Over the past 40 years, the field of Andean paleopathology has developed considerably, tackling broad research questions on the health and disease patterns of Prehispanic Andean populations while relying on ever evolving and improving theoretical and methodological research models. However, commingled skeletal assemblages recovered from collective tombs and looted contexts have rarely been at the center of these theoretical and methodological advancements in Andean paleopathology despite their widespread presence throughout the Prehispanic Andes. While recent studies have shown that these looted contexts can still produce valuable data, very few of them have focused on paleopathology and no such studies exist for the Cordillera Negra region of Peru. Therefore, this study represents the first systematic paleopathological analysis of a Prehispanic commingled skeletal assemblage from this region, dating to the Late Intermediate Period (1000 -1480 AD). In addition to providing new information regarding the types of diseases the people interred in those funerary structures suffered from (including degenerative joint diseases, infectious diseases, metabolic diseases, trauma, developmental anomalies, and a probable case of a neoplasm), the present research demonstrates the potential and feasibility of undertaking rigorous paleopathological analyses of these challenging contexts. Indeed, the use of detailed excavation and laboratory methodologies, the integration of relevant taphonomical information, and the creation of an extensive relational database enabled reassociation of multiple bone elements based on bioarchaeological and paleopathological evidence, thus aiding in the elaboration of differential diagnoses and more generally in the interpretation of these commingled contexts. v identified skeletal collection .