Potentially inappropriate prescribing in community-dwelling older people across Europe: a systematic literature review

Tommelein, Eline; Mehuys, Els; Petrovic, Mirko; Somers, Annemie; Colin, Pieter; Boussery, Koen

doi:10.1007/s00228-015-1954-4

Cited by 252 publications

(282 citation statements)

References 91 publications

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“…Moreover, we added 3 criteria (assessing potentially inappropriate prolonged use of medications) to those of the Laroche list, which happened to increase by nearly 10% the prevalence of PIMs. Consistently with the review by Tommelein et al [23], we found benzodiazepines and NSAIDs among the most reported PIMs. Conversely, inappropriate use of antidepressants was limited in our study.…”

Section: Prevalence Of Polypharmacy and Pimssupporting

confidence: 93%

“…Our estimates of the prevalence of polypharmacy and PIMs are relatively high compared to previous estimates [7,9,11,23], which was expected considering our methodology. Indeed, the prevalence of polypharmacy should be considered with regard to our definition that encompasses all the medications prescribed over 3-month periods.…”

Section: Prevalence Of Polypharmacy and Pimssupporting

confidence: 62%

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Frailty, polypharmacy, and potentially inappropriate medications in old people: findings in a representative sample of the French population

Herr

Sirven

Grondin

et al. 2017

Eur J Clin Pharmacol

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Results: The study population was composed of 1003 women and 887 men, of mean age 74.7 +/-7.4 years. Polypharmacy (5 to 9 drugs) and excessive polypharmacy (≥10 drugs) were reported in 42.9% and 27.4% of the study population respectively, while 46.7% of the study population received at least one PIM during the year 2012. Polypharmacy and PIMs were both associated with the number of frailty criteria in models adjusted for socio-demographic and health characteristics of the participants. The prescription of anticholinergic medications was the only PIM that remained significantly associated with the number of frailty criteria after adjustment for polypharmacy.Conclusions: Polypharmacy and use of anticholinergic medications are independently associated with frailty in old people.3

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Section: Prevalence Of Polypharmacy and Pimssupporting

confidence: 93%

Section: Prevalence Of Polypharmacy and Pimssupporting

confidence: 62%

Frailty, polypharmacy, and potentially inappropriate medications in old people: findings in a representative sample of the French population

Herr

Sirven

Grondin

et al. 2017

Eur J Clin Pharmacol

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“…Moreover, polypharmacy is associated with poor adherence, lower physical and social function, higher healthcare costs, and decreased quality of life [13,16,19]. Additionally, inappropriate prescribing, including both over-(potentially inappropriate prescribing [PIP]) and underprescription (potential prescribing omission [PPO]) is also associated with poor outcome, such as increase in adverse drug events [21]. While polypharmacy is relatively well defined, the definition of multimorbidity is not consistent in the literature; a common definition is 2 or more comorbidities [3].…”

Section: Introductionmentioning

confidence: 98%

Polypharmacy and specific comorbidities in university primary care settings

Aubert¹,

Streit²,

Costa³

et al. 2016

European Journal of Internal Medicine

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“…Some researches related to polypharmacy used this classification system 12. ATC classification contains all kinds of medications and we can interpret each classification as those effects in the body.…”

Section: Methodsmentioning

confidence: 99%

Are the kind of medications and patient's background associated with improving polypharmacy in elderly?

Tomita

Kobayashi

Hayashi

et al. 2018

J of Gen and Family Med

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BackgroundPolypharmacy is associated with negative outcomes in older population. Managing polypharmacy is important but there is no definite method for regulating it. Our aim was to evaluate what medications and patient's background are associated with reducing polypharmacy.MethodsA prospective, single‐center, cohort study was conducted from June to October in 2016. Participants were 65 and older hospitalized patients. We evaluated the difference between the numbers of medications used at the time of admission and discharge for individual drug class. Univariate analyses using paired t tests were applied to evaluate reduction in prescription medications, and logistic regression was used to evaluate factors for any reduction of prescription medications used at discharge.ResultsThere were 494 subjects, and the mean of age was 79.6 ± 7.8 years. The mean number of medications used at admission was 6.9 ± 4.7 and that at discharge was 6.8 ± 4.3. The types of medications that reduced between admission and discharge were drugs for functional gastrointestinal disorders and agents acting on the renin‐angiotensin system, etc. Individual components that were strongly associated with a reduction of the number of medications used were only length of hospital stay (OR 0.99, 95% CI, 0.99‐1.0), while the number of medications on admission was related to increasing medication during hospitalization (OR 1.05, 95% CI, 1.01‐1.06).ConclusionsMost of the kinds and the number of medications prescribed might not be changed during hospitalization despite those were probably the causes of admission. The factor associated with improvements in polypharmacy was length of hospital stay.

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Potentially inappropriate prescribing in community-dwelling older people across Europe: a systematic literature review

Abstract: PIP prevalence in European community-dwelling older adults is high and depends partially on the data collection method used. Polypharmacy, poor functional status, and depression were identified as the most common risk factors for PIP.

Cited by 252 publications

References 91 publications

Frailty, polypharmacy, and potentially inappropriate medications in old people: findings in a representative sample of the French population

Frailty, polypharmacy, and potentially inappropriate medications in old people: findings in a representative sample of the French population

Polypharmacy and specific comorbidities in university primary care settings

Are the kind of medications and patient's background associated with improving polypharmacy in elderly?

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