Povidone-iodine solution as SARS-CoV-2 prophylaxis for procedures of the upper aerodigestive tract a theoretical framework

Abstract

Background The COVID-19 pandemic has raised concerns of inadvertent SARS-CoV-2 transmission to healthcare workers during routine procedures of the aerodigestive tract in asymptomatic COVID-19 patients. Current efforts to mitigate this risk focus on Personal Protective Equipment, including high-efficiency filtration as well as other measures. Because the reservoir for SARS-CoV-2 shedding is in the nasopharynx and nasal and oral cavities, the application of viricidal agents to these surfaces may reduce virus burden. Numerous studies have confirmed that povidone-iodine inactivates many common respiratory viruses, including SARS-CoV-1. Povidone-iodine also has good profile for mucosal tolerance. Thus, we propose a prophylactic treatment protocol for the application of topical povidone-iodine to the upper aerodigestive tract. Conclusion Such an approach represents a low-cost, low-morbidity measure that may reduce the risks associated with aerosol-generating procedures performed commonly in otorhinolaryngology operating rooms. Graphical abstract

Beneficial effects of a mouthwash containing an antiviral phthalocyanine derivative on the length of hospital stay for COVID-19

“…This result is probably due to mechanical hygiene of the oral and oropharynx cavities. There is in fact evidence of the effectiveness of the gargle/rinse protocol since local action is associated the regions that are intimately associated with the development of COVID-19 and play an important role in the defense of the host [7,10,29]. In this sense, mechanical hygiene reduces the super cial viral load of the oropharynx and oral mucosa and could prevent upper respiratory tract infections [30].…”

“…The virus enters the cell through the connection between the virus spike and the ACE2 receptor, which can be abundantly found in the salivary glands. Therefore, some recommendations have suggested the importance of controlling and reducing the viral load in the oral and oropharynx cavity by using an antiviral mouthwash [8,9,10,11,13,14,33].…”

“…It is clear that washing hands, wearing masks, and social distancing are effective measures to ght the pandemic [6,7]. In addition, considering that COVID-19 contagion, evolution and dissemination have strong associations with the mouth [8,9], gargling with antiseptic mouthwashes has been suggested as an extra preventive measure against COVID-19 [7,8,10,11,12,13,14,15,16,17]. However, in the cases of diseases, such as in uenza, which are caused by SARS-type viruses, virucidal activity is essential for such measures to be effective [8].…”

Povidone Iodine (PVP-I) Oro-Nasal Spray: An Effective Shield for COVID-19 Protection for Health Care Worker (HCW), for all

“…In lots of articles of scholars from different part of the world, use of PVP-I for intranasal and /or oral application is proposed or recommended, for COVID-19 prevention and for reduction of transmissibility of COVID-19 [ 4 , 5 , 6 , 7 , 8 ]. Several articles of different doctors and scientists recommended for a clinical trial on intranasal or intraoral application of PVP-I.…”

Beneficial effects of a mouthwash containing an antiviral phthalocyanine derivative on the length of hospital stay for COVID-19: Randomised trial

“…It is clear that washing hands, wearing masks, and social distancing are effective measures to ght the pandemic [6,7]. In addition, considering that COVID-19 contagion, evolution and dissemination have strong associations with the mouth [8,9], gargling with antiseptic mouthwashes has been suggested as an extra preventive measure against COVID-19 [7,8,10,11,12,13,14,15,16,17]. However, in the cases of diseases, such as in uenza, which are caused by SARS-type viruses, virucidal activity is essential for such measures to be effective [8].…”