Potentiometric and Spectroscopic Studies of Sulfonamide Azo-Dye Complexes with some Transition Metal Ions and Uranium

Abstract

Molecular structure of the azo-dye derived from sulfonamide was synthesized. The elucidation of ligand and complex structures were studied by electronic, infrared and 1H NMR spectroscopies. Proton-ligand constants of sulphonamid azo-derivatives and the stability constant of Mo (III), VO (II), UO 2 (II) and Co (II) metal ions with sulfonamide azodye derivatives have been determined potentiometrically in 0.1 M KCl and 30% (v/v) ethanol-water mixture. The data are discussed in terms of the electronic character of the substituents and of the change in temperature. The pK 1-H values have been found to increase with increasing electron donating nature of the subsituents. The evaluated dissociation processes are non spontaneous, endothermic and entropically unfavourable. The order of the stability constants of the formed complexes was found to be Mo 3+ > VO 2+ > UO 2 2+ > Co 2+ . The influence of substituents on the stability of the complexes was examined on the basis of an electron repelling property of the substituent. The effect of temperature on the stability of the formed complexes was studied and the corresponding thermodynamic parameters (∆G, ∆H and ∆S) were evaluated and discussed. The stoichiometries of these complexes were determined conductometrically and indicated the formation of 1:1 and 1:2 (metal:ligand) complexes.

Antimicrobial sulphonamide azo dyes

“…Sulphonamides have long been used as drugs to treat leprosy, malaria, diabetes, cancer and tuberculosis, but more importantly in the context of this review, sulphonamide and azo‐sulphonamide derivatives have utility as ligands for a variety of metal cations …”

“…[24][25][26] Sulphonamide derivatives inhibit CA through coordination of their SO 2 NH anion with the Zn 2+ cation of the enzyme, leading to a reduction in HCO − 3 synthesis in the transition state required for CA to function. 18,24 Sulphonamides have long been used as drugs to treat leprosy, malaria, diabetes, cancer and tuberculosis, 27 but more importantly in the context of this review, sulphonamide and azo-sulphonamide derivatives have utility as ligands for a variety of metal cations. [28][29][30][31][32] Among the drug families mentioned above, antibiotics are the most concerning because their high consumption and environmental release are the main causes of the spread of bacterial antibiotic resistance worldwide.…”

Synthesis of Novel Sulfamethaoxazole 4-Thiazolidinone Hybrids and Their Biological Evaluation

“…A literature survey revealed that sulfonamide derivatives are endowed with numerous therapeutic activities as anticonvulsants, HIV protease inhibitors, and antitumor agents [ 31 ]. Sulfonamide derivatives are also used for treating certain forms of malaria, urinary tract infections, erectile dysfunction [ 32 ] as well as use as herbicides and dyes [ 33 ]. Isoxazole derivatives also possess various interesting pharmacological properties.…”

Density functional theory/B3LYP study of nanometric 4‐(2,4‐dihydroxy‐5‐formylphen‐1‐ylazo)‐N‐(4‐methylpyrimidin‐2‐yl)benzenesulfonamide complexes: Quantitative structure–activity relationship, docking, spectral and biological investigations

“…Furthermore, sulfonamides and azodye derivatives of sulfonamides were found to have a variety of biological properties such as anti‐tubercular, anticancer and antimalarial activities . Many sulfonamide azodye derivatives are usually applied as powerful ligands for a vast range of transition metal ions . The metal chelates find many applications in biological systems, dying processes and analytical detection of various metal ions .…”