Potentiating Effects on Pilocarpine-Induced Saliva Secretion, by Extracts and N-Containing Sugars Derived from Mulberry Leaves, in Streptozocin-Diabetic Mice.

Chen, Fujun; Nakashima, Noboru; Kimura, Ikuko; Kimura, Masayasu; Asano, Naoki; Koya, Sakuji

doi:10.1248/bpb.18.1676

Cited by 40 publications

(17 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides, Mulberry leaf is commonly used as silkworm diet. In previous reports, mulberry showed health-promoting effects, including antimicrobial, 6) anti-hyperglycemia, 7,8) antioxidant and antitumor effects. 9) Kuwanon X, a stilbene derivative, was firstly isolated from mulberry tree in 1985.…”

Section: )mentioning

confidence: 94%

Anti-HSV Activity of Kuwanon X from Mulberry Leaves with Genes Expression Inhibitory and HSV-1 Induced NF-κB Deactivated Properties

Shen

Zhang

et al. 2016

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Six stilbene derivatives isolated from Mulberry leaves including Kuwanon X, Mulberrofuran C, Mulberrofuran G, Moracin C, Moracin M 3′-O-b-glucopyranoside and Moracin M were found to have antiviral effects against herpes simplex virus type 1 and 2 (HSV-1 and HSV-2) at different potencies except for Mulberrofuran G. Kuwanon X exhibited the greatest activity against HSV-1 15577 and clinical strains and HSV-2 strain 333 with IC 50 values of 2.2, 1.5 and 2.5 µg/mL, respectively. Further study revealed that Kuwanon X did not inactivate cell-free HSV-1 particles, but inhibited cellular adsorption and penetration of HSV-1 viral particles. Following viral penetration, Kuwanon X reduced the expression of HSV-1 IE and L genes, and decreased the synthesis of HSV-1 DNA. Furthermore, it was demonstrated that Kuwanon X inhibited the HSV-1-induced nuclear factor (NF)-κB activation through blocking the nuclear translocation and DNA binding of NF-κB. These results suggest that Kuwanon X exerts anti-HSV activity through multiple modes and could be a potential candidate for the therapy of HSV infection.Key words anti-herpes simplex virus (HSV) activity; Kuwanon X; penetration; gene expression; nuclear factor (NF)-κB; Mulberry Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are prevalent pathogens worldwide. HSV-1 is the main cause of orofacial herpes, cephalitis, corneal blindness, and several disorders of the peripheral nervous system; HSV-2 is usually associated with recurrent genital herpes, meningoencephalitis in neonates and meningitis in adults. Both HSV-1 and HSV-2 can cause latent infections in the neurons system, and then cause lesions at or near the point of entry into the body when they are reactivated.1,2) Recently, it was reported that HSV infections can increase the transmission of human immunodeficiency virus type 1 (HIV-1) and human T-cell leukemia virus type 1 (HTLV-1).3) During the productive infection, a successful HSV replication cycle is dependent on the completion of several steps, including α (immediate-early or IE), β (early or E), γ (late or L) genes and unpaired DNA replication based on sequential expression. The IE genes, such as UL54, encode transacting regulators of gene expression. The E genes, including UL52, are involved in viral DNA synthesis and nucleotide metabolism. The L genes, mainly encode structural proteins, e.g. ICP5 encoding the main capsid protein VP5. 4)The standard therapy for HSV infections are nucleoside analogues, such as acyclovir (ACV) and penciclovir. However, the emergence of HSV strains resistant to ACV remains an important clinical concern in immunocompromised individuals.5) Therefore, it is necessary to develop new antiherpetic agents with mechanisms of action different from that of nucleoside analogues.Mulberry (Morusalba L.) is widely cultivated in several Asian countries. Its leaves, fruits, twigs and root barks have long been used in Chinese medicine to reduce fever, maintain liver health, improve eyesight and lower blood pressure. Besides, Mulberry leaf is commonly...

show abstract

Section: )mentioning

confidence: 94%

Anti-HSV Activity of Kuwanon X from Mulberry Leaves with Genes Expression Inhibitory and HSV-1 Induced NF-κB Deactivated Properties

Shen

Zhang

et al. 2016

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

show abstract

“…1) Compounds that stimulate insulin secretion: non-saponin fraction of ginseng root (Panax spp., Araliaceae), 1,2) fagomine, a N-containing sugar derived from mulberry leaves ( Morus spp., Moraceae.) [3][4][5] and gymnemic acid IV ( Fig. 1(A)) derived from Gymnema sylvestre (Asclepiadaceae) leaves, 6) 2) Compounds that inhibit intestinal glucose absorption (glycosidase inhibition): gymnemic acid IV, 3) Compounds that increase glucose uptake in striated muscles: mulberry leaf extract, 7) 4) Compounds that inhibit the sweet taste (antisweet eŠect): gymnemic acid IV, 8) 5) Compounds with other mechanisms not associated with insulin release: pseudoproto-timosaponin-AIII derived from rhizomes of Anemarrhena asphodeloides (Liliaceae), 9) and green tea (Camellia sinensis, Theaceae), 10) and with unidentiˆed mechanisms: isofumulones from ‰ower cone with lupulin of hops (Humulus lupulus L., Moraceae).…”

Section: Multidirectional Antihyperglycemic Actions Of Gymnemic Acid IVmentioning

confidence: 99%

Medical Benefits of Using Natural Compounds and Their Derivatives Having Multiple Pharmacological Actions

Kimura

2006

YAKUGAKU ZASSHI

Self Cite

View full text Add to dashboard Cite

The multiple pharmacological actions of a unique compound are a prerequisite for classifying drugs as highly e‹cacious, because the multiple pharmacological actions oŠer the possibility of treating various symptoms of chronic diseases as described below. 1) Sustained hyperglycemia induces macrovascular and microvascular complications in type 2 diabetes mellitus. Antihyperglycemic medication and the control of postprandial hyperglycemia are essentially important for normalizing plasma glucose level. Gymnemic acid IV isolated from Gymnema sylvestre (Asclepiadaceae) leaves has antisweet, antihyperglycemic, glucose uptake inhibitory, and gut glycosidase inhibitory eŠects. Most of these pharmacological eŠects may synergistically contribute to alleviating type 2 diabetes-related symptoms. 2) Diabetic skeletal and vascular smooth muscles are hypersensitive to chemical transmitters, cytokines and autacoids. The sensitivity of neuromuscular synapses is enhanced in diabetes, which seems to be closely associated with neuropathy as one of the diabetic complications. b-Eudesmol found in Atractylodes lancea rhizome has a desensitizing channel blocking action to nicotinic acetylcholine receptors, anti-angiogenic action in vascular endothelium, and neuronal diŠerentiation actions. These multiple pharmacological actions are favorable for treating angiogenic diseases possibly including the complications of diabetes, namely, retinopathy and nephropathy, and cancer. 3) Nipradilol is clinically utilized as a topical antiglaucoma drug. The ocular hypotensive eŠects of this compound are brought about by its a 1 -and b-adrenergic receptor blocking actions, and nitric oxide (NO) releasing action. NO directly activates cyclooxygenases. All these pharmacologic eŠects are beneˆcial for treating glaucoma. The selectivity and speciˆcity of drug action are required for treating acute diseases, infections or for acting as useful reagents. The pleiotropic actions of natural compounds and their derivatives serve as important clues for developing new drugs for various chronic diseases.

show abstract

“…Plants of the Morus genus are known to be rich in flavonoids and have been shown to exhibit anti-HIV, anti-oxidative, antihypotensive and cytotoxic activities (Nomura et al, 1980;Nomura et al, 1978;Luo et al, 1995;Hosseinzadeh et al, 1999;Kim et al, 1999;Doi et al, 2001). Morus Folium has been traditionally used in Korea, China and Japan for various medicinal purposes, such as clear the lung and moisten dryness, clear the liver, promote hair, eliminate abiding blood, stop thirst, soothe and disperse wind-heat, aching and numbness of joints, moisten dryness (Chen et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Molecular Authentication of Morus Folium Using Mitochondrial nad7 Intron 2 Region

Jin¹,

Kim²,

Kim³

et al. 2013

Korean Journal of Plant Resources

View full text Add to dashboard Cite

-Morus Folium (Sang-yeop in Korean) is one of the most important Oriental medicinal plants. In Korea, both M. alba and M. cathayana are regarded as the botanical sources for Morus Folium. In order to discriminate M. alba and M. cathayana from their adulterant, M. tricuspidata, mitochondrial NADH dehydrogenase subunit 7 (nad7) intron 2 region was targeted for molecular analysis with universal primers. DNA polymorphisms, including SNP sites, insertions, and deletions, were detected among these three species sequencing data. Based on these DNA polymorphisms, specific primers were designed for the three species respectively. Multiplex PCR was conducted for molecular authentication of M. alba, M. cathayana, and M. tricuspidata with specific primers. The present results indicate that it is possible to identify Morus Folium from its adulterant using mitochondrial nad7 intron 2 region. The established multiplex-PCR system was proved to be effective for identification of Morus Folium. The results indicate that mitochondrial introns can be used for inter-specific polymorphic study, and the described method can be applied for molecular identification of medicinal materials.

show abstract

Potentiating Effects on Pilocarpine-Induced Saliva Secretion, by Extracts and N-Containing Sugars Derived from Mulberry Leaves, in Streptozocin-Diabetic Mice.

Cited by 40 publications

References 0 publications

Anti-HSV Activity of Kuwanon X from Mulberry Leaves with Genes Expression Inhibitory and HSV-1 Induced NF-κB Deactivated Properties

Anti-HSV Activity of Kuwanon X from Mulberry Leaves with Genes Expression Inhibitory and HSV-1 Induced NF-κB Deactivated Properties

Medical Benefits of Using Natural Compounds and Their Derivatives Having Multiple Pharmacological Actions

Molecular Authentication of Morus Folium Using Mitochondrial nad7 Intron 2 Region

Contact Info

Product

Resources

About