Potentiometric titration of long chain quaternary ammonium compounds using sodium tetraphenyl borate

Wang, C. N.; Metcalfe, L.; Donkerbroek, J. J.; Cosijn, A.H.M.

doi:10.1007/bf02660757

Cited by 4 publications

(1 citation statement)

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“…Metcalfe et al (4) titrated quats with tetraphenyl boron (TPB) using dichlorofluoroscein as a visual indicator. Wang et al (5) improved Metcalfe's method by titrating with TPB potentiometrically using platinum-platinum electrodes.…”

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Assay of quaternary ammonium antimicrobial compounds by aqueous potentiometric titration

Battaglini

2002

J Surfact & Detergents

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An automatic potentiometric titration method for the determination of quaternary ammonium antimicrobial compounds at the macro level is described. The procedure involves the use of standard sodium lauryl sulfate as the titrant and a nitrate ion-selective or surfactant electrode to detect the end point. The method, which includes a new, simpler means of titrant standardization, avoids the use of hazardous solvents such as chloroform, which are employed in two-phase titration methods currently in common use. In this study, four frequently produced antimicrobial quats were titrated potentiometrically and by a two-phase titration using bromphenol blue as the indicator. Comparison of results shows the automatic potentiometric method to be accurate, more precise, easier, faster, and generally better suited for use in a production laboratory than the two-phase approach. The nitrate and the surfactant electrodes appear to be equal in performance.Paper no. S1240 in JSD 5, 117-121 (April 2002).KEY WORDS: Automatic titrator, boric acid buffer, Hyamine ® 1622, nitrate ion selective electrode, sodium lauryl sulfate, surfactant electrode, two-phase titration.Quaternary ammonium antimicrobial compounds (referred to herein as quats) are widely used as hard-surface disinfectants, deodorizers, fungicides, algicides, slimicides, and sanitizers in households, nursing homes, hospitals, building maintenance, public institutions, cooling water applications, and food processing. The production of these quats requires analytical methods for their assay that are fast and accurate for process and quality control and to ensure final product compliance to specifications. With today's emphasis on safety and ecological concerns, it is also imperative that the methods avoid the use of solvents that are hazardous to laboratory workers or to the environment. A number of methods have been proposed over the years for assaying quats. A colorimetric procedure based on the reaction of the cationic salt with an anionic dye, extraction of the dye complex with chloroform, and measurement of the color absorbance with a spectrophotometer was reported by Auerbach (1). The method has proven to be useful at lower (ppm) levels but not at macro levels. Probably the most commonly used method is a modification of the one originally described by Epton (2). This is a twophase (chloroform and water) titration with a standard sodium lauryl sulfate (SLS) solution using a high pH (about 11) sodium carbonate buffer and a bromphenol blue indicator end point. Some operators have found the procedure difficult for control purposes. Moreover, chloroform has been classified as an industrial substance with suspected carcinogenic potential for humans by the American Council of Governmental Industrial Hygienists (3). Metcalfe et al. (4) titrated quats with tetraphenyl boron (TPB) using dichlorofluoroscein as a visual indicator. Wang et al. (5) improved Metcalfe's method by titrating with TPB potentiometrically using platinum-platinum electrodes.In ASTM method D-4251-89 (6), anio...

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