OBRY et al, 2018). O ISMP-Brasil preconiza a necessidade de melhorias no processo de saúde, dando credibilidade ao processo de conciliação de medicamentos (Boletim ISMP, 2019).…”

Section: Fatores Que Contribuem Com a Falha Da Terapia De Medicamentosunclassified

Conciliação de medicamentos na admissão hospitalar para a segurança do paciente: uma revisão / Reconciliation of medications at hospital admission for patient safety: a review

Brito¹,

Veloso²,

Fernandes³

et al. 2022

Braz. J. Hea. Rev.

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Potentially inappropriate medications in older kidney transplant recipients: a Brazilian prevalence study

Cited by 7 publications

References 30 publications

High-Risk Perioperative Medications in the Chinese Elderly Population

High-Risk Perioperative Medications in the Chinese Elderly Population

Prevalence of self-medication among the elderly: A systematic review and meta-analysis

Conciliação de medicamentos na admissão hospitalar para a segurança do paciente: uma revisão / Reconciliation of medications at hospital admission for patient safety: a review

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