Potentially toxic elements (PTEs) associated with asbestos chrysotile, tremolite and actinolite in the Calabria region (Italy)

Bloise, Andrea; Ricchiuti, Claudia; Punturo, Rosalda; Pereira, Dolores

doi:10.1016/j.chemgeo.2020.119896

Cited by 22 publications

(13 citation statements)

References 96 publications

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“…Sr has been previously reported as a potential toxic element (PTE) present in trace quantities in various types of asbestos, with a key role in MPM pathogenesis. 27 One group has found high amounts of Sr, among other contaminants, in the hair samples of subjects environmentally exposed to crocidolite asbestos. 28 However, quantitative analysis is further required to correctly classify the impurities in the investigated samples as crocidolite.…”

Section: Resultsmentioning

confidence: 99%

“…Asbestos bodies are not inert structures and are known to trigger endogenous metal mobilization across the tissue, most noteworthily of iron and copper. 13 Iron sequestration by the malignant cells can be noted in Figure 2 , panel D. Apart from the endogenous Cu known to coat asbestos fibers, Cu has been classified as an asbestos contaminant, also known as a PTE due to its abilities to increase the toxic character of asbestos fibers in a synergistic manner, 27 , 30 which can be noted in Figure 2 , panel E. Zinc levels also appeared to be elevated, with counts nearly twice as high as those of the rest of subjects ( Figure S7 ). Zn is overabundant in the cancer tissue containing aggressive malignant cells in contrast to normal stroma.…”

Section: Resultsmentioning

confidence: 99%

“…A noteworthy finding was the high amount of strontium yielded by two out of the three impurities present in the ROI and indicated by the white arrows (Figure , panel H). Sr has been previously reported as a potential toxic element (PTE) present in trace quantities in various types of asbestos, with a key role in MPM pathogenesis . One group has found high amounts of Sr, among other contaminants, in the hair samples of subjects environmentally exposed to crocidolite asbestos .…”

Section: Resultsmentioning

confidence: 99%

“…Interestingly, high levels of strontium, a PTE, were yielded by the impurities present in these samples following ablation. Strontium is not a commonly reported asbestos impurity, and there is limited research regarding its role in MPM onset and pathogenesis. , Monitoring the metallome around the talc deposits offered insights into the impact talc pleurodesis has on tissues, and it is important to assess if the therapeutic benefits really outweigh the risks. The presence of talc particulates led to a significant increase in tissue damage and inflammation, as reflected by the high Fe signals, which were up to 10× higher than that for the rest of subjects.…”

Section: Discussionmentioning

confidence: 99%

“…Possible impurities are indicated by white arrows. Signal intensity maps of (B)23 Na + , (C) 26 Mg + , (D)27 Al + , (E)28 Si + , (F) 31 P + , (G) 56 Fe + , and (H) 64 Zn + , obtained by LA−ICP−TOFMS imaging.…”

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Elemental Mapping of Human Malignant Mesothelioma Tissue Samples Using High-Speed LA–ICP–TOFMS Imaging

et al. 2022

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This is the first report of the use of laser ablation–inductively coupled plasma time-of-flight mass spectrometry (LA–ICP–TOFMS) to analyze human malignant pleural mesothelioma (MPM) samples at the cellular level. MPM is an aggressive, incurable cancer associated with asbestos exposure, with a long latency and poor overall survival. Following careful optimization of the laser fluence, the simultaneous ablation of soft biological tissue and hard mineral fibers was possible, allowing the spatial detection of elements such as Si, Mg, Ca, and Fe, which are also present in the glass substrate. A low-dispersion LA setup was employed, which provided the high spatial resolution necessary to identify the asbestos fibers and fiber fragments in the tissue and to characterize the metallome at the cellular level (a pixel size of 2 μm), with a high speed (at 250 Hz). The multielement LA–ICP–TOFMS imaging approach enabled (i) the detection of asbestos fibers/mineral impurities within the MPM tissue samples of patients, (ii) the visualization of the tissue structure with the endogenous elemental pattern at high spatial resolution, and (iii) obtaining insights into the metallome of MPM patients with different pathologies in a single analysis run. Asbestos and other mineral fibers were detected in the lung and pleura tissue of MPM patients, respectively, based on their multielement pattern (Si, Mg, Ca, Fe, and Sr). Interestingly, strontium was detected in asbestos fibers, suggesting a link between this potential toxic element and MPM pathogenesis. Furthermore, monitoring the metallome around the talc deposit regions (characterized by elevated levels of Al, Mg, and Si) revealed significant tissue damage and inflammation caused by talc pleurodesis. LA–ICP–TOFMS results correlated to Perls’ Prussian blue and histological staining of the corresponding serial sections. Ultimately, the ultra-high-speed and high-spatial-resolution capabilities of this novel LA–ICP–TOFMS setup may become an important clinical tool for simultaneous asbestos detection, metallome monitoring, and biomarker identification.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Elemental Mapping of Human Malignant Mesothelioma Tissue Samples Using High-Speed LA–ICP–TOFMS Imaging

et al. 2022

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Natural occurrence of asbestos in serpentinite quarries from Southern Spain

Bloise

Ricchiuti

Navarro

et al. 2021

Environ Geochem Health

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The Nevado-Filábride Complex (NFC) area (southern Spain) is well known for the widespread mining and quarrying activities. Serpentinite and metabasite rock types are extracted, processed and traded as building and ornamental stones. Due to possible presence of Naturally Occurring Asbestos (NOA) minerals in these lithotypes, the aim of the investigation of this paper is to discern about the presence of these fibrous minerals and to characterize them in detail. In order to do this, seven serpentinite rock samples were collected in four quarries located in Sierra Nevada and Sierra de los Filabres (South-eastern Spain) and studied by X-ray powder diffractometry (XRPD), Scanning Electron Microscopy combined with Energy-Dispersive Spectrometry (SEM/EDS), Differential scanning calorimetry (DSC), Derivative Thermogravimetry (DTG) and by X-ray Synchrotron microtomography (SR-µCT). The investigation of asbestos minerals is very important not only from a scientific point of view, but also from a legislative one, especially for the administrative agencies that have to take decisions with regards to the implementation of health protection to workers (e. g., quarry excavations, road yards, civil constructions, building stones).

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Geological and mineralogical characterization of fibrous tremolite from Iacolinei quarry (Basilicata, Italy)

Pacella,

Ballirano,

Di Carlo

et al. 2024

Environ Geochem Health

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Potentially toxic elements (PTEs) associated with asbestos chrysotile, tremolite and actinolite in the Calabria region (Italy)

Cited by 22 publications

References 96 publications

Elemental Mapping of Human Malignant Mesothelioma Tissue Samples Using High-Speed LA–ICP–TOFMS Imaging

Elemental Mapping of Human Malignant Mesothelioma Tissue Samples Using High-Speed LA–ICP–TOFMS Imaging

Natural occurrence of asbestos in serpentinite quarries from Southern Spain

Geological and mineralogical characterization of fibrous tremolite from Iacolinei quarry (Basilicata, Italy)

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