Pourquoi le taux de mutation n’est-il jamais égal à zéro ?

Casañe, Didier; Policarpo, Maxime; Laurenti, Patrick

doi:10.1051/medsci/2019030

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…The length of CoV genomes is about 30,000 nucleotides, which is exceptionally long for an RNA virus. (By comparison, the length of AIDS and Ebola virus genomes is about 10,000 and 19,000 nucleotides, respectively) CoVs are able to maintain such a long genome thanks to a replication error correction system unique in the world of RNA viruses that ensures a proofreading mechanism limiting the mutation rate (Eckerle et al 2010 ; Ferron et al 2018 ; Casane et al 2019 ). The first two-thirds of the genome corresponds to a single gene, ORF1ab, coding for a polyprotein precursor, which is then cleaved into 16 proteins forming the replication/transcription complex.…”

Section: An Evolutionary History By Fragmentsmentioning

confidence: 99%

Tracing the origins of SARS-COV-2 in coronavirus phylogenies: a review

et al. 2021

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SARS-CoV-2 is a new human coronavirus (CoV), which emerged in China in late 2019 and is responsible for the global COVID-19 pandemic that caused more than 97 million infections and 2 million deaths in 12 months. Understanding the origin of this virus is an important issue, and it is necessary to determine the mechanisms of viral dissemination in order to contain future epidemics. Based on phylogenetic inferences, sequence analysis and structure–function relationships of coronavirus proteins, informed by the knowledge currently available on the virus, we discuss the different scenarios on the origin—natural or synthetic—of the virus. The data currently available are not sufficient to firmly assert whether SARS-CoV2 results from a zoonotic emergence or from an accidental escape of a laboratory strain. This question needs to be solved because it has important consequences on the risk/benefit balance of our interactions with ecosystems, on intensive breeding of wild and domestic animals, on some laboratory practices and on scientific policy and biosafety regulations. Regardless of COVID-19 origin, studying the evolution of the molecular mechanisms involved in the emergence of pandemic viruses is essential to develop therapeutic and vaccine strategies and to prevent future zoonoses. This article is a translation and update of a French article published in Médecine/Sciences, August/September 2020 (10.1051/medsci/2020123).

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Section: An Evolutionary History By Fragmentsmentioning

confidence: 99%

Tracing the origins of SARS-COV-2 in coronavirus phylogenies: a review

et al. 2021

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“…The length of CoV genomes is about 30,000 nucleotides, which is exceptionally long for an RNA virus (by comparison, the length of AIDS and Ebola virus genomes are about 10,000 and 19,000 nucleotides, respectively). CoVs are able to maintain such a long genome thanks to a replication error correction system unique in the world of RNA viruses, that ensures a proofreading mechanism limiting the mutation rate (Eckerle et al 2010;Ferron et al 2018;Casane, Policarpo, et Laurenti 2019). The first two-thirds of the genome corresponds to a single gene, ORF1ab, coding for a polyprotein precursor, which is then cleaved into 16 proteins forming the replication/transcription complex.…”

Section: An Evolutionary History By Fragmentsmentioning

confidence: 99%

Retrouver les origines du SARS-CoV-2 dans les phylogénies de coronavirus

et al. 2020

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Le SARS-CoV-2 est un nouveau coronavirus (CoV) humain. Il a émergé en Chine fin 2019 et est responsable de la pandémie mondiale de Covid-19 qui a causé plus de 540 000 décès en six mois. La compréhension de l’origine de ce virus est une question importante et il est nécessaire de déterminer les mécanismes de sa dissémination afin de pouvoir se prémunir de nouvelles épidémies. En nous fondant sur des inférences phylogénétiques, l’analyse des séquences et les relations structure-fonction des protéines de coronavirus, éclairées par les connaissances actuellement disponibles, nous discutons les différents scénarios évoqués pour rendre compte de l’origine - naturelle ou synthétique - du virus.

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The Impact of Social and Behavioral Factors on Reproducibility in Terrestrial Vertebrate Models

Whittaker

Hickman

2019

ILAR Journal

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The use of animal models remains critical in preclinical and translational research. The reliability of the animal models and aspects of their validity is likely key to effective translation of findings to medicine. However, despite considerable uniformity in animal models brought about by control of genetics, there remain a number of social as well as innate and acquired behavioral characteristics of laboratory animals that may impact on research outcomes. These include the effects of strain and genetics, age and development, sex, personality and affective states, and social factors largely brought about by housing and husbandry. In addition, aspects of the testing environment may also influence research findings. A number of considerations resulting from the animals’ innate and acquired behavioral characteristics as well as their social structures are described. Suggestions for minimizing the impact of these factors on research are provided.

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Pourquoi le taux de mutation n’est-il jamais égal à zéro ?

Cited by 3 publications

References 28 publications

Tracing the origins of SARS-COV-2 in coronavirus phylogenies: a review

Tracing the origins of SARS-COV-2 in coronavirus phylogenies: a review

Retrouver les origines du SARS-CoV-2 dans les phylogénies de coronavirus

The Impact of Social and Behavioral Factors on Reproducibility in Terrestrial Vertebrate Models

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