2020
DOI: 10.1038/s41598-020-57425-9
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POU domain motif3 (Pdm3) induces wingless (wg) transcription and is essential for development of larval neuromuscular junctions in Drosophila

Abstract: Wnt is a conserved family of secreted proteins that play diverse roles in tissue growth and differentiation. Identification of transcription factors that regulate wnt expression is pivotal for understanding tissue-specific signaling pathways regulated by Wnt. We identified pdm3 m7 , a new allele of the pdm3 gene encoding a POU family transcription factor, in a lethality-based genetic screen for modifiers of Wingless (Wg) signaling in Drosophila. Interestingly, pdm3 m7 larvae showed slow locomotion, implying ne… Show more

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Cited by 6 publications
(15 citation statements)
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“…We previously identified suppressors that overcome lethality induced by overexpressed Sona in a genetic screen 17 . A suppressor m7 had two lethal sites and one of them was present in pdm3 as reported 16 . Pdm3 induces wg transcription and is essential for the development of neuromuscular junctions 16 .…”
Section: Resultsmentioning
confidence: 85%
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“…We previously identified suppressors that overcome lethality induced by overexpressed Sona in a genetic screen 17 . A suppressor m7 had two lethal sites and one of them was present in pdm3 as reported 16 . Pdm3 induces wg transcription and is essential for the development of neuromuscular junctions 16 .…”
Section: Resultsmentioning
confidence: 85%
“…A suppressor m7 had two lethal sites and one of them was present in pdm3 as reported 16 . Pdm3 induces wg transcription and is essential for the development of neuromuscular junctions 16 . The other lethal site was mapped to the region deleted in two deficiencies, Df(2R)BSC273 and Df(2R)BSC274 (Fig.…”
Section: Resultsmentioning
confidence: 85%
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“…Consistent with this, RNA-seq analyses revealed a number of genes that were similarly dysregulated in the VNC of kdm5 JmjC* and kdm5 L854F larvae. This included diminished expression of wingless, which can result in reduced bouton number and slowed larval locomotion (Kim and Cho, 2020). Alternatively, the locomotor phenotype observed in kdm5 JmjC* and kdm5 L854F larvae may not be caused by NMJ perturbations but may instead be indirectly caused by aberrant neurotransmission in upstream motor networks.…”
Section: Discussionmentioning
confidence: 99%