The purpose of this study is to find the psychological determinants of the mental stress of students while they are pursuing a professional degree. Using a sample of college-going students, an effort is made to peep into such students' mental stress-determining factors. Three major determinants came into focus, namely depression and tearfulness, feeling loved, and personal life, which was confirmed using confirmatory factor analysis. Such mental stress determinants, if addressed, could lead to progress in the mental health of our students and the happiness of the society of which they are part. Spiritual and educational strategies can be used to understand better symptoms related to mental stress and treatments thereof making them industry-ready.