Potentiometric detection of apomorphine in human plasma using a 3D printed sensor

Elhassan, Manar M.; Glasco, Dalton L.; Sheelam, Anjaiah; Mahmoud, Amr M.; Hegazy, Maha A.; Mowaka, Shereen; Bell, Jeffrey G.

doi:10.1016/j.bios.2023.115971

Biosensors and Bioelectronics

2024

DOI: 10.1016/j.bios.2023.115971

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Potentiometric detection of apomorphine in human plasma using a 3D printed sensor

Manar M. Elhassan,

Dalton L. Glasco,

Anjaiah Sheelam

et al.

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2024

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Cited by 4 publications

(2 citation statements)

References 49 publications

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“…For example, several ion-selective membranes have been reported utilizing unique 3D printable cocktails to selectively detect various blood electrolytes, pharmaceuticals, and biomarkers. [36][37][38] Recently, commercial carbon-infused thermoplastic filament has been propelled into the field of electrochemical sensing utilizing fused deposition modeling (FDM) 3D printing. FDM printing fabricates 3D structures out of thermoplastic polymer filaments such as polylactic acid (PLA) and acrylonitrile butadiene styrene (ABS).…”

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confidence: 99%

Nonenzymatic Detection of Glucose Using 3D Printed Carbon Electrodes in Human Saliva

Glasco,

Elhassan,

McLeod

et al. 2024

ECS Sens. Plus

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One of the most prevalent diseases where point-of-care (POC) diagnostics has focused is diabetes, which impacts hundreds of millions of people globally. Due to the severe negative outcomes including renal failure, nerve damage, and stroke, many POC sensors have been designed to streamline low-cost testing. Recently, the utility of 3D printing for rapidly fabricating housings, electrodes, and sensors for use at the POC has been exploited toward diverse applications. Particularly interesting are 3D printed carbon electrodes (3DpCEs) in POC diagnostics owing to their simplicity, affordability, and mass production capabilities for developing sensors either for direct use or through post-printing surface modifications. Herein, we report a copper modified 3DpCE as a sensitive and selective nonenzymatic biosensor for glucose. Copper deposition, paired with an optimized activation protocol, produced a sensitive and selective sensor for glucose with a larger detection range, enhanced sensitivity, and better reproducibility compared to nonactivated and alkaline immersed 3DpCEs. The sensor displayed excellent linearity between 10-1800 µM and proved to be highly selective over common biologically relevant interferants. The 3D printed sensor successfully determined biologically relevant concentrations of glucose in human saliva which resulted in percent recoveries of 101+8%, 106+6%, and 98+6% for 74, 402, and 652 µM glucose, respectively

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confidence: 99%

Nonenzymatic Detection of Glucose Using 3D Printed Carbon Electrodes in Human Saliva

Glasco,

Elhassan,

McLeod

et al. 2024

ECS Sens. Plus

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“…[1][2][3] In this context, numerous ionselective electrodes (ISEs) have been fabricated and successfully used in the pharmaceutical field for the direct assay of drugs in dosage forms and biological matrices. [4][5][6][7][8][9][10][11][12] Membrane electrodes can also be used directly in tablet content uniformity determination, degradation kinetics, and dissolution profile research. 13,14 The selective electrode's ability to continuously monitor the active constituent's concentration in the standardized dissolution cells is a benefit of using this electrode technique for these kinds of tests.…”

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confidence: 99%

Solid-State Microfabricated Potentiometric Sensors for Selective Assessment of Diclofenac Sodium Utilizing Pentafluorophenyl Diazonium Modified Carbon Nanotubes Transducer Layer

Sami,

Monir,

Mahmoud

et al. 2024

J. Electrochem. Soc.

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In the pharmaceutical field, analytical chemistry is evolving and one area that is experiencing enthusiasm is the design and implementation of solid contact ion-selective electrodes. We have developed two potentiometric sensors for the selective assay of a widely used drug diclofenac sodium. Diclofenac sodium was targeted in one of its most recommended dosage forms (Arthrotec® tablets) in the presence of misoprostol. A cost-effective copper printed circuit board as a substrate has been coated with a PVC sensing membrane to fabricate sensor I. Hydrophobic carbon nanotubes (CNTs) have been modified through in situ reduction of pentafluorophenyl diazonium using sodium borohydride. An interlayer of the modified CNTs was inserted as a transducer layer between the Cu substrate and the ion-sensing membrane in sensor II to enhance its electrochemical performance and stability. The microfabricated electrodes demonstrated encouraging outcomes upon the direct assay of diclofenac sodium in combination with misoprostol and other additives without sample preparation steps. The responses presented a linear Nernstian pattern in the range of 1.0 × 10−4 to 1.0 × 10−2 mol l−1 with a slope of −58.2 and −58.4 mV/decade for sensors I and II, consequently. Finally, the sustainability of the developed technique was assured using advanced green metrics.

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Integration of 3D printed Mg²⁺ potentiometric sensors into microfluidic devices for bioanalysis

Farahani,

Glasco,

Elhassan

et al. 2024

Lab Chip

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Potentiometric detection of apomorphine in human plasma using a 3D printed sensor

Cited by 4 publications

References 49 publications

Nonenzymatic Detection of Glucose Using 3D Printed Carbon Electrodes in Human Saliva

Nonenzymatic Detection of Glucose Using 3D Printed Carbon Electrodes in Human Saliva

Solid-State Microfabricated Potentiometric Sensors for Selective Assessment of Diclofenac Sodium Utilizing Pentafluorophenyl Diazonium Modified Carbon Nanotubes Transducer Layer

Integration of 3D printed Mg²⁺ potentiometric sensors into microfluidic devices for bioanalysis

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Potentiometric detection of apomorphine in human plasma using a 3D printed sensor

Cited by 4 publications

References 49 publications

Nonenzymatic Detection of Glucose Using 3D Printed Carbon Electrodes in Human Saliva

Nonenzymatic Detection of Glucose Using 3D Printed Carbon Electrodes in Human Saliva

Solid-State Microfabricated Potentiometric Sensors for Selective Assessment of Diclofenac Sodium Utilizing Pentafluorophenyl Diazonium Modified Carbon Nanotubes Transducer Layer

Integration of 3D printed Mg2+ potentiometric sensors into microfluidic devices for bioanalysis

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Integration of 3D printed Mg²⁺ potentiometric sensors into microfluidic devices for bioanalysis