Combining qualitative-quantitative approaches, we examined the reasons behind household movements into and out of poverty across Kenya, and how they differ by livelihood zones. Among the 4,773 households studied, 42% were poor 15 years ago and 50% are poor at the present time. Over the same period, 12% of the households escaped poverty, while another 20% fell into poverty. While some national trends were evident-such as the role of health problems in driving people into poverty and the importance of off-farm income in getting them out-many reasons differ across livelihood zones, thus this paper paper provides an example of how regionally differentiated anti-poverty policies can be investigated and designed.