Potentiometric determination of mephedrone in oral fluids with ion‐selective membranes

Abstract

This work presents a potentiometric approach for the detection of two cathinone derivatives, namely mephedrone (4‐MMC) and clephedrone (4‐CMC). Contrary to neutral‐carriers (dibenzo‐18‐crown‐6‐ether and calix[4]arene), cation‐exchanger (tetraphenylborate sodium) as active component of ion‐selective membrane showed near‐Nernstian response (+47 mV/decade from 1.7 ⋅ 10−6 to 5.6 ⋅ 10−4 mol l−1) and selectivity for 4‐MMC in oral fluids (OF). The agreement between the quantitative results obtained with the potentiometric approach and the HPLC/MS‐MS method determination of 4‐MMC in OF shows the potential of the proposed potentiometric approach for forensic analysis.

Zwitterionic oligomers of 3-aminobenzoic acid on screen-printed electrodes: structure, properties and forensic application

“…Molecular imprinted polymers have gained popularity over the last two decades for the determination of SCs. 13,14,23 Moreover, the selectivity of the modified electrodes enables their applicability in biological samples (blood serum, 14 plasma, urine 13,21 and oral fluids 9 ). Additionally, electrochemically synthesized polymers with recognition sites have contributed to the development of electrochemical sensors that have found various applications.…”

“…6,7 Table 1 presents the progress in the use of electrochemistry for the detection of SCs. Although the use of potentiometry with ion-selective electrodes has been reported, [8][9][10] most of the electrochemical methods used in these studies were voltammetric methods based on the use of different unmodified and modified electrodes. 5,[11][12][13][14][15][16][17][18][19][20][21][22] The use of unmodified working electrodes often leads to overlapping signals of structural analogues, and therefore limits the selectivity of voltammetric detection.…”

A Novel Polymeric Membrane Sensor for Chlorhexidine Determination

“…Recently, potentiometric chemical sensors have been prepared and investigated for the determination of compounds such as isoniazid, gabapentin, lidocaine, cysteamine, pyridoxine, memantine, and fluconazole [2]; alogliptin, saxagliptin, and vildagliptin [3]; tetracycline HCl and metronidazole [4]; safinamide [5]; mephedrone [6]; and many others. The developed ISEs were successfully used for analytical determinations of pharmaceutical and natural samples with high recovery factors.…”