Potentiation of bradykinin-induced inositol phosphates production by cyclic AMP elevating agents and endothelin-1 in cultured astrocytes

Chen, Ching-C.; Chang, Jason; Chen, Wei C.

doi:10.1002/(sici)1098-1136(199603)16:3<210::aid-glia3>3.0.co;2-5

Cited by 13 publications

(3 citation statements)

References 32 publications

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“…Astrocytes respond to extracellularly applied ATP, which causes release of Ca 2+ from an intracellular Ins(1,4,5)P 3 -sensitive pools. Increases in PPI hydrolysis and [Ca 2+ ] i were elicited by intracellular application of GTP(S) and AlFx in astrocytes from the dorsal spinal cord [77,163]. AlFx also stimulated the tyrosine phosphorylation of a 42 kDa protein (p42) and activation of p42 MAP kinase in primary cultures of mouse embryo astrocytes [164].…”

Section: Microglial Cellsmentioning

confidence: 98%

Fluoride Interactions: From Molecules to Disease

Strunecká¹,

Patočka²,

Blaylock³

et al. 2007

CST

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Fluoride has long been known to influence the activity of various enzymes in vitro. Later it has been demonstrated that many effects primarily attributed to fluoride are caused by synergistic action of fluoride plus aluminum. Aluminofluoride complexes have been widely used as analogues of phosphate groups to study phosphoryl transfer reactions and heterotrimeric G proteins involvement. A number of reports on their use have appeared, with far-reaching consequences for our understanding of fundamental biological processes. Fluoride plus aluminum send false messages, which are amplified by processes of signal transduction. Many investigations of the longterm administration of fluoride to laboratory animals have demonstrated that fluoride and aluminofluoride complexes can elicit impairment of homeostasis, growth, development, cognition, and behavior. Ameliorative effects of calcium, vitamins C, D, and E have been reported. Numerous epidemiological, ecological, and clinical studies have shown the effects of fluoride on humans. Millions of people live in endemic fluorosis areas. A review of fluoride interactions from molecules to disease is necessary for a sound scientific assessment of health risks, which may be linked to the chronic intake of small doses of fluoride and aluminum from environmental and artificial sources.

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Section: Microglial Cellsmentioning

confidence: 98%

Fluoride Interactions: From Molecules to Disease

Strunecká¹,

Patočka²,

Blaylock³

et al. 2007

CST

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“…Indeed, it has been found that astrocyte differentiation is accompanied by elevation of intracellular cAMP (Chen et al, 1996). The exact mechanism of these events remains to be elucidated.…”

Section: Resultsmentioning

confidence: 99%

Cyclic Adenosine Monophosphate (cAMP)-Induced Histone Hyperacetylation Contributes to its Antiproliferative and Differentiation-Inducing Activities

Yoo

Lee

Kim

et al. 2012

Zeitschrift Für Naturforschung C

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Histone acetylation is linked to the control of chromatin remodeling, which is involved in cell growth, proliferation, and differentiation. It is not fully understood whether cyclic adenosine monophosphate (cAMP), a representative differentiation-inducing molecule, is able to modulate histone acetylation as part of its anticancer activity. In the present study, we aimed to address this issue using cell-permeable cAMP, i.e. dibutyryl cAMP (dbcAMP) and C6 glioma cells. As reported previously, under the conditions of our studies, treatment with dbcAMP clearly arrested C6 cell proliferation and altered their morphology. Its antiproliferative and differentiation-inducing activity in C6 glioma cells involved upregulation of p21 WAF/CIP , p27 kip1 , glial fi brillary acidic protein (GFAP), and Cx43, as well as downregulation of vimentin. Furthermore, dbcAMP modulated the phosphorylation of ERK and Akt in a time-dependent manner and altered the colocalization pattern of phospho-Src and the actin cytoskeleton. Interestingly, dbcAMP upregulated the enzyme activity of histone acetyltransferase (HAT) and, in parallel, enhanced cellular acetyllysine levels. Finally, the hyperacetylation-inducing compound, sodium butyrate (NaB), a histone deacetylase (HDAC) inhibitor, displayed similar anticancer activity to dbcAMP. Therefore, our data suggest that antiproliferative and differentiation-inducing activities of dbcAMP may be generated by its enhanced hyperacetylation function.

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“…The PAG‐mediated effect could include neurons with perikarya located in the amygdala, because injection of the μ ‐opioid agonist, DAMGO, into the basolateral part of the amygdala that expresses B2 receptors in high density inhibits the tail‐flick reflex through the PAG ( Helmstetter et al ., 1998 ; Chen et al ., 2000 ), and easily accessible for drugs from the lateral ventricle. Alternatively, BK and its analogues could activate neurons indirectly, through inducing the release of substances from B2 receptor‐expressing ependyma cells, oligodendrocytes or astrocytes ( Raidoo and Bhoola, 1998 ; Chen et al ., 1996 ).…”

mentioning

confidence: 99%

Taking the sting out of pain

Nagy

Paule

White

et al. 2007

British J Pharmacology

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While the role of the brain kallikrein-kinin system in the development of various pathological processes, such as oedema formation following brain injury or induction of central hypertonia has generated major interest, the possible role of this system in nociceptive processing has received little attention. In their present paper, Mortari et al. (2007) show that bradykinin B2 receptor activation in the brain by the bradykinin analogue, Thr(6)-bradykinin, isolated from the venom of the social wasp, Polybia occidentalis potently reduces acute, noxious heat-evoked reflex responses in naive rats. The unknown underlying mechanism of this powerful antinociceptive effect reminds us that the supraspinal antinociceptive system is still a "black box" in many aspects and awaits thorough investigation.

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Potentiation of bradykinin-induced inositol phosphates production by cyclic AMP elevating agents and endothelin-1 in cultured astrocytes

Cited by 13 publications

References 32 publications

Fluoride Interactions: From Molecules to Disease

Fluoride Interactions: From Molecules to Disease

Cyclic Adenosine Monophosphate (cAMP)-Induced Histone Hyperacetylation Contributes to its Antiproliferative and Differentiation-Inducing Activities

Taking the sting out of pain

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