Potenzial von Prozessintegration mit Adsorbern zur Herstellung seltener Monosaccharide – eine modellbasierte Untersuchung

Bechtold, Matthias; Füreder, Markus; Wagner, Nina; Panke, Sven

doi:10.1002/cite.200900149

Cited by 4 publications

(5 citation statements)

References 51 publications

(31 reference statements)

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“…Bechtold et al investigated its potential with respect to enzyme-catalyzed racemizations to produce amino acids [2,3]. Zhang et al [4] evaluated it for the production of high-fructose syrup.…”

Section: Introductionmentioning

confidence: 98%

Integrated Simulated Moving Bed Processes for Production of Single Enantiomers

2011

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Based on the assumption of true moving bed processes it was demonstrated that integration of a racemization reaction into a continuous chromatographic process can improve the production of single enantiomers. In view of possible practical implementations, the analysis is extended to more realistic simulated moving bed (SMB) processes. Superstructures of SMB-based systems are defined that reflect the three general concepts of flow sheet, partial, and total process integration. Process candidates are generated by simultaneously optimizing process structure and operating conditions. Optimal process setups are determined under idealized conditions as a function of the purity requirement. The best performance is achieved by fully integrated processes. These are compared under more realistic conditions to units with side reactors. The results indicate that a simple fully integrated SMB system with three zones is a particularly promising new process option. The new concept is investigated in detail to identify relevant practical aspects.

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Section: Introductionmentioning

confidence: 98%

Integrated Simulated Moving Bed Processes for Production of Single Enantiomers

2011

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“…Dabei handelt es sich im Wesentlichen um theoretische Untersuchungen, die aufzeigen, dass die Produktabtrennung zur signifikanten Produktivitätssteigerung kontinuierlich erfolgen muss. Einen wesentlichen Einfluss auf die Ausbeute haben neben der Selektivität des Adsorbens erwartungsgemäß auch die maximale Beladung sowie die Kinetik der Enzyme [17]. Weitere Arbeiten zur reaktionsintegrierten Adsorption behandeln Proteine, Antibiotika und Sekundär-metabolite [23].…”

Section: Reaktionsintegrierte Produktabtrennungunclassified

“…Durch die reaktionsintegrierte Extraktion konnte die Ausbeute erhöht und die Nebenproduktbildung um 28 % reduziert werden [36], jedoch liegen keine Extraktionsdaten zu Zwischenprodukten im Syntheseweg vor. Darüber hinaus gibt es theoretische Arbeiten zur reaktionsintegrierten Adsorption und Chromatographie bei monoenzymatischen Gleichgewichtsreaktionen [17], welche jedoch auch keine Co-Adsorption von Zwischenprodukten in einem Mehrenzymsystem berücksichtigen.…”

Section: Prozesssimulationunclassified

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Simulation of Reaction Integrated Adsorption of Trienzymatic Synthesized Laminaribiose

Waluga

Zein

Jördening

et al. 2013

Chemie Ingenieur Technik

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Simulation of Reaction Integrated Adsorption of Trienzymatic Synthesized LaminaribioseA simulation for the reaction integrated adsorption of trienzymatic synthesized laminaribiose was created, based on three individual enzymatic kinetics and equilibrium data from pure substance measurements. A discontinuous integration of reaction and adsorption was able to increase the yield by one third. A continuous adsorption with a cyclic transfer of loaded and replacement with fresh adsorbent can increase the yield by even 2.4 times. However, if the replacement cycle of the adsorbent is too short, the discharge of intermediates results in a reduced product formation.

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“…A general property that makes the latter biotransformations less attractive for industrial-scale application is the frequent unfavourable position of the thermodynamic equilibrium of the catalysed reactions, typically restricting possible product yields in batch reactions to between 20 and 70% (Bechtold et al, 2006). However, instead of performing reaction and separation in subsequent steps, integrated operation of both steps can help to significantly enhance the process yield (Bechtold et al, 2010). This is achieved by directly separating the product upon its formation from the reaction mixture, allowing to shift the equilibrium to the product side and running the equilibrium reaction close to completion (Woodley et al, 2013).…”

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confidence: 97%