Potentiation of Autoimmune Response in Rats Infected With Toxoplasma Gondii. Effect of the Infection Route

Romero-Piffiguer, Marta; Ferro, Maria Elena; Riera, Clelia M.

doi:10.7883/yoken1952.40.175

Cited by 8 publications

(2 citation statements)

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“…It may also cause abortion in sheep, pigs, and rabbits infected during pregnancy 7 . Rats infected with T. gonddi develop good humoral and cell immune response within a short length of time 13 . In relation to the clinical evolution and the placental transmission, toxoplasmosis in rats and humans is alike; therefore, infection in rats may be used as a model for human toxoplasmosis 14 .…”

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Alterations of the myenteric plexus of the ileum and the descending colon caused by Toxoplasma gondii (genotype III)

Sugauara

Sant’Ana

Almeida

et al. 2008

Arq. Neuro-Psiquiatr.

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-Alterations caused by a genotype III strain of Toxoplasma gondii were assessed with respect to the number and the morphometry of the myenteric neurons in the terminal ileum and the descending colon. Eighteen rats were divided into four groups: Acute Control Group (ACG, n=4); Acute Experimental Group (AEG, n=4); Chronic Control Group (CCG, n=5) and Chronic Experimental Group (CEG, n=5). NaCl solution was administered through gavage to the animals in the ACG and CCG. Toxoplasma gondii tachyzoites (10 4 ) from a genotype III strain were orally administered to the AEG and CEG. Acute Groups were died after 24 hours, and the Chronic Groups after 30 days. Neuronal loss was not observed in both organs. The neurons atrophied in the terminal ileum as the opposite occurred with the neurons at the descending colon during the chronic phase of infection. In the terminal ileum, the neurons atrophied during the chronic phase of the infection as no alteration was found during the acute phase. For the descending colon, the neurons became hypertrophic during the chronic infection in opposition to the atrophy found during the acute phase.KEY WORDS: enteric nervous system, toxoplasmosis, morphology. Alterações do plexo mientérico do íleo e cólon descendente causadas por Toxoplasma gondii (genótipo III)Resumo -Objetivou-se avaliar as alterações causadas por uma cepa genótipo III de Toxoplasma gondii, sobre o número e a morfometria de neurônios mientéricos, do íleo terminal e do cólon descendente. Dividiuse dezoitos ratos em quatro grupos: controle agudo (GCA, n=4), experimental agudo (GEA, n=4), controle crônico (GCC, n=5) e experimental crônico (GEC, n=5). Os animais do GCA e GCC receberam solução de NaCl por gavagem, e os animais do GEA e GEC 10 4 taquizoítos de uma cepa genótipo III de T. gondii por via oral. Os grupos agudos após 24 horas foram mortos e os crônicos após 30 dias. Observou-se que não houve perda neuronal em ambos os órgãos. No íleo terminal, os neurônios atrofiaram-se na fase crônica da infecção, enquanto nenhuma alteração ocorreu na fase aguda. Já no cólon descendente, os neurônios tornaram-se hipertróficos na fase crônica da infecção, em oposição à atrofia observada na fase aguda. PALAVRAS-CHAVE: sistema nervoso entérico, toxoplasmose, morfologia.

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Alterations of the myenteric plexus of the ileum and the descending colon caused by Toxoplasma gondii (genotype III)

Sugauara

Sant’Ana

Almeida

et al. 2008

Arq. Neuro-Psiquiatr.

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“…In previous works we demonstrated that T. gondii infection of Wistar rats in the thymus proximity was able to enhance the autoimmune response to autoantigens of male accessory glands and to impair thymic cellular populations [19][20][21]. This parasite is an obligate intracellular pathogen, having the gastrointestinal mucosa as its main means of entry [22].…”

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confidence: 99%