Potyviral HC-Pro: a multifunctional protein

Expression of functionally active helper component protein of Tobacco etch potyvirus in the yeast Pichia pastoris

“…In the case of HC-Pro, its involvement in many important functions (Maia et al, 1996;UrcuquiInchima et al, 2001) has precluded the systematic use of mutagenesis, for instance to study the aphid transmission process. In the case of TEV, the N-terminal residues of HCPro are dispensable for systemic infection, although their deletion affected transmissibility (Dolja et al, 1993).…”

Potyvirus helper component-proteinase and coat protein (CP) have coordinated functions in virus-host interactions and the same CP motif affects virus transmission and accumulation.

“…The helper component-proteinase (HC-Pro) (Maia et al, 1996) and coat protein (CP) (Shukla et al, 1994 ;Mahajan et al, 1996) are examples of multifunctional potyvirus proteins (Fig. 1 a).…”

A Violaxanthin Deepoxidase Interacts with a Viral Suppressor of RNA Silencing to Inhibit Virus Amplification

“…HC-Pro also participates in symptom development, genome replication, and virus movement (Maia et al, 1996;Syller, 2006), whereas these capacities should be derived from its ability to suppress RNA silencing (Kasschau and Carrington, 2001;Díaz-Pendón and Ding, 2008). Furthermore, HC-Pros from different viruses have been reported to interact with various host factors and affect their functions, such as the ubiquitin/26S proteasome system (Ballut et al, 2005), the chloroplast precursor of ferredoxin-5 (Cheng et al, 2008), and chloroplast protein 1-deoxy-D-xylulose-5-phosphate synthase (Li et al, 2015).…”