Potentiating effect of ecofriendly synthesis of copper oxide nanoparticles using brown alga: antimicrobial and anticancer activities

Abstract

This study reports the in vitro antimicrobial and anticancer activities of biologically synthesized copper nanoparticles. The antimicrobial activity of green synthesized copper oxide nanoparticles was assessed by well diffusion method. The anticancer activity of brown algae-mediated copper oxide nanoparticles was determined by MTT assay against the cell line (MCF-7). Maximum activity was observed with Pseudomonas aeruginosa and Aspergillus niger. Effective growth inhibition of cells was observed to be more than 93% in antibacterial activity. Thus, the results of the present study indicates that biologically synthesized copper nanoparticles can be used for several diseases, however, it necessitates clinical studies to ascertain their potential as antimicrobial and anticancer agents.

Unveiling the role of novel biogenic functionalized CuFe hybrid nanocomposites in boosting anticancer, antimicrobial and biosorption activities

“…This reflected the selective preference of these metal oxide NPs for cancer cells, which has been reported in a recent study 51 . Previous studies found that CuNPs synthesized by Bacillus cereus display a similar effect at IC 50 ≥ 20 μg/mL on MCF-7, Caco-2 and HepG2 cells 52 , while CuNPs produced by Sargassum polycystum brown seaweed at IC 50 = 61.25 μg/mL were effective on MCF-7 53 . On the other hand, Namvar et al 54 recorded the effect of IC 50 of 18.75 μg/mL and 23.83 μg/mL of iron oxide (IO) NPs synthesized by Sargassum muticum (seaweed) on MCF-7 and HepG2 cells, respectively.…”

Green biosynthesis, structural characterization and anticancer activity of copper oxide nanoparticles from the brown alga Cystoseira myrica

“…Compared to other biological sources, algal extracts are rich source of bioactive metabolites that act as reducing and stabilizing agents for the production of nanoparticles (Waris et al, 2021).They have acted as eco-friendly precursors for NPs synthesis with various applications. Few researches have been reported on the biosynthesis of copper oxide nanoparticles from algae and its anticancer activities (Abboud et al, 2014;Bhattacharya et al, 2019;Ramaswamy et al, 2016).…”

Green Synthesis of Copper Oxide Nanoparticles Using Protein Fractions from an Aqueous Extract of Brown Algae Macrocystis pyrifera

“…The interest in copper-based NPs is given to their optical, conducting, magnetic, catalytic, thermal, and antibiotic activity, owing to the enhanced physico-chemical properties due to their small surface to volume ratio when compared to its bulk material [9,10]. The use of raw aqueous algal extracts has been explored by a few authors as reductant and capping sources for the green synthesis of Cu-NPs [11][12][13][14][15]. In this context, copper oxide nanoparticles (CuO-NPs) have been successfully synthesized using a boiled aqueous extract from the brown algae Bifurcaria bifurcata and Cystoseira trinodis within a size range from 5 to 45 nm and 6 to 7.8 nm, respectively [11,14].…”

“…In this context, copper oxide nanoparticles (CuO-NPs) have been successfully synthesized using a boiled aqueous extract from the brown algae Bifurcaria bifurcata and Cystoseira trinodis within a size range from 5 to 45 nm and 6 to 7.8 nm, respectively [11,14]. In addition, an aqueous extract from brown seaweed (Sargassum polycystum) was used by Ramaswamy et al [13] to produce CuO-NPs. In a similar way, an autoclaved aqueous extract from the green microalgae Botryococcus braunii produced CuO-NPs in a size range between 10 and 70 nm [12].…”