Potentiation of the hypoglycaemic response to glipizide in diabetic patients by histamine H2‐receptor antagonists.

Feely, J.; Collins, Wanda; Cullen, Michael J.; Debani, A. H. El; MacWalter, Ronald S.; Peden, N. R.; Stevenson, I. H.

doi:10.1111/j.1365-2125.1993.tb05702.x

Cited by 16 publications

(6 citation statements)

References 12 publications

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“…In addition, histamine H1 receptor antagonist (pyrilamine) administered into the third ventricle suppresses hyperglycemia induced by intraventricular injection of neostigmine, whereas histamine H2 receptor antagonist (ranitidine) administration into the third ventricle enhances neostigmine-induced hyperglycemia [ 9 ]. Moreover, oral administration of histamine H2 receptor antagonists such as cimetidine or ranitidine potentiates the hypoglycemic response to glipizide in diabetic patients [ 10 ]. H2 receptor antagonist enhances alcohol-induced hypoglycemia [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

The Modulatory Role of Spinally Located Histamine Receptors in the Regulation of the Blood Glucose Level in D-Glucose-Fed Mice

Sim

Park

Kim

et al. 2014

Korean J Physiol Pharmacol

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The possible roles of spinal histamine receptors in the regulation of the blood glucose level were studied in ICR mice. Mice were intrathecally (i.t.) treated with histamine 1 (H1) receptor agonist (2-pyridylethylamine) or antagonist (cetirizine), histamine 2 (H2) receptor agonist (dimaprit) or antagonist (ranitidine), histamine 3 (H3) receptor agonist (α-methylhistamine) or antagonist (carcinine) and histamine 4 (H4) receptor agonist (VUF 8430) or antagonist (JNJ 7777120), and the blood glucose level was measured at 30, 60 and 120 min after i.t. administration. The i.t. injection with α-methylhistamine, but not carcinine slightly caused an elevation of the blood glucose level. In addition, histamine H1, H2, and H4 receptor agonists and antagonists did not affect the blood glucose level. In D-glucose-fed model, i.t. pretreatment with cetirizine enhanced the blood glucose level, whereas 2-pyridylethylamine did not affect. The i.t. pretreatment with dimaprit, but not ranitidine, enhanced the blood glucose level in D-glucose-fed model. In addition, α-methylhistamine, but not carcinine, slightly but significantly enhanced the blood glucose level D-glucose-fed model. Finally, i.t. pretreatment with JNJ 7777120, but not VUF 8430, slightly but significantly increased the blood glucose level. Although histamine receptors themselves located at the spinal cord do not exert any effect on the regulation of the blood glucose level, our results suggest that the activation of spinal histamine H2 receptors and the blockade of spinal histamine H1 or H3 receptors may play modulatory roles for up-regulation and down-regulation, respectively, of the blood glucose level in D-glucose fed model.

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Section: Introductionmentioning

confidence: 99%

The Modulatory Role of Spinally Located Histamine Receptors in the Regulation of the Blood Glucose Level in D-Glucose-Fed Mice

Sim

Park

Kim

et al. 2014

Korean J Physiol Pharmacol

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“…Total potential drug induced hypoglycemia 21 2 15 37 (reported with aspirin and indomethacin) and increasing the oral bioavailability of sulphonylureas through inhibition of metabolism (reported with ranitidine) [4][5][6][7][8][9][10][11].…”

Section: Discussionmentioning

confidence: 99%

“…PubMed search identified peered review papers providing evidence of drug interactions established to increase risk of hypoglycemia in persons with diabetes mellitus [4][5][6][7][8][9][10][11]. This information facilitated …”

mentioning

confidence: 99%

Potential Impairment of Hypoglycemic Control Associated with Drug Interactions: A Look at Closer Management Needs for Diabetes Mellitus

Gossell‐Williams¹,

Williams-Johnson²,

Leary³

2013

J Pharmacovigilance

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was the source of identification of all diabetes mellitus patients experiencing hypoglycemia and one senior consultant evaluated the patient medical records to help confirm presentation was associated with drug-induced hypoglycemia, as well as to confirm compliance with drug dosage instructions. The study protocol was approved by the UHWI/UWI/ FMS Ethics Committee.Data collected from the logbook, supported by patient docket included age, gender; name of drug implicated in the hypoglycemic episode and co-administered drug information. Direct patient communication was performed where necessary.PubMed search identified peered review papers providing evidence of drug interactions established to increase risk of hypoglycemia in persons with diabetes mellitus [4][5][6][7][8][9][10][11]. This information facilitated AbstractObjectives: One of the main adverse drug reactions presenting to emergency departments is drug induced hypoglycemia in diabetes mellitus patients. The aim of this study was to determine factors, other than lack of compliance with dietary requirements that could be increasing the risk of hypoglycemia among these patients.Methods: A prospective, observational study was conducted from September 2009 to January 2010 collecting information on all diabetes mellitus patients confirmed to be experiencing hypoglycemia presenting to the Accident and Emergency Department of The University Hospital of the West Indies. Data collected included name of drug implicated and co-administered drug information. Compliance with drug therapy was confirmed. Pubmed search conducted identified peered review papers providing evidence of drug interactions established to increase risk of hypoglycemia.Results: Eighteen patients were identified for the time period. Most patients (72.2%) were 65 years and older and most (66.7%) were also taking co-administered drugs. A total of 37 combinations in 12 of the patients known to potentiate hypoglycemia were identified. These included aspirin (13 cases), angiotensin converting enzyme inhibitors (12 cases) and beta-adrenoreceptor blockers (6 cases). Conclusions:Most of the patients presenting with drug induced hypoglycemia were at increased risk of experiencing this adverse event from their prescribed drug combinations. Therefore drug induced hypoglycemia in patients on antidiabetic therapy may not only be associated with non-compliance and patient assessment should review the risk of the combination to the maintenance of glycemic control.The significant finding of the study: Most of the diabetes mellitus patients presenting with drug induced hypoglycemia (66.7%) were on drug combinations with increased risk of this adverse drug reaction. This study provides evidence of a need for physicians to have easy access to drug interaction information that can facilitate assessment of risk to glycaemic control in diabetic mellitus patients. descriptive analysis of drug combinations among these patients that can increase their risk of hypoglycemia. Potential Impairment of Hypoglycemic

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“…Several compounds such as indobufen, cimetidine and ranitidine seem to inhibit the metabolie degradation of glipizide, subsequently increasing the average concentrations, i.e., by cimetidine of 23% and ranitidine of 34% WAHUN-BoLL 1980,1981;ELVANDER-STAHL et al 1984;FEELY et al 1993). Whereas nothing is known for indobufen, cimetidine has a broad inhibitory spectrum on several P450 enzymes.…”

Section: /) Pharmacokinetic Interactionsmentioning

confidence: 95%

Clinical Pharmacology of Sulfonylureas

Groop¹,

Neugebauer²

1996

Oral Antidiabetics

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Potentiation of the hypoglycaemic response to glipizide in diabetic patients by histamine H2‐receptor antagonists.

Cited by 16 publications

References 12 publications

The Modulatory Role of Spinally Located Histamine Receptors in the Regulation of the Blood Glucose Level in D-Glucose-Fed Mice

The Modulatory Role of Spinally Located Histamine Receptors in the Regulation of the Blood Glucose Level in D-Glucose-Fed Mice

Potential Impairment of Hypoglycemic Control Associated with Drug Interactions: A Look at Closer Management Needs for Diabetes Mellitus

Clinical Pharmacology of Sulfonylureas

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