This study presents a 3D transient Computational Fluid Dynamics (CFD) model that simulates hot metal desulfurization (HMD) using calcium carbide and calcium oxide in an experimental‐scale ladle with a 70 kg capacity. The model takes into account the efficiency of reagent particles penetrating carrier gas bubbles and is validated through experimental work, with an average difference of 7.06%. The research discusses the effects of varying reagent particle sizes, hot metal temperatures, gas flow rates, and ladle design on desulfurization rates. Results indicate that when particle diameter decreases from 30 um to 20.9 um and 11.8 um, desulfurization rates rise from 50.92% to 66.02% and 89.99%, respectively. Regarding hot metal temperature, a 100‐degree range results in a final desulfurization rate difference of less than 3%. The study also reveals that increasing the carrier gas flow rate from 13 SLPM to 15 SLPM reduces the removal rate by 6.10%. As particle gas flow rate increase from 200 g/min to 300 g/min, the removal rate increase by 9.02%. In the lance arrangement analysis, the duo lance system demonstrates nearly identical desulfurization performance to the single‐center lance system, which outperforms the off‐center lance system.This article is protected by copyright. All rights reserved.