Potentiation of Lithium Toxicity by Ethanol in Rats and Mice

Ho, Andrew K.S.; Ho, C. C.

doi:10.1111/j.1530-0277.1978.tb04749.x

Cited by 10 publications

(1 citation statement)

References 20 publications

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“…K second problem is additive or synergistic effects of lithium and alcohol and an increase in lithium toxicity with both chronic and acute ethanol use (Cooper et al, 1974;Sinclair, 1979a;Ho & Ho, 1978;Hines & Henslee, 1986;Anton et al, 1985;Ostrow et al, 1986;Sharma & Rawat, 1986). It is possible that an increased lithium toxicity in alcoholics is also partially responsible for the poor compliance.…”

Section: Lithiummentioning

confidence: 99%

The Feasibility of Effective Psychopharmacological Treatments for Alcoholism

Sinclair

1987

British Journal of Addiction

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The effects of lithium, anxiolytics, dopaminergic compounds, serotonin uptake inhibitors, opiates, opiate antagonists, and alcohol-sensitizing drugs on the alcohol consumption of human alcoholics and laboratory animals are reviewed. There is increasing evidence that each of these classes of drugs might be beneficial in reducing alcohol abuse, including recent controlled studies on alcoholics with lithium, serotonin uptake blockers, and disulfiram. The usefulness of all ofthe current drugs, however, appears limited, and the ideal drug for use in treating alcoholism awaits discovery. Nevertheless, the fact that some drugs acting on the central nervous system are able to promote abstinence supports the feasibility of psychopharmacological treatment for alcoholism. Furthermore, since the known drugs that appear beneficial against human alcohol abuse also suppress voluntary alcohol selection by experimental animals, it seems likely that studies with animals could be used for screening other potentially effective drugs. dehyde, and liver aldehyde dehydrogenase relationships. Effects of ethyleneglycol dinitrate and related compounds on ethanol preference and ethanol metabolism, Acta Pharmacologica et Toxicologica, 35, pp. 145-154.

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Section: Lithiummentioning

confidence: 99%