1966
DOI: 10.2105/ajph.56.12.2106
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Potentiation of tissue culture rabies vaccine by adjuvants.

Abstract: The results presented in the following paper indicate that a tissue culture rabies vaccine prepared according to specified criteria and potentiated by aluminum adjuvants proved effective in animals challenged with street rabies virus. The authors believe this merits immunization trials in man.

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Cited by 17 publications
(7 citation statements)
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“…Additional study is needed to develop further the described method so as to allow the determina-VOL. 6,1972 485 on August 1, 2020 by guest http://iai.asm.org/ Downloaded from tion of the degree of protection against rabies in a single serum sample. This seems to be possible by the application of a comparative assay in which an unabsorbed part of the serum is tested against another portion, absorbed with viral antigen.…”
Section: Resultsmentioning
confidence: 99%
“…Additional study is needed to develop further the described method so as to allow the determina-VOL. 6,1972 485 on August 1, 2020 by guest http://iai.asm.org/ Downloaded from tion of the degree of protection against rabies in a single serum sample. This seems to be possible by the application of a comparative assay in which an unabsorbed part of the serum is tested against another portion, absorbed with viral antigen.…”
Section: Resultsmentioning
confidence: 99%
“…(i) The CVS strain of fixed rabies virus, diluted to contain 100 to 200 mouse LD50 per 0.03 ml, was mixed with equal amounts of either interferon pool B or with serum from uninoculated rabbits (control). After incubation of these sets at 37 C for 1.5 hr, the standard mouse test for the determination of rabies virus-neutralizing antibodies was performed as in a previous study (7). No neutralizing activity to CVS was detected in either rabbit serum.…”
Section: Resultsmentioning
confidence: 99%
“…MATERIALS AND METHODS The rabies street virus originated from a naturally infected fox (7). The virus suspension was stored as a 10% homogenate of the salivary gland and contained 8,000rabbit intramuscular (im) LD5o per 0.4 ml.…”
mentioning
confidence: 99%
“…The Street-Alabama-Dufferin (SAD) strain, which was developed using hamster kidney cells, has been used to produce MLV vaccines [8,9]. Although modified live rabies vaccine strains (ERA, Flury, and SAD) are safe and potent in dogs, the WHO stopped recommending MLV rabies vaccines for parenteral inoculation in animals in 2004.…”
Section: Current Rabies Vaccinesmentioning
confidence: 99%