Powder flow analysis: A simple method to indicate the ideal amount of lactose fines in dry powder inhaler formulations

Hertel, Mats; Schwarz, Eugen; Kobler, Mirjam; Hauptstein, Sabine; Steckel, Hartwig; Scherließ, Regina

doi:10.1016/j.ijpharm.2017.10.052

Cited by 52 publications

(8 citation statements)

References 16 publications

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“…It has also been confirmed by Hertel et al through studies on dry powder inhaler formulations that for lactose a high fines content reduces the permeability value at a given applied normal pressure [17]. The measured values of specific energy and pressure drop at maximum normal stress of 15 kPa are presented in Table 3.…”

Section: Flow Propertiessupporting

confidence: 62%

An experimental study of die filling of pharmaceutical powders using a rotary die filling system

Zakhvatayeva

Zhong

Makroo

et al. 2018

International Journal of Pharmaceutics

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Section: Flow Propertiessupporting

confidence: 62%

An experimental study of die filling of pharmaceutical powders using a rotary die filling system

Zakhvatayeva

Zhong

Makroo

et al. 2018

International Journal of Pharmaceutics

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“…This can be explained by the deep voids and clefts on the surface of Pearl300 revealed during the wet-sieving process. It is proposed that the latter were filled up with 'Preblend' during the blending process and allowed BDP to be more efficiently detached from the wet-sieved D-mannitol carrier surface (49). In contrast, the comparably smaller amount of MgSt was not enough to cause this effect.…”

Section: Impact Of Particle Engineering and Addition Of Ternary Agents On Drug De-attachmentmentioning

confidence: 99%

Spray-Congealing and Wet-Sieving as Alternative Processes for Engineering of Inhalation Carrier Particles: Comparison of Surface Properties, Blending and In Vitro Performance

et al. 2021

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Purpose Traditionally, α-lactose monohydrate is the carrier of choice in dry powder inhaler (DPI) formulations. Nonetheless, other sugars, such as D-mannitol, have emerged as potential alternatives. Herein, we explored different particle engineering processes to produce D-mannitol carriers for inhaled delivery. Methods Wet-sieving and spray-congealing were employed as innovative techniques to evaluate the impact of engineering on the particle properties of D-mannitol. To that end, the resulting powders were characterized concerning their solid-state, micromeritics and flowability. Afterwards, the engineered carrier particles were blended with inhalable size beclomethasone dipropionate to form low dose (1 wt%) DPI formulations. The in vitro aerosolization performance was evaluated using the NEXThaler®, a reservoir multi-dose device. Results Wet-sieving generated D-mannitol particles with a narrow particle size distribution and spray-congealing free-flowing spherical particles. The more uniform pumice particles with deep voids and clefts of wet-sieved D-mannitol (Pearl300_WS) were beneficial to drug aerosolization, only when used in combination with a ternary agent (10 wt% of ‘Preblend’). When compared to the starting material, the spray-congealed D-mannitol has shown to be promising in terms of the relative increase of the fine particle fraction of the drug (around 100%), when used without the addition of ternary agents. Conclusions The wet-sieving process and the related aerosolization performance are strongly dependent on the topography and structure of the starting material. Spray-congealing, has shown to be a potential process for generating smooth spherical particles of D-mannitol that enhance the in vitro aerosolization performance in binary blends of the carrier with a low drug dose.

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“…It was applied to evaluate the powder flowability based on the total energy input which is related to the shear stress developed on the rheometer impeller blade. This construction is widely used to determine flow properties of industrial powders [17,18], pharmaceutical solid dosage forms [19,20] and also lignite [21]. New approach to determine powder flow is Anton Paar two cells powder rheometer with powder shear cell and powder flow cell [22].…”

Section: Rheology In Dynamic Conditionsmentioning

confidence: 99%

Studies on Moisture Effects on Powder Flow and Mechanochemical Improvement of Powder Flowability

Opaliński¹,

Chutkowski²,

Mateusz³

et al. 2021

Adv. Sci. Technol. Res. J.

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Recent findings on some unsolved powder rheology problems and new challenges regarding mechanochemical powder processing and flow modelling are presented. There is remarkable difference in rheology when processing moist powders in static or dynamic conditions. Despite of regular trends of shear stress changes with humidity found in the both cases, some exceptions revealed the significant impact of particles size and their hygroscopic nature as example. Mechanochemical methods of high-energy interactive mixing of highly cohesive powders doped with nano-sized solid admixture enabled their flowability to be improved considerably. Using statistical approach, more general routine is proposed that allow the optimal mixing parameters to be reliably predicted with limited number of experiments needed. Ability to flow of some hygroscopic powders was examined with DEM method and extreme sensitivity of model output to input particle properties was found. The common DEM routine towards powder flow prediction is therefore suggested to be replaced with approach featuring in using DEM method to identify some unknown powder flow factors.

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Powder flow analysis: A simple method to indicate the ideal amount of lactose fines in dry powder inhaler formulations

Cited by 52 publications

References 16 publications

An experimental study of die filling of pharmaceutical powders using a rotary die filling system

An experimental study of die filling of pharmaceutical powders using a rotary die filling system

Spray-Congealing and Wet-Sieving as Alternative Processes for Engineering of Inhalation Carrier Particles: Comparison of Surface Properties, Blending and In Vitro Performance

Studies on Moisture Effects on Powder Flow and Mechanochemical Improvement of Powder Flowability

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