Power and Sample Size for Health Researchers: uma ferramenta para cálculo de tamanho amostral e poder do teste voltado a pesquisadores da área da saúde

Borges, Rogério Boff; Mancuso, Aline Castello Branco; Camey, Suzi Alves; Leotti, Vanessa Bielefeldt; Hirakata, Vânia Naomi; Azambuja, Guilherme Serpa; Castro, Stela Maris de Jezus

doi:10.22491/2357-9730.109542

Cited by 41 publications

(35 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Considering the power of 80% and a significance level of 5% (92)(93)(94), and a moderate correlation of r = 0.40 to 0.6 (95), a sample of 30 individuals would be able to detect differences in the emotional eating variable (TFEQ-EE and DERS) in accordance with previous studies that considered a correlation between emotional eating and emotion regulation of 0.3 clinically relevant (96,97).…”

Section: Discussionsupporting

confidence: 62%

Emotional eating in women with generalized anxiety disorder

Fonseca¹,

Costa²,

Gosmann³

et al. 2023

Trends Psychiatry Psychother

View full text Add to dashboard Cite

Introduction: Individuals diagnosed with Generalized Anxiety Disorder (GAD) search for pleasurable foods to avoid their negative emotional experiences. An ineffective regulation of negative emotions may be a risk factor for emotional eating, leading to suffering, dysfunctional behaviors and weight gain. The aim of this study is to understand the relationship between emotional dysregulation and emotional eating, investigating potential mediators as the intensity of the worry, avoidance of internal experiences, mindfulness and self-compassion in female anxious patients. Methods: Participants from a randomized clinical trial diagnosed with GAD answered the instruments at baseline: Difficulties in Emotion Regulation Scale (DERS), Three Factor Eating Questionnaire (TFEQ-R21), Penn State Worry Questionnaire (PSWQ), Action and Acceptance Questionnaire (AAQ), Five Facet Mindfulness Questionnaire (FFMQ), and Self-Compassion Scale (SCS) in this cross-sectional study. We estimated Pearson correlation coefficients and performed mediation analyses. Results: We evaluated 51 individuals and 34 female participants completed all the questionnaires. Our data showed that emotional eating was positively correlated with emotional dysregulation (r=0.593; p<0.001), worry trait (r=0.402; p=0.018), and avoidance of internal experiences (r=0.565; p<0.001), whereas it was negatively correlated with self-compassion (r=-0.590; p<0.001) and mindful state (r=-0.383; p=0.026).Moreover, we demonstrated that self-compassion mediates the relationship between emotional dysregulation and emotional eating (ab product estimate = 0.043, 95% CI [0.003 to 0.084]). Conclusion: Our findings could add to the literature by identifying psychological factors that could mediate the association between emotional dysregulation and emotional eating, allowing more effective eating behavior intervention targets in patients with GAD.

show abstract

Section: Discussionsupporting

confidence: 62%

Emotional eating in women with generalized anxiety disorder

Fonseca¹,

Costa²,

Gosmann³

et al. 2023

Trends Psychiatry Psychother

View full text Add to dashboard Cite

show abstract

“…The sample size was calculated to test whether the Spearman correlation coefficient between FVC and FMR was greater than zero using the PSS Health tool, online version 10 . Considering a 5% significance level, 80% power, and an expected correlation of 0.5, the total sample size of 23 subjects was reached.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary function and respiratory muscle strength at hospital discharge in COVID-19 patients after Intensive Care Unit admission

2022

View full text Add to dashboard Cite

This study describes the pulmonary function and respiratory muscle strength (RMS) at hospital discharge of severe COVID-19 patients, correlating them with peripheral muscle strength, duration of mechanical ventilation (MV), length of hospital stay, and use of medication. A cross-sectional study was conducted with COVID-19 patients admitted to the Intensive Care Unit. Assessment at hospital discharge included the following variables: RMS, pulmonary function, and peripheral muscle strength (Medical Research Council score [MRC] and handgrip dynamometry). A total of 25 patients with mean age of 48.7±12.3 years were assessed. Out of these, 72% presented restrictive ventilatory disorder, in addition to reduced RMS (maximum inspiratory pressure [MIP] of 74% and maximum expiratory pressure [MEP] of 78% of the predicted value). RMS (MIP and MEP, respectively) correlated negatively with duration of MV (r=−0.599, p=0.002; r=−0.523, p=0.007) and length of hospital stay (r=−0.542, p=0.005; r=−0.502, p=0.01); and positively with FVC (r=0.825, p=0.000; r=0.778, p=0.000), FEV1 (r=0.821, p=0.000; r=0.801, p=0.000), PEF (r=0.775, p=0.000; r=0.775, p=0.000), and handgrip strength (r=0.656, p=0.000; r=0.589, p=0.002). At hospital discharge, severe COVID-19 patients presented: reduced RMS; changes in lung function; negative correlation between RMS and duration of invasive mechanical ventilation (IMV), and length of hospital stay; and a positive correlation with lung function and hand grip strength.

show abstract

“…To calculate sample size using conversion rate as the primary outcome, the control group conversion rate was considered the percentage of PANs who completed at least one follow‐up visit and converted to ataxia during the whole follow‐up period. The “Power and Sample Size for Health Researchers” 25 tool online version was used, and sample size calculation was done for a 2‐year follow‐up CT, with two balanced arms (1:1), considering a 5% level of significance and for both 80% and 90% power. The sample size needed to decrease in 50% the progression of some continuous outcomes for PAN individuals was also calculated, considering again a 2‐year follow‐up CT with annual visits, two balanced arms (1:1), 5% level of significance, and 80% power.…”

Section: Methodsmentioning

confidence: 99%

Progression of Clinical and Eye Movement Markers in Preataxic Carriers of Machado‐Joseph Disease

et al. 2022

View full text Add to dashboard Cite

Background Little is known about preclinical stages of Machado‐Joseph disease, a polyglutamine disorder characterized by progressive adult‐onset ataxia. Objective We aimed to describe the longitudinal progression of clinical and oculomotor variables in the preataxic phase of disease. Methods Carriers and noncarriers were assessed at three visits. Preataxic carriers (Scale for Assessment and Rating of Ataxia score < 3) expected to start ataxia in ≤4 years were considered near onset (PAN). Progressions of ataxic and preataxic carriers, considering status at the end of the study, were described according to the start (or its prediction) of gait ataxia (TimeToAfterOnset) and according to the study time. Results A total of 35 ataxics, 38 preataxics, and 22 noncarriers were included. The “TimeToAfterOnset” timeline showed that Neurological Examination Scale for Spinocerebellar Ataxias (NESSCA; effect size, 0.09), Inventory of Non‐Ataxia Symptoms (INAS0.07), and the vestibulo‐ocular reflex gain (0.12) progressed in preataxic carriers, and that most slopes accelerate in PAN, turning similar to those of ataxics. In the study time, NESSCA (1.36) and vertical pursuit gain (1.17) significantly worsened in PAN, and 6 of 11 PANs converted to ataxia. For a clinical trial with 80% power and 2‐year duration, 57 PANs are needed in each study arm to detect a 50% reduction in the conversion rate. Conclusions NESSCA, INAS, vestibulo‐ocular reflex, and vertical pursuit gains significantly worsened in the preataxic phase. The “TimeToAfterOnset” timeline unveiled that slopes of most variables are small in preataxics but increase and reach the ataxic slopes from 4 years before the onset of ataxia. For future trials in preataxic carriers, we recommend recruiting PANs and using the conversion rate as the primary outcome. © 2022 International Parkinson and Movement Disorder Society.

show abstract

Power and Sample Size for Health Researchers: uma ferramenta para cálculo de tamanho amostral e poder do teste voltado a pesquisadores da área da saúde

Cited by 41 publications

References 0 publications

Emotional eating in women with generalized anxiety disorder

Emotional eating in women with generalized anxiety disorder

Pulmonary function and respiratory muscle strength at hospital discharge in COVID-19 patients after Intensive Care Unit admission

Progression of Clinical and Eye Movement Markers in Preataxic Carriers of Machado‐Joseph Disease

Contact Info

Product

Resources

About