Potentiation by amphotericin B of the cytotoxicity of anticancer agents against MOPC-315 plasmacytoma and lewis lung carcinoma

Valeriote, Frederick A.; Dieckman, Julia; Flentje, D.; Flentje, M.; Medoff, Gerald

doi:10.1007/bf00257129

Cited by 8 publications

(4 citation statements)

References 3 publications

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“…Furthermore they may also act in synergy with other drugs, such as anticancer or antiviral compounds [62,63]. The pentaene faeriefungin is a broad-spectrum antibiotic active against fungi, bacteria, nematodes and mosquito larvae [64].…”

Section: Mode Of Actionmentioning

confidence: 99%

Polyene Macrolide Antibiotic Biosynthesis

Aparicio¹,

Mendes²,

Antón³

et al. 2004

CMC

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Polyenes constitute a large class of natural metabolites produced by giant multifunctional enzymes in a process resembling fatty acid biosynthesis. Like fatty acids, polyene macrolides and other polyketides are assembled by decarboxylative condensations of simple carboxylic acids. But while fatty acid intermediates are fully reduced, polyene macrolide intermediates suffer the suppression of reduction or dehydration reactions at given biosynthetic steps. In the last years, much progress has been made in our understanding of the linear and modular organization of the gene clusters, and the enzymes encoded by them, responsible for the biosynthesis of these macrocyclic metabolites. This know-how about the rules that govern polyene chain growth has provided the basis for the first rational manipulations of these fascinating systems for the production of engineered derivatives and promises a new era of novel polyene development, which will hopefully yield new molecules with improved pharmacological properties.

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Section: Mode Of Actionmentioning

confidence: 99%

Polyene Macrolide Antibiotic Biosynthesis

Aparicio¹,

Mendes²,

Antón³

et al. 2004

CMC

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“…Significance was determined using one-way ANOVA followed by Tukey's multiple comparisons test, with p < 0.05 (*), p < 0.01 (**), p < 0.001 (***), p < 0.0001 (****). A version of the Valeriote and Lin model was applied for calculation of expected additive combination effects of spheroids and has been described previously [ 32 ]. In short, effects of the combination of sorafenib and 131 I-AbN44v6 were analyzed, using a version of the ‘additive model’.…”

Section: Methodsmentioning

confidence: 99%

Utilizing CD44v6 and V600EBRAF-mutation for in vitro targeted combination therapy of thyroid carcinomas

Mortensen,

Imgenberg-Kreuz,

Spiegelberg

et al. 2023

Heliyon

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“…If the actually observed SF of the combination is lower, the two treatments interact supra-additively. This basic equation was previously employed to assess potential supra-additive interactions of cytotoxic treatments 29,30 and was recently applied to combinations of TTFields and RT 19,21 or chemotherapy. 23 Similar to, 23 we descriptively compared the real SF curve to the expected additive effect curve to classify treatment interactions.…”

Section: Combination Experimentsmentioning

confidence: 99%

Tumor treating fields as novel combination partner in the multimodal treatment of head and neck cancer

et al. 2023

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Background: We aimed to demonstrate the effects of tumor treating fields (TTFields) in head and neck squamous cell carcinoma (HNSCC) cells when combined with radiotherapy (RT) and chemotherapy.Methods: Two human HNSCC cell lines (Cal27, FaDu) received five different treatments: TTFields, RT +/À TTFields and RT + simultaneous cisplatin +/À TTFields. Effects were quantified using clonogenic assays and flow cytometric analyses of DAPI, caspase-3 activation and γH2AX foci. Results: Treatment with RT + TTFields decreased the clonogenic survival as strong as treatment with RT + simultaneous cisplatin. The triple combination of RT + simultaneous cisplatin + TTFields even further decreased the clonogenic survival. Accordingly, combination of TTFields with RT or RT + simultaneous cisplatin increased cellular apoptosis and DNA double-strand breaks. Conclusion: TTFields therapy seems a promising combination partner in the multimodal treatment of locally advanced HNSCC. It could be used to intensify chemoradiotherapy or as alternative to chemotherapy. K E Y W O R D S chemoradiotherapy, head and neck cancer, radiotherapy, squamous cell carcinoma of head and neck, tumor treating fields

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Potentiation by amphotericin B of the cytotoxicity of anticancer agents against MOPC-315 plasmacytoma and lewis lung carcinoma

Cited by 8 publications

References 3 publications

Polyene Macrolide Antibiotic Biosynthesis

Polyene Macrolide Antibiotic Biosynthesis

Utilizing CD44v6 and V600EBRAF-mutation for in vitro targeted combination therapy of thyroid carcinomas

Tumor treating fields as novel combination partner in the multimodal treatment of head and neck cancer

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