Multimedia comprises of audio, text, image and video. Use of multimedia is increasing because of improvements in hardware, algorithms and networking. Confidentiality of data is the primary concern due to applications in commerce, telemedicine, Internet television, video telephony, multiparty P2P conferences, video on demand and military. Multimedia files are data intensive thus, they need more computational power and consume more memory as compared to ordinary text data. Comparative analysis of vulnerabilities and counter measures are made. In this paper, possibilities of securing multimedia data using various encryption methods and modes are analyzed and compared on the basis of their execution speed, hardware implementation and various attacks. It is found that public key cryptosystems are comparatively slow and they get more vulnerability. Comparative analysis shows that confusion and diffusion are used in many faster cryptosystems to measure the security level. Moreover, hardware implementation (ASIC and FPGA) provides better security than software implementations. ASIC and FPGA implementations had high variation in throughput irrespective of the cryptosystem.