Potentiation of hydrogen peroxide, nitric oxide, and cytokine production in RAW 264.7 macrophage cells exposed to human and commercial isolates of Bifidobacterium

Park, S

doi:10.1016/s0168-1605(98)00197-4

Cited by 75 publications

(45 citation statements)

References 44 publications

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“…Aside from interferons and pro-interferon factors, LAB are also capable of inducing expression of other regulatory cytokines, such as IL-1, IL-6, IL-8 and tumor necrosis factor-α (TNFα) [57, 58, 59], but, as previously outlined, excessive tissue responses are ordinarily controlled by the co-induction of auto-regulatory anti-inflammatory signals, such as IL-10 and TGFβ. Recent research has indicated that both mononuclear leucocytes and immunocompetent gut epithelial cells are capable of transducing these multiple cytokine signals from contacting LAB [4, 5, 6], yet research to identify the factors involved in this signalling has made only limited progress.…”

Section: Signalling Mechanisms Of Anti-allergy Immunoregulatory Labmentioning

confidence: 99%

Can Immunoregulatory Lactic Acid Bacteria Be Used as Dietary Supplements to Limit Allergies?

Cross

Gill²

2001

Int Arch Allergy Immunol

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Studies in gnotobiotic animals have suggested that the intestinal bacterial flora may play an important role in priming the immune system during ontogeny to limit dysfunctional responses, including allergy. Prospective clinical studies have identified a higher incidence of allergy expression in early childhood among children who have low enteric populations of lactic acid bacteria (LAB), such as lactobacilli and bifidobacteria, further supporting a role for gut-colonizing bacteria in regulating immunological atopy. There is some evidence to suggest that supplementing the human diet with probiotic LAB might combat both allergy development and expression of atopy in allergy sufferers; however, definitive information, in the form of controlled intervention trials, remains scant. Recent immunological evidence has indicated that certain strains of LAB can stimulate the production of type I and II interferons and pro-interferon monokines (IL-12 and IL-18), following contact with the immune system; therefore, probiotic forms of immunoregulatory LAB could be used as dietary supplements to modify the gut microflora and provide pro-T helper cell 1 (Th1) STAT-activating signals sufficient to deviate the immune phenotype and correct the Th2-type bias which promotes allergy. This review outlines the clinical and laboratory evidence of a role for LAB in combating allergies, and attempts to explain this phenomenon in terms of our current understanding of immunoregulatory signals produced by gut-colonizing microbes.

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Section: Signalling Mechanisms Of Anti-allergy Immunoregulatory Labmentioning

confidence: 99%

Can Immunoregulatory Lactic Acid Bacteria Be Used as Dietary Supplements to Limit Allergies?

Cross

Gill²

2001

Int Arch Allergy Immunol

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“…NO and various cytokines, such as IL-6 and TNF-a, in macrophage cell lines (Kim et al, 2007a(Kim et al, , 2007bMarcinkiewicz et al, 2007;Park et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…NO is an important macrophage mediator by acting as a reactive oxygen and nitrogen intermediate during oxygen-dependent phagocytosis (Park et al, 1999). Generation of oxidative stress and NO are closely related in the inflammatory responses in cells.…”

Section: Discussionmentioning

confidence: 99%

Immunomodulatory effects of deadLactobacilluson murine splenocytes and macrophages

Chiang

Liu

Tseng

et al. 2012

Food and Agricultural Immunology

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To elucidate the immunomodulation effects of dead lactobacilli, whole cells and gastrointestinal enzymatic hydrolysates of supernatants and precipitates from Lactobacillus paracasei subsp. paracasei NTU 101 and L. plantarum NTU 102 on RAW264.7 macrophages and splenocytes were investigated. Increased NO, COX-2 expression, IL-10 and IL-12 were observed in high-dose precipitates and whole cells of both strains after 24-h stimulation. All of the hydrolysates and whole cells from both strains induced lower pro-inflammatory cytokines (IL-1b and IL-6) than LPS. The supernatants activated cell division to the S phase or promoted advance to the G2/M phase. Regardless of the Lactobacillus strains, higher levels of TNF-a, IL-6, IL-10 and IL-12 in splenocytes were induced by the precipitates. Supernatant of NTU 101 increased the amounts of IFN-g than precipitate in splenocytes. It shows that hydrolysates of NTU 101 induce the proliferations of macrophage and splenocyte and the release of IL-10 and IL-12 cytokines to modulate the innate and adaptive immune systems and inflammatory response.

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“…the production of NO and TNF-α by macrophages mediates killing and growth inhibition of tumor cells, bacteria and fungi (19). tumor necrosis factor alpha (TNF-α) is representative cytokine released from macrophages by lipopolysaccharide (LPS) or phorbol-2-myristate-13-acetate (PMA), and an important mediator of allergy responses and inflammation (17). Therefore, cytokine production is a good measure of macrophage activation, and its measurement can help understand how lAB strains affect immune function at the cellular level (20).…”

Section: Immunological Activitymentioning

confidence: 99%

Comparison of Dual Coated (Duolac™) and Uncoated Lactic Acid Bacteria from Potential Probiotics

Kyeong¹,

Chung²,

Kim³

et al. 2011

Biotechnology & Biotechnological Equipment

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Potentiation of hydrogen peroxide, nitric oxide, and cytokine production in RAW 264.7 macrophage cells exposed to human and commercial isolates of Bifidobacterium

Cited by 75 publications

References 44 publications

Can Immunoregulatory Lactic Acid Bacteria Be Used as Dietary Supplements to Limit Allergies?

Can Immunoregulatory Lactic Acid Bacteria Be Used as Dietary Supplements to Limit Allergies?

Immunomodulatory effects of deadLactobacilluson murine splenocytes and macrophages

Comparison of Dual Coated (Duolac™) and Uncoated Lactic Acid Bacteria from Potential Probiotics

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