Powder Particles and Technologies for Medicine Delivery to the Respiratory System: Challenges and Opportunities

Sosnowski, Tomasz R.

doi:10.14356/kona.2018020

Cited by 18 publications

(2 citation statements)

References 92 publications

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“…The most important point is that dry powders can be aerosolized easily with a low air-flow rate and low pressure that are in the normal range for inhalation. As inhalable dry powders often display coagulating properties caused by cohesiveness and adhesiveness ( 27 , 28 ), the development of formulations producing fine and dispersed powders is necessary ( 29 ).…”

Section: Discussionmentioning

confidence: 99%

Uniformity and Efficacy of Dry Powders Delivered to the Lungs of a Mycobacterial-Surrogate Rat Model of Tuberculosis

et al. 2021

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Purpose Pulmonary administration of dry drug powder is a considered promising strategy in the treatment of various lung diseases such as tuberculosis and is more effective than systemic medication. However, in the pre-clinical study phase, there is a lack of devices for effective delivery of dry powders to the lungs of small rodents. In this study, an administration device which utilizes Venturi effect to deliver dry powders to the lungs homogeneously was developed. Methods A Venturi-effect administration device which synchronizes with breathes by use of a ventilator and aerosolizes the dry powders was created. Pulmonary distribution of inhalable dry powders prepared by spray-drying poly(lactic-co-glycolic) acid and an antituberculosis agent rifampicin and anti-tuberculosis effect of the powders on mycobacteria infected rats by administration with the Venturi-effect administration device and a conventional insufflation device were evaluated. Results Homogeneous distribution of the dry powders in the lung was achieved by the Venturi-effect administration device due to efficient and recurring aerosolization of loaded dry powders while synchronizing with breathes. Amount of rifampicin delivered to the lungs by the Venturi-effect administration device was three times higher than that by a conventional insufflation device, demonstrating three times greater antimycobacterial activity. Conclusions The Venturi-effect administration device aerosolized inhalable antituberculosis dry powders efficiently, achieved uniform pulmonary distribution, and aided the dry powders to exert antituberculosis activity on lung-residing mycobacteria.

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Section: Discussionmentioning

confidence: 99%

Uniformity and Efficacy of Dry Powders Delivered to the Lungs of a Mycobacterial-Surrogate Rat Model of Tuberculosis

et al. 2021

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“…Based on the size distribution of aerosol particles, two essential factors were evaluated: the volumetric median diameter (VMD = D V 50) and the percentage of particle fraction smaller than 5 µm (fine particle fraction, FPF). Both of the parameters are the essential quality indicators of aerosol that is produced by the inhalation drug delivery system [ 42 , 43 ]. In addition, the percentage of particles smaller than 10 µm (inhalable particles) and value of span were determined.…”

Section: Methodsmentioning

confidence: 99%

Bioactive Betulin and PEG Based Polyanhydrides for Use in Drug Delivery Systems

Niewolik

Bednarczyk–Cwynar

Ruszkowski

et al. 2021

IJMS

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In the course of this study, a series of novel, biodegradable polyanhydrides based on betulin disuccinate and dicarboxylic derivatives of poly(ethylene glycol) were prepared by two-step polycondensation. These copolymers can be used as carriers in drug delivery systems, in the form of microspheres. Betulin and its derivatives exhibit a broad spectrum of biological activity, including cytotoxic activity, which makes them promising substances for use as therapeutic agents. Microspheres that were prepared from betulin based polyanhydrides show promising properties for use in application in drug delivery systems, including inhalation systems. The obtained copolymers release the active substance—betulin disuccinate—as a result of hydrolysis under physiological conditions. The use of a poly(ethylene glycol) derivative as a co-monomer increases the solubility and bioavailability of the obtained compounds. Microspheres with diameters in the range of 0.5–25 µm were prepared by emulsion solvent evaporation method and their physicochemical and aerodynamic properties were analyzed. The morphological characteristics of the microspheres depended on the presence of poly(ethylene glycol) (PEG) segment within the structure of polyanhydrides. The porosity of the particles depended on the amount and molecular weight of the PEG used and also on the speed of homogenization. The most porous particles were obtained from polyanhydrides containing 20% wt. of PEG 600 by using a homogenization speed of 18,000 rpm.

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Cascade Impactor Study of Aerosolization Process During Passive Dry Powder Inhaler Performance Under Unsteady Versus Steady Flow Conditions

Dorosz

Cánovas

Moskal

2020

Practical Aspects of Chemical Engineering

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Powder Particles and Technologies for Medicine Delivery to the Respiratory System: Challenges and Opportunities

Cited by 18 publications

References 92 publications

Uniformity and Efficacy of Dry Powders Delivered to the Lungs of a Mycobacterial-Surrogate Rat Model of Tuberculosis

Uniformity and Efficacy of Dry Powders Delivered to the Lungs of a Mycobacterial-Surrogate Rat Model of Tuberculosis

Bioactive Betulin and PEG Based Polyanhydrides for Use in Drug Delivery Systems

Cascade Impactor Study of Aerosolization Process During Passive Dry Powder Inhaler Performance Under Unsteady Versus Steady Flow Conditions

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