Potentiometric determination of the neurotransmitter acetylcholine with ion-selective electrodes containing oxatub[4]arenes as the ionophore

Chen, Qinghan; Yang, Liu‐Pan; Li, Dong‐Hao; Zhai, Jingying; Jiang, Wei; Xie, Xiaojiang

doi:10.1016/j.snb.2020.128836

Cited by 25 publications

(14 citation statements)

References 49 publications

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“…Besides it is highly hydrophobic which causes a strong response in the ISE. That’s why (Pen) 4 N + Br − was selected as a reference ion, as previously employed in literature [ 4 , 27 , 32 , 33 ]. For ensuring the most selective ionophore for MDZ the response of ISEs doped with different ionophores was compared to (Pen) 4 N + Br − .…”

Section: Resultsmentioning

confidence: 99%

Fabrication of novel electropolymerized conductive polymer of hydrophobic perfluorinated aniline as transducer layer on glassy carbon electrode: application to midazolam as a model drug of benzodiazepines

et al. 2023

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The objective of this study is to fabricate solid-contact ion selective electrodes (SC-ISEs) that have long term stable potential. Various conducting polymers such as polyaniline and its derivatives have been successfully employed to improve the potential stability in SC-ISEs. Recently, the role of hydrophobicity at the interface between the conducting polymer solid contact and the ion sensing membrane has been investigated and figured out that the hydrophobic interfaces preclude water layer formation that deteriorate the SC-ISEs potential stability and reproducibility. In this work, a hydrophobic polyaniline derivative was fabricated on the surface of a glassy carbon electrode by electropolymerization of perfluorinated aniline monomers in acidic solution. The electropolymerized hydrophobic polymer was characterized by electrochemical impedance spectroscopy and X-ray photoelectron spectroscopy. The fabricated electrode was employed for determination of midazolam—a model drug-in pharmaceutical formulation without prior extraction. The SC-ISEs performance was optimized, and the potential drift was compared to control SC-ISEs, the SC-ISE linear range was 1 × 10–6–1 × 10–2 M, LOD was estimated to be 9.0 × 10–7 M, and potential drift was reduced to 100 μV/h.

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Section: Resultsmentioning

confidence: 99%

Fabrication of novel electropolymerized conductive polymer of hydrophobic perfluorinated aniline as transducer layer on glassy carbon electrode: application to midazolam as a model drug of benzodiazepines

et al. 2023

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“…An ISE prepared with a naphthocage receptor demonstrated a reproducible linear response in the concentration range from 10 –6 to 10 –3 M with a super-Nernstian slope of 85 mV/decade. Jiang and Xie’s groups explored another class of synthetic receptors, oxatub[4]arenes, as an ionophore for the potentiometric detection of acetylcholine . Three oxatub[4]arenes with different attached aliphatic chains were studied.…”

Section: Sensor Materialsmentioning

confidence: 99%

“…Jiang and Xie's groups explored another class of synthetic receptors, oxatub [4]arenes, as an ionophore for the potentiometric detection of acetylcholine. 152 Three oxatub [4]arenes with different attached aliphatic chains were studied. The oxatub [4]arene with normal butyl chains was identified to provide the best selectivity to acetylcholine.…”

Section: Mittal Et Al Synthesized and Tested An Imine-based Ligand (E...mentioning

confidence: 99%

Potentiometric Sensing

2020

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“…In boric compounds, the boronic center can bind with the NH + 3 group of PEA through a dative B-N bond, which is much stronger than the covalent bond formed between boronic acid and vicinal diols in catecholamine [27,35]. Besides, the hydrophobic property of carboxyphenylboronic acid reduces the ionophore leakage from the sensing membrane into an aqueous sample [36]. Therefore, we envisage that 4-carboxyphenylboronic acid is a favorable ionophore for PEA determination.…”

Section: Introductionmentioning

confidence: 98%

Solid-contact ion-selective electrodes for potentiometric determination of phenylethylamine in vitro

Wang

Jiang

et al. 2021

Meas. Sci. Technol.

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The implementation of all-solid-state ion-selective electrodes for phenylethylamine (PEA) determination is described in this paper. The electrode was constructed using 4-carboxyphenylboric acid as an ionophore, potassium tetrakis[3,5-bis(trifluoromethyl)p-henyl]borate as an ion exchanger and 2-nitrophenyl octyl ether as a plasticizer in the selective polymeric membrane. The solid-contact conductive layer between the polymer layer and gold wire (0.5 mm diameter) was fabricated by electro polymerizing poly (3,4-ethylene dioxythiophene) doped with polystyrene sulfonate (PEDOT/PSS) for ion-to-electron transfer. The electrode exhibited a near-Nernstian response to PEA with the detection limit of 1 µM and stable responses in the pH operation range of 7.0–8.0 as well as the temperature range of 20 ∘C–40 ∘C. Experiments were carried out to investigate the response time, selectivity to common cations, reproducibility and life span of the developed electrodes. Fast response time of less than 8 s, good reproducibility and long-term stability were achieved by the electrodes. In addition, the electrode was tested in human plasma as background by using the standard addition method. The recovery rate close to 100% at 10−5 M PEA solution indicated the possibility to determine PEA in biologic fluids and pharmaceutical analyses.

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Potentiometric determination of the neurotransmitter acetylcholine with ion-selective electrodes containing oxatub[4]arenes as the ionophore

Cited by 25 publications

References 49 publications

Fabrication of novel electropolymerized conductive polymer of hydrophobic perfluorinated aniline as transducer layer on glassy carbon electrode: application to midazolam as a model drug of benzodiazepines

Fabrication of novel electropolymerized conductive polymer of hydrophobic perfluorinated aniline as transducer layer on glassy carbon electrode: application to midazolam as a model drug of benzodiazepines

Potentiometric Sensing

Solid-contact ion-selective electrodes for potentiometric determination of phenylethylamine in vitro

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