Potentially preventable tuberculosis cases in children exposed to a contaminant case

Ollier, Vincent; Antoun, F.; Thouvenin, Guillaume; Faye, Albert; Koné‐Paut, Isabelle; Benoist, G.; Antoine, D; Charlois, Cécile; Delacourt, Christophe

doi:10.1016/j.arcped.2018.07.001

Cited by 5 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Policies on the pragmatic management of TB infection are still not adequately implemented [24]. A French study confirmed that a large proportion of cases of TB in children could have been prevented by timely screening after exposure and appropriate prescription of a preventive treatment [25]. According to a mathematical modelling study, implementation of systematic contact investigation for exposed children and prescription of prophylactic treatment if indicated could prevent more than 150,000 cases of TB disease and 100,000 deaths from TB in children below the age of 15 years each year, worldwide [26].…”

Section: Discussionmentioning

confidence: 99%

Tuberculosis Case Detection and Guideline Adherence among Child Contacts in Switzerland: A Retrospective Observational Study

Gasser,

Fritschi,

Egger

et al. 2023

Respiration

View full text Add to dashboard Cite

Background: Children exposed to a tuberculosis (TB) index case are at risk of TB infection and disease. Objectives: The aim of this study was to describe the proportion of child contacts who developed TB infection or disease after exposure and to assess the diagnostic pathways and adherence to current guidelines. Methods: Retrospective observational study including children ≤16 years of age who had contact to a TB index case between January 2019 and July 2021. Analysis was stratified by age groups 0–4, 5–11, and 12–16 years. Results: Of 401 TB-exposed children, data were available for 380 (95%). Of those, 7 (2%) were diagnosed with TB disease and 35 (9%) with TB infection. We identified several deviations in the management compared to recommendations in national Swiss guidelines: In the children aged 0–4 years, only 82% were examined with an immunodiagnostic test or a chest radiography within 2 weeks after last contact. Recommended prophylactic treatment was prescribed in 66% of the children only. In the children aged 5–11 years, 64% were tested with an immunodiagnostic test in a first examination and 75% in a second examination, 2 weeks and 2 months after last contact, respectively. Conclusions: Contact investigations of children exposed to a TB index case identified a significant proportion of children with TB infection and disease in a low TB incidence setting. We observed significant deviations from the guidelines in the contact investigations suggesting the need for improved implementation.

show abstract

Section: Discussionmentioning

confidence: 99%

Tuberculosis Case Detection and Guideline Adherence among Child Contacts in Switzerland: A Retrospective Observational Study

Gasser,

Fritschi,

Egger

et al. 2023

Respiration

View full text Add to dashboard Cite

show abstract

“…In order to overcome missed opportunities to prevent active TB, strengthening of healthcare networks by involving physicians included in screening procedures, education for families, medical training, and development of shared and computerized tools to improve data completeness, communication, and follow-up of patients have been suggested. 4 Communication between hospital departments and community services is also desirable.…”

mentioning

confidence: 99%