1997
DOI: 10.1038/sj.onc.1201421
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Potentiation of apoptosis by low dose stress stimuli in cells expressing activated MEK kinase 1

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Cited by 66 publications
(48 citation statements)
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“…We also identified a high frequency of mutation in Map2k4 and Mapk8. These genes are important components in the activation of apoptosis in response to stress (62), which might explain why these genes are inactivated in SB-Pten tumors. Finally, we also identified a high frequency of transposon insertions in chromatin-remodeling and -modifying enzymes.…”
Section: Discussionmentioning
confidence: 99%
“…We also identified a high frequency of mutation in Map2k4 and Mapk8. These genes are important components in the activation of apoptosis in response to stress (62), which might explain why these genes are inactivated in SB-Pten tumors. Finally, we also identified a high frequency of transposon insertions in chromatin-remodeling and -modifying enzymes.…”
Section: Discussionmentioning
confidence: 99%
“…Expression of an activated form of Mekk-1 results in the potentiation of apoptosis to a number of factors including TNF. 128 FAS-induced activation of the Jnk pathway is reported to require caspase activation, 129 however, in the IL-3-dependent cell line BAF-3, over-expression of a Jnk specific phosphatase (M3/6) did not effect FAS-mediated apoptosis. 130 These data support the idea that FAS-induced apoptosis may lead to the induction of Jnk activation, but this activation is not required for FAS-induced apoptosis of hematopoietic cells.…”
Section: The Stress-activated Protein Kinasesmentioning
confidence: 99%
“…Apoptosis triggered by UV, ␄-irradiation, and cytotoxic drugs is correlated with activation of JNK, and the cell death is prevented by inhibition of JNK activation (1)(2)(3)(4)(5). The pivotal role of JNK is further illustrated by JNK activation induced by active mitogen-activated protein kinase kinase kinase 1 (MEKK1) (2,6), active Cdc42 (7), and apoptosis signal-regulating kinase 1 (8) that either initiates the apoptotic process or potentiates cell death triggered by low dose stress stimuli (9). JNK activation is implicated in growth factor deprivation-induced cell death (10 -12), in class I major histocompatibility complex ligation-triggered apoptosis (13), or possibly in anoikis (14).…”
Section: Jnkmentioning
confidence: 99%