Abstract. Recently the creation matrix, intimately related to the Pascal matrix and its generalizations, has been used to develop matrix representations of special polynomials, in particular Appell polynomials. In this paper we describe a matrix approach to polynomials in several hypercomplex variables based on special block matrices whose structures simulate the creation matrix and the Pascal matrix. We apply the approach to hypercomplex Laguerre polynomials, although it can be used for other Appell sequences, too.