Potentiation of IL-19 expression in airway epithelia by IL-17A and IL-4/IL-13: Important implications in asthma

Huang, Fei; Wachi, Shinichiro; Thai, Phung N.; Loukoianov, Artem; Tan, Kin Hup; Forteza, Rosanna; Wu, Reen

doi:10.1016/j.jaci.2008.04.016

Cited by 97 publications

(92 citation statements)

References 40 publications

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“…In asthmatics, IL19 serum levels are increased, but no human data on levels in bronchoalveolar lavages have been published (35). In mice and humans, IL19 overexpression enhanced allergic airway inflammation by the induction of Th2 cytokines (35,36). However, nonallergic mechanisms by which IL19 and IL20 induce airway inflammation have been considered.…”

Section: Discussionmentioning

confidence: 99%

IL10 Family Member Genes IL19 and IL20 Are Associated With Recurrent Wheeze After Respiratory Syncytial Virus Bronchiolitis

et al. 2011

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Mechanisms underlying the increased risk of recurrent wheeze after respiratory syncytial virus lower respiratory tract infection (RSV LRTI) are unclear. Specifically, information about genetic determinants of recurrent wheeze after RSV LRTI is limited. We performed a candidate gene association study to identify genetic determinants of recurrent wheeze after RSV LRTI. We investigated 346 single nucleotide polymorphisms (SNPs) in 220 candidate genes in 166 Dutch infants hospitalized for RSV LRTI. Logistic regression analysis was used to study associations between genotypes and haplotypes and recurrent wheeze after RSV LRTI. We found associations with recurrent wheeze for SNPs in IL19, IL20, MUC5AC, TNFRSF1B, C3, CTLA4, CXCL9, IL4R, and IL7 genes. Haplotype analysis of the combined IL19/IL20 genotyped polymorphisms demonstrated an inverse association between the TGG haplotype and recurrent wheeze after RSV LRTI. IL19 and IL20 genes were notably associated with recurrent wheeze in infants without asthmatic parents. The association of IL20 SNP rs2981573 with recurrent wheeze was confirmed in a healthy birth cohort. We concluded that genetic variation in adaptive immunity genes and particularly in IL19/IL20 genes associates with the development of recurrent wheeze after RSV LRTI, suggesting a role for these IL10 family members in the etiology of airway disease during infancy. (Pediatr Res 70: 518-523, 2011) R espiratory syncytial virus lower respiratory tract infection (RSV LRTI) during infancy is an independent risk factor for subsequent recurrent wheeze, at least within the first years of childhood (1). Mechanisms underlying the increased incidence of wheeze during the first years after RSV LRTI are unclear. Recurrent wheeze after RSV LRTI was related to signs of airflow limitation during RSV LRTI (2), eosinophilia during RSV LRTI (3), and monocyte IL10-production during the convalescent phase of RSV LRTI (4).To date, only two studies aimed to identify genetic determinants of recurrent wheeze after RSV LRTI. In one association study of 134 RSV hospitalized infants, a variant of the IL8 gene was related to the development of subsequent wheeze (5). We previously demonstrated an association between a functional IL13 polymorphism and wheeze at age 6, whereas no association was found between the IL13 polymorphism and recurrent wheeze during the first year after RSV LRTI (6).The availability of analytic tools to study larger numbers of genes and a larger cohort of RSV LRTI-hospitalized infants in whom recurrent wheeze was evaluated enabled us to extend our previous studies. Herein, we describe the results of 346 genotyped single nucleotide polymorphisms (SNPs) on 210 genes, including IL10 family genes. METHODS Subjects and design.The infants included in this study participated in previous studies (4,6 -8). In brief, they were hospitalized for RSV LRTI during the winter seasons of 1995-1996 or 2004 -2006. Infants included in the winter season of 1995-1996 participated in an observational study investigating the ...

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Section: Discussionmentioning

confidence: 99%

IL10 Family Member Genes IL19 and IL20 Are Associated With Recurrent Wheeze After Respiratory Syncytial Virus Bronchiolitis

et al. 2011

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“…Epithelial cells are the main target cells of IL-20 subfamily cytokines but they can also produce IL-19, IL-20 and IL-24 in response to cytokines secreted by immune cells [26][27][28][29][30][31] . Interestingly, IL-22 can induce IL-20 production by human and mouse keratinocytes 26,29 , suggesting the existence of an amplifying loop among IL-20 subfamily cytokines in the skin.…”

Section: Epithelial Cellsmentioning

confidence: 99%

The IL-20 subfamily of cytokines — from host defence to tissue homeostasis

Rutz¹,

Wang²,

Ouyang³

2014

Nat Rev Immunol

314

326

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The interleukin-20 (IL-20) subfamily of cytokines comprises IL-19, IL-20, IL-22, IL-24 and IL-26. These cytokines are all members of the larger IL-10 family, but have been grouped together to form the IL-20 subfamily based on their usage of common receptor subunits and similarities in their target-cell profiles and biological functions. Members of the IL-20 subfamily facilitate the communication between leukocytes and epithelial cells, thereby enhancing innate defence mechanisms and tissue repair processes at epithelial surfaces. In this Review, we describe the cellular sources and targets of the IL-20 subfamily cytokines, and we detail how their expression is regulated. Much of our understanding of the unique biology of this group of cytokines is still based on IL-22, which is the most studied member of the IL-20 subfamily. Nevertheless, we attempt a broader discussion of the emerging functions of IL-20 subfamily cytokines in host defence, inflammatory diseases, cancer and metabolism.

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“…However, there is no significant increase 362 in lung RORgt, between normal and control mice (Fig. 6B) neutralization inhibits Th2 disease [20,21]. Eotaxin-2 mRNA levels 375…”

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confidence: 94%

Chelidonine, a principal isoquinoline alkaloid of Chelidonium majus, attenuates eosinophilic airway inflammation by suppressing IL-4 and eotaxin-2 expression in asthmatic mice

Kim

Hong

Lee

2015

Pharmacological Reports

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Potentiation of IL-19 expression in airway epithelia by IL-17A and IL-4/IL-13: Important implications in asthma

Abstract: Background-IL-17A and IL-19 are highly expressed in chronic inflammatory diseases, such as psoriasis and asthma. IL-19 plays a significant role in the enhancement of T H 2 cytokine secretion in allergic diseases, but its cellular source in asthmatic patients remains unknown.

Cited by 97 publications

References 40 publications

IL10 Family Member Genes IL19 and IL20 Are Associated With Recurrent Wheeze After Respiratory Syncytial Virus Bronchiolitis

IL10 Family Member Genes IL19 and IL20 Are Associated With Recurrent Wheeze After Respiratory Syncytial Virus Bronchiolitis

The IL-20 subfamily of cytokines — from host defence to tissue homeostasis

Chelidonine, a principal isoquinoline alkaloid of Chelidonium majus, attenuates eosinophilic airway inflammation by suppressing IL-4 and eotaxin-2 expression in asthmatic mice

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