Potentiometric determination of the dissociation constants of epirubicin HCl and irinotecan HCl

Determination of Dissociation Constants of Folinic Acid (Leucovorin), 5-Fluorouracil, and Irinotecan in Hydro-organic Media by a Spectrophotometric Method

“…The dissociation constant values determined for the equilibria involved for the studied compounds in water, 0.10, 0.20, 0.30, 0.40, and 0.50 volume fraction MeCN−water mixtures at (25.0 ± 0.1) °C, are collected in Table , together with respective standard deviations. p K values reported in the literature for water are also shown in Table . – …”

“…pK values reported in the literature for water are also shown in Table 1. [16][17][18] LV is a 5-formyl derivative of tetrahydrofolic acid (Figure 1). LV behaves as a weak acid owing to the dissociation of the phenolic OH in the pteridine ring moiety and two carboxylic groups in the glutamic acid moiety.…”

“…The p K a values of these compounds are either not known accurately or not available at all. Only a limited number of studies on the p K values of these compounds are found in the literature. – This paper focuses on the determination of p K a values of LV, 5-FU, and irinotecan in water and several MeCN−water mixtures, 0.10, 0.20, 0.30, 0.40, and 0.50 volume fraction at an ionic strength equal to 0.1 mol·L −1 with KCl, to overcome the lack of information related to the acid−base equilibria of this kind of compound by means of spectrophotometric measurements.…”

Pharmaceutical compound removal efficiency by a small constructed wetland located in south Brazil

“…These compounds are known to be highly reactive represents a risk to human health and the environment. (Anilanmert et al 2006); e drugbank.ca ; f drugfuture.com; *phenol Biofilm extraction procedure was performed using the method described by Aubertheau et al, (2017). Five hundred milligrams of dry weight biofilms were extracted by extraction liquid at high pressured (ASETM 350, Thermo Fisher Scientific Inc, Waltham, USA) at 80 °C using methanol / water (1/2; v/v) as the extraction solvent.…”

pKa Constant of Varenicline

“…The p K a is also important in choosing the optimum conditions in the development of analysis methods for drug molecules. Acid dissociation constant determination studies were performed for many drugs like irinotecan HCl , and epirubicin HCl, leucovorin, 5-fluorouracil, montelukast sodium, levodropropizine, mupirocin, and many other drugs such as antiinflammatories, antibiotics, β-blockers, and so forth.…”