Potentially lethal <scp>ACE</scp>‐inhibitor‐induced angioedema in a child

Bukhari, Esraa; Safdar, Osama Y; Shalaby, Mohamed; Alsharif, Shafiqa; Alsufiany, Khoulod; Kari, Jameela A.

doi:10.1002/ccr3.265

Cited by 6 publications

(3 citation statements)

References 13 publications

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“…This problem is an atypical occurrence in Saudi Arabia, as only one case has been reported [ 6 ]. Moreover, when we inquired of the National Pharmacovigilance and Drug Safety Center at the Saudi Food and Drug Authority regarding this, they stated that only four cases of angioedema induced by either lisinopril, captopril, or perindopril have been documented.…”

Section: Discussionmentioning

confidence: 99%

“…So far, only four cases of angioedema caused by ACE inhibitors have been reported to the National Pharmacovigilance and Drug Safety Center at the Saudi Food and Drug Authority by different hospitals in Saudi Arabia. In 2015, Bukhari et al [ 6 ] reported the first study regarding the occurrence of angioedema following administration of ACE inhibitors in a 9-year-old girl with renal disease. The rarity of this condition in Saudi Arabia may be because the predisposing factors are still unknown, although it is more common among African-American patients.…”

Section: Introductionmentioning

confidence: 99%

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Perindopril-induced angioedema of the lips and tongue: a case report

Alharbi¹,

Alharthi²,

Alsaadi³

2018

J Med Case Reports

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BackgroundAce inhibitor-induced angioedema, characterized by sudden-onset swelling of the mucous membrane, skin, or both, is a rare occurrence in the Kingdom of Saudi Arabia. Because of its safety and efficacy, perindopril is a commonly prescribed angiotensin-converting enzyme inhibitor. Here we describe the clinical manifestations, management, and outcome of perindopril-induced angioedema of the lips and tongue in a 65-year-old Saudi man.Case presentationA 65-year-old Saudi Arab man presented to an emergency department with lip and tongue swelling and dysphagia. There were no systemic symptoms and no past history of a similar event. He had been consuming perindopril 5 mg and amlodipine 5 mg for the last 3 weeks: brand name, Coveram, from the company Servier (Ireland) Industries Ltd.; one tablet of Coveram contains 3.395 mg perindopril corresponding to 5 mg perindopril arginine and 6.935 mg amlodipine besilate corresponding to 5 mg amlodipine. A physical examination revealed considerable swelling of his lips and tongue.Examinations of other systems, including his cardiovascular and respiratory systems, revealed unremarkable findings. All laboratory parameters were also normal. Electrocardiography demonstrated sinus rhythm, a normal P axis, and V-rate of 50–99.A clinical diagnosis of perindopril-induced angioedema was made, and perindopril was discontinued. The angioedema resolved completely after the administration of antihistamines and corticosteroids.ConclusionsAngioedema caused by angiotensin-converting enzyme inhibitors is an uncommon occurrence in Saudi Arabia. The findings from this case are expected to raise awareness about this condition among clinicians in this country.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Perindopril-induced angioedema of the lips and tongue: a case report

Alharbi¹,

Alharthi²,

Alsaadi³

2018

J Med Case Reports

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“…ACEI-induced angioedema (ACEI-AE) is characterized by non-pitting edema of the skin and/or mucous membranes, most commonly in the head and neck area, often involving swelling of the lips and/or tongue [1]. ACEI-AE has mainly been reported in adults, with few reports in children [2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema Following Posterior Reversible Encephalopathy Syndrome in a Child: A Case Report

Ichikawa¹,

Matsuoka²,

Murase³

et al. 2022

Cureus

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Angioedema is a rare but potentially lethal side effect of angiotensin-converting enzyme inhibitors (ACEIs). Most ACEI-induced angioedema (ACEI-AE) cases have been reported in adults, with few reports of cases in children. Posterior reversible encephalopathy syndrome (PRES) is a neurological disorder that presents with acute onset of symptoms, including headache, vomiting, visual disturbances, and seizures. We report the case of a patient who developed ACEI-AE after developing PRES during the treatment of steroid-resistant nephrotic syndrome. ACEI-AE is very rare, especially in children, but can be life-threatening if swelling of the tongue or the throat blocks the airway. Whenever ACEIs are used, even in children, clinicians should be aware of the possibility of the occurrence of ACEI-AE, particularly when accompanied by dry cough. Moreover, bradykinin may be associated with PRES onset in patients with ACEI-AE and may be a risk factor for PRES.

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Hypersensitivity Reactions to Drugs

Abu-Hilal

Shear

2019

Harper's Textbook of Pediatric Dermatology

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Potentially lethal ACE‐inhibitor‐induced angioedema in a child

Cited by 6 publications

References 13 publications

Perindopril-induced angioedema of the lips and tongue: a case report

Perindopril-induced angioedema of the lips and tongue: a case report

Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema Following Posterior Reversible Encephalopathy Syndrome in a Child: A Case Report

Hypersensitivity Reactions to Drugs

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