Potentiation of human immunoglobulin E synthesis by plasma immunoglobulin E binding factors from patients with the hyperimmunoglobulin E syndrome.

Leung, Donald Y.M.; Frankel, R; Wood, Nancy; Geha, Raif S.

doi:10.1172/jci112395

Cited by 18 publications

(4 citation statements)

References 16 publications

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“…It has been suggested that IgE-binding factors (sCD23) play an essential role with regard to the regulation for IgE. Furthermore, it was de scribed that sera of patients with hyper IgE syndrome and atopic dermatitis contain IgE-BF (sCD23) with a molecular weight of 60 kD [2,22], whereas in normal sera the IgE-BFs with 45 and 25 kD were detected. Lymphocytes of atopic patients carry a higher percent age of cell-bound CD23 as compared with peripheral Serum sCD23, % binding blood lymphocytes of normal donors.…”

Section: Discussionmentioning

confidence: 99%

Correlation of sCD23 Release and Immunoglobulin (E, A, G, M) Synthesis by Peripheral Blood Lymphocytes of Atopic Patients

Bujanowski-Weber¹,

Knöller²,

Pfeil³

et al. 1990

Int Arch Allergy Immunol

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Peripheral blood lymphocytes of atopic patients were analyzed with regard to spontaneous as well as mitogen-induced CD23 expression, sCD23 release as well as Ig (M, G, A, E) synthesis in vitro. The data were correlated with the results for phenotypically defined peripheral cells (T cells, B cells, monocytes), sCD23 release and amounts of Ig (M, G, A, E). A positive correlation was obtained for serum sCD23 and serum IgE of patients with high and intermediate IgE levels, of sCD23 with the percentage of B cells and sCD23 with serum IgA levels. No correlation was obtained for the mitogen (SAC, PWM) induced amounts of Ig (E, A, M, G) synthesis and, furthermore, sCD23 levels determined in cell culture did not correlate with serum IgE levels. Our data support the role of sCD23 in atopic diseases and in isotype regulation.

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Section: Discussionmentioning

confidence: 99%

Correlation of sCD23 Release and Immunoglobulin (E, A, G, M) Synthesis by Peripheral Blood Lymphocytes of Atopic Patients

Bujanowski-Weber¹,

Knöller²,

Pfeil³

et al. 1990

Int Arch Allergy Immunol

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“…This finding was confirmed by de la Parva et al [29] who, in addition, found stimulation of IgE synthesis in normal lymphocytes by atopic serum and an inhibition of IgE synthesis by nonatopic serum. Recently, affinity-purified IgE binding factors from the plasma of patients with hyper-IgE syndrome have been found to enhance IgE synthesis by B cells from patients with allergic rhinitis but not from normal nonatopic donors [30]. The potential removal of circulating IgE synthesis-enhancing factors provides an additional rationale for use of plasmapheresis in treatment of hyper-IgE syndrome.…”

Section: Acknowledgmentsmentioning

confidence: 99%

Remission of hyper‐lgE syndrome treated with plasmapheresis and cytotoxic immunosuppression

Dau

1988

J of Clinical Apheresis

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A patient with a hyper-IgE syndrome was treated with 60 plasmaphereses over a period of 2 years in conjunction with cytotoxic immunosuppressive drug therapy. During this time her severe dermatitis of 8 years' duration became almost completely inactive, and her circulating IgE level was reduced by 73%. An elevated pretreatment ratio of CD4+/CD8+ T lymphocytes fell to subnormal. The beneficial results of treatment may be attributed to the reduction of lymphocyte populations responsible for IgE production by the combined action of plasmapheresis and of cytotoxic drugs as well as the direct effect of removal of circulating IgE and possibly IgE-potentiating factors.

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“…Fur thermore, it was shown that sera of patients with chronic lymphatic leukemia contained high amounts of sCD23 [7], Furthermore, a significant correlation of sCD23 and IgE was observed when sera of patients with atopic dermatitis were analyzed which contained high (> 1,000 ng/ml) values of IgE. In addition, the sCD23 serum values correlated sig nificantly with the IgA amounts detected within the sera suggesting that IgE synthesis and IgA production have common regulatory parameters [8], The analysis of the molecular weight (MW) pattern of IgE-BF revealed that the pattern within the sera of patients with hyper-IgE syn drome [9] and patients with atopic dermatitis [10] is differ ent from the pattern observed in normal sera. The sera of these patients contained an additional 60 kD IgE-binding component.…”

Section: Introductionmentioning

confidence: 99%

Analysis of IgE-Binding Factors (sCD23) within Newborn Sera

Bujanowski-Weber

Knöller²,

Wahn³

et al. 1992

Int Arch Allergy Immunol

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factors are discussed as potential diagnostic parameters of atopic disorders. The amounts of sCD23 in sera from newborn children (n = 4,329) were determined by radioimmunoassay with monoclonal antibodies specific for CD23. The sCD23 levels ranged between 0 and 81.5 ng/ml of CD23-specific mAb. Furthermore, the sera of newborns with more than 5 ng/ml (n = 45) were analyzed by SDS/PAGE and subsequent autoradiography using ¹²⁵I-labeled IgE (PS). These experiments indicate that newborn sera with normal sCD23 amounts contain an IgE-binding activity with a molecular weight of 25 kD; this component was not observed within sera containing elevated amounts ( > 5 ng/ml). In addition, a 60-kD IgE-binding component was detected within most of all newborn sera (76.4%). The data show that the IgE-binding pattern of newborn children and the pattern of adult donors are different. Our data suggest that the measurement of quantitative sCD23 amounts combined with the analysis of the molecular weight pattern of the IgE-binding factors might be a helpful diagnostic parameter with regard to IgE-associated diseases.

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Potentiation of human immunoglobulin E synthesis by plasma immunoglobulin E binding factors from patients with the hyperimmunoglobulin E syndrome.

Cited by 18 publications

References 16 publications

Correlation of sCD23 Release and Immunoglobulin (E, A, G, M) Synthesis by Peripheral Blood Lymphocytes of Atopic Patients

Correlation of sCD23 Release and Immunoglobulin (E, A, G, M) Synthesis by Peripheral Blood Lymphocytes of Atopic Patients

Remission of hyper‐lgE syndrome treated with plasmapheresis and cytotoxic immunosuppression

Analysis of IgE-Binding Factors (sCD23) within Newborn Sera

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