Potentially inappropriate medicines in elderly hospitalised patients according to the EU(7)-PIM list, STOPP version 2 criteria and comprehensive protocol

Mucalo, Iva; Hadžiabdić, Maja Ortner; Brajković, Andrea; Lukić, Sonja; Marić, Patricia; Marinović, Ivana; Bačić-Vrca, Vesna

doi:10.1007/s00228-017-2246-y

Cited by 40 publications

(59 citation statements)

References 48 publications

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“…The study population comprised patients discharged from a single medical unit in one hospital and therefore results may not be generalizable to other settings. However, the observed prevalence of PIMs and PPOs in our study is comparable to those reported by others in different patient groups .…”

Section: Discussionsupporting

confidence: 90%

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Hospital readmissions, mortality and potentially inappropriate prescribing: a retrospective study of older adults discharged from hospital

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Millar

McLay

2018

Brit J Clinical Pharma

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Section: Discussionsupporting

confidence: 90%

“…The higher reported prevalence in the inpatient setting is likely a reflection of greater co‐morbidity and prescription medication burden. Our finding that 59.1% of the study population were subject to one or more PIMs is similar to the proportion reported by others applying version 2 of the STOPP criteria in the inpatient setting .…”

Section: Discussionsupporting

confidence: 90%

Hospital readmissions, mortality and potentially inappropriate prescribing: a retrospective study of older adults discharged from hospital

Counter

Millar

McLay

2018

Brit J Clinical Pharma

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“…In keeping with previous studies, benzodiazepines and PPI were the most frequent PIM in our sample . Interestingly, in our sample, PPI inappropriateness was more often related to the lack of an evidence‐based indication (STOPP A1), rather than to an inappropriate duration of appropriate therapy (STOPP F2).…”

Section: Discussionsupporting

confidence: 89%

“…The results of the present study are in keeping with those reported in two recent studies carried out in hospital‐discharged patients. Among 276 patients (mean age 74 years) discharged from an internal medicine department, Mucalo et al reported a PIM prevalence of 68.8%; mainly represented by benzodiazepines and PPI . In a sample of 319 patients (mean age 69 years) discharged from the cardiology and internal medicine departments of an Albanian hospital, 63.0% of patients presented at least one PIM, a figure similar to what we detected among internal medicine‐discharged patients (63.8%) .…”

Section: Discussionsupporting

confidence: 82%

Prevalence and predictors of inappropriate prescribing according to the Screening Tool of Older People's Prescriptions and Screening Tool to Alert to Right Treatment version 2 criteria in older patients discharged from geriatric and internal medicine wards: A prospective observational multicenter study

Gibello

Brunetti

et al. 2018

Geriatrics Gerontology Int

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Aim To evaluate the prevalence and predictors of potentially inappropriate medications (PIM) and potential prescribing omissions (PPO) in hospital‐discharged older patients, according to the recently updated Screening Tool of Older People's Prescriptions and Screening Tool to Alert to Right Treatment version 2 criteria. Methods This was a multicenter prospective observational study of patients aged ≥65 years consecutively discharged from geriatric and internal medicine wards. Each patient underwent a comprehensive geriatric assessment, and PIM and PPO at discharge were determined according to the Screening Tool of Older People's Prescriptions and Screening Tool to Alert to Right Treatment version 2 criteria. A multivariate logistic regression was carried out to identify variables independently associated with PIM and PPO. Results Among 726 participants (mean age 81.5 years, 47.8% women), the prevalence of PIM and PPO were 54.4% and 44.5%, respectively. Benzodiazepines and proton‐pump inhibitors were the drugs most frequently involved with PIM, whereas PPO were often related to 5‐alpha reductase inhibitors, angiotensin‐converting enzyme inhibitors, statins and drugs for osteoporosis. The number of medications (OR 1.22, 95% CI 1.15–1.28) and discharge from geriatric units (OR 0.55, 95% CI 0.40–0.75) were associated with PIM, whereas PPO were independently associated with discharge from geriatric wards (OR 0.44, 95% CI 0.31–0.62), age (OR 1.04, 95% CI 1.02–1.07), comorbidities (OR 1.17, 95% CI 1.04–1.30) and the number of drugs (OR 1.12, 95% CI 1.05–1.18). Conclusions Inappropriate prescribing is highly prevalent among hospital‐discharged older patients, and is associated with polypharmacy and discharge from internal medicine departments. Geriatr Gerontol Int 2019; 19: 5–11.

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“…Meanwhile, a retrospective cohort study carried out in long‐term care facilities reported that patients with PIM based on Beers Criteria 2012 comprised 37.5% of study patients . STOPP criteria version 2 has been reported to detect more PIM than Beers Criteria 2012, the European Union (7)‐PIM list and the comprehensive protocol . The proportion of patients with PIM based on STOPP‐J in the present study was higher than that based on STOPP criteria version 2 and the results of the other study using STOPP criteria version 2 and Beers Criteria 2012 .…”

Section: Discussioncontrasting

confidence: 55%

Efficacy of pharmacists' assessment and intervention based on Screening Tool for Older Persons' Appropriate Prescriptions for Japanese compared with Screening Tool for Older Persons' Appropriate Prescriptions for Japanese criteria version 2 in older patients with cardiovascular disease

Kondo

Ogura

Kukita

et al. 2019

Geriatrics Gerontology Int

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Aim This study aimed to evaluate the efficacy of pharmacists' assessment and intervention using the Screening Tool for Older Persons' Appropriate Prescriptions for Japanese (STOPP‐J) to detect and correct potentially inappropriate medications (PIM) compared with the Screening Tool of Older Persons' Potentially Inappropriate Prescriptions (STOPP) criteria version 2. Methods A prospective observational study was carried out at a medical unit of Cardiovascular Surgery and Cardiovascular Internal Medicine in a Japanese university hospital involving new inpatients aged ≥65 years prescribed one or more daily medication. Pharmacists detected PIM based on STOPP‐J and STOPP criteria version 2, and corrected them with physicians. The number of patients with PIM, the content and changes in PIM were compared between both criteria. Results Overall, 230 patients were included (mean age 75.4 years, 162 men, mean number of medications 8.3). STOPP‐J detected significantly more patients with PIM than STOPP criteria version 2 (122 [53%] vs 75 [33%], P < 0.001). The number of PIM based on STOPP‐J was 232, the physicians were recommended to change 61 (26%) and 50 (22%) were changed. Meanwhile, the number of PIM based on STOPP criteria version 2 was 133, the physicians were recommended to change 61 (46%) and 54 (41%) were changed. Several medications detected as PIM using STOPP‐J were not detected using STOPP criteria version 2. Conclusions STOPP‐J detected significantly more patients with PIM than STOPP criteria version 2, and pharmacists' assessment and intervention based on STOPP‐J were suggested to be effective for detecting and correcting PIM. Geriatr Gerontol Int 2019; 19: 1101–1107.

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Potentially inappropriate medicines in elderly hospitalised patients according to the EU(7)-PIM list, STOPP version 2 criteria and comprehensive protocol

Abstract: A very high PIM prevalence at discharge was reported suggesting the urgent need for actions to reduce them. STOPP version 2 criteria identified significantly more PIMs than the EU(7)-PIM list and the comprehensive protocol and was found as a more sensitive tool for PIM detection.

Cited by 40 publications

References 48 publications

Hospital readmissions, mortality and potentially inappropriate prescribing: a retrospective study of older adults discharged from hospital

Hospital readmissions, mortality and potentially inappropriate prescribing: a retrospective study of older adults discharged from hospital

Efficacy of pharmacists' assessment and intervention based on Screening Tool for Older Persons' Appropriate Prescriptions for Japanese compared with Screening Tool for Older Persons' Appropriate Prescriptions for Japanese criteria version 2 in older patients with cardiovascular disease

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