Potentiating Antitumor Efficacy Through Radiation and Sustained Intratumoral Delivery of Anti-CD40 and Anti-PDL1

Liu, Hsuan-Chen; Viswanath, Dixita I.; Pesaresi, Federica; Xu, Yitian; Zhang, Licheng; Trani, Nicola Di; Paez‐Mayorga, Jesus; Hernandez, Nathanael; Wang, Yu; Erm, Donald R.; Ho, Jeremy; Susnjar, Antonia; Liu, Xuewu; Demaria, Sandra; Chen, Shu‐Hsia; Teh, Bin S.; Butler, E. Brian; Chua, Corrine Ying Xuan; Grattoni, Alessandro

doi:10.1016/j.ijrobp.2020.07.2326

Cited by 51 publications

(47 citation statements)

References 60 publications

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“…Our results suggest a significant dose-dependency effect on cell viability and a time-dependent cytotoxicity effect as a function of surfactant charge for both cell lines. As strategies and technologies to improve local delivery of agents for cancer treatment are emerging, [72][73][74][75] there is a greater need to better characterize nanoparticles to understand their interactions with cancerous cells. The results of this study can aid in the design of future theranostic applications for oncological translation.…”

Section: Discussionmentioning

confidence: 99%

Improvements in Gold Nanorod Biocompatibility with Sodium Dodecyl Sulfate Stabilization

Terracciano¹,

Zhang²,

Simeral³

et al. 2021

Preprint

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Due to their well-defined plasmonic properties, gold nanorods (GNRs) can be fabricated with optimal light absorption in the near-infrared region of the electromagnetic spectrum, which make them suitable for cancer-related theranostic applications. However, their controversial safety profile, as a result of surfactant stabilization during synthesis, limits their clinical translation. We report a facile method to improve GNR biocompatibility through the presence of sodium dodecyl sulfate (SDS). GNRs (120 x 40 nm) were synthesized through a seed-mediated approach, using cetyltrimethylammonium bromide (CTAB) as a cationic surfactant to direct the growth of nanorods and stabilize the particles. Post-synthesis, SDS was used as an exchange ligand to modify the net surface charge of the particles from positive to negative while maintaining rod stability in an aqueous environment. GNR cytotoxic effects, as well as the mechanisms of their cellular uptake, were examined in two different cancer cell lines, Lewis lung carcinoma (LLC) and HeLa cells. We not only found a significant dose-dependent effect of GNR treatment on cell viability but also a time-dependent effect of GNR surfactant charge on cytotoxicity over the two cell lines. Our results promote a better understanding of how we can mediate the undesired consequences of GNR synthesis byproducts when exposed to a living organism, which so far has limited GNR use in cancer theranostics.

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Section: Discussionmentioning

confidence: 99%

Improvements in Gold Nanorod Biocompatibility with Sodium Dodecyl Sulfate Stabilization

Terracciano¹,

Zhang²,

Simeral³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…In recent years, intratumoral injection has begun to arouse the interest of scholars because of its ability to directly enrich the drug in the tumor [ 16 ]. Local delivery of chemotherapy, in combination with immunotherapy, elicits systemic response against cancer and eliminates the challenges of poor drug targeting from intravenous administration [ 17 , 18 , 19 ]. However, its disadvantage is also obvious, and it is only suitable for superficial tumors rather than deeper tumors.…”

Section: Introductionmentioning

confidence: 99%

Chondroitin Sulfate-Modified Liposomes for Targeted Co-Delivery of Doxorubicin and Retinoic Acid to Suppress Breast Cancer Lung Metastasis

Zhang

Luo

2021

Pharmaceutics

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Breast cancer treatment remains challenging due to high levels of cell metastasis. Chemotherapy drug combinations can inhibit both tumor growth in situ and metastasis to distant organs. Therefore, here, we developed chondroitin sulfate liposomes (CSLs) as a carrier for the co-delivery of retinoic acid (RA) and doxorubicin (DOX) and examined their efficiency in suppressing lung metastasis of breast cancer. CSLs were prepared using CS–deoxycholic acid conjugates and found to encapsulate both RA and DOX via hydrophobic and hydrophilic interactions. The resulting DOX+RA-CSLs were uniformly spherical and showed good serum stability and encapsulation efficiency of 98.7% ± 1.3% for RA and 90.8% ± 2.9% for DOX. Pharmacodynamic experiments in vitro and in vivo also revealed that DOX+RA-CSLs had better anticancer and anti-metastatic activity than CS-free liposomes, single drug-loaded liposomes, and free drug solutions at the same dose (2 mg/kg DOX or RA). Our results suggest that this liposomal delivery system can effectively suppress lung metastasis of breast cancer.

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“…Advances in biomedical engineering aiming at new solutions for personalized medicine have fostered new developments in fields ranging from interface electronics to biological systems [ 1 ]. In this context, nanofluidic devices have been increasingly used for control and manipulation of ionic species [ 2 ], energy conversion [ 3 , 4 , 5 , 6 ], ionic devices [ 7 , 8 , 9 ], biosensing [ 10 ], analysis and separation of biomolecules [ 11 , 12 ], and drug delivery [ 1 , 13 , 14 ]. Along with this, solid-state technological processes for very large-scale integration (VLSI) devices have enabled the fabrication of devices with high resolution and high-aspect-ratio features such as nanometric channel membranes [ 9 , 13 , 14 , 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…In this context, nanofluidic devices have been increasingly used for control and manipulation of ionic species [ 2 ], energy conversion [ 3 , 4 , 5 , 6 ], ionic devices [ 7 , 8 , 9 ], biosensing [ 10 ], analysis and separation of biomolecules [ 11 , 12 ], and drug delivery [ 1 , 13 , 14 ]. Along with this, solid-state technological processes for very large-scale integration (VLSI) devices have enabled the fabrication of devices with high resolution and high-aspect-ratio features such as nanometric channel membranes [ 9 , 13 , 14 , 15 , 16 , 17 ]. Among these systems, nanofluidic structures such as nanopores [ 18 , 19 , 20 ], nanoslits [ 21 , 22 , 23 ], and nanochannels [ 24 , 25 , 26 ] exhibit electrokinetic phenomena, such as ion current rectification, ion depletion, and ion gating, through the manipulation of their permselectivity.…”

Section: Introductionmentioning

confidence: 99%

“…Due to their molecular feature size, nanofluidic channels can offer precise control of and interaction with charged species, opening the possibility to develop new biomedical devices and therapeutic platforms for personalized medicine as well as chronotherapeutic regimens for chronic and dysfunctional diseases [ 27 , 28 , 29 ]. The active interaction of charged surfaces with aqueous media containing charged species such as ions [ 30 , 31 ], DNA [ 32 , 33 ], proteins [ 7 ], and nanoparticles [ 34 ] permits the implementation of analysis and processing for biosensors, molecular separation techniques, and drug-delivery systems [ 13 , 14 , 27 , 28 , 29 ]. This electrostatic interaction results in accumulation of ionic species at the surface of the nanofluidic channels, known as the electrical double layer (EDL).…”

Section: Introductionmentioning

confidence: 99%

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Silicon Carbide-Gated Nanofluidic Membrane for Active Control of Electrokinetic Ionic Transport

et al. 2021

Self Cite

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Manipulation of ions and molecules by external control at the nanoscale is highly relevant to biomedical applications. We report a biocompatible electrode-embedded nanofluidic channel membrane designed for electrofluidic applications such as ionic field-effect transistors for implantable drug-delivery systems. Our nanofluidic membrane includes a polysilicon electrode electrically isolated by amorphous silicon carbide (a-SiC). The nanochannel gating performance was experimentally investigated based on the current-voltage (I-V) characteristics, leakage current, and power consumption in potassium chloride (KCl) electrolyte. We observed significant modulation of ionic diffusive transport of both positively and negatively charged ions under physical confinement of nanochannels, with low power consumption. To study the physical mechanism associated with the gating performance, we performed electrochemical impedance spectroscopy. The results showed that the flat band voltage and density of states were significantly low. In light of its remarkable performance in terms of ionic modulation and low power consumption, this new biocompatible nanofluidic membrane could lead to a new class of silicon implantable nanofluidic systems for tunable drug delivery and personalized medicine.

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Potentiating Antitumor Efficacy Through Radiation and Sustained Intratumoral Delivery of Anti-CD40 and Anti-PDL1

Cited by 51 publications

References 60 publications

Improvements in Gold Nanorod Biocompatibility with Sodium Dodecyl Sulfate Stabilization

Improvements in Gold Nanorod Biocompatibility with Sodium Dodecyl Sulfate Stabilization

Chondroitin Sulfate-Modified Liposomes for Targeted Co-Delivery of Doxorubicin and Retinoic Acid to Suppress Breast Cancer Lung Metastasis

Silicon Carbide-Gated Nanofluidic Membrane for Active Control of Electrokinetic Ionic Transport

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