Power spectral analysis of the electrocardiogram in diabetic children

Rollins, Michael D.; Jenkins, John; Dj, Carson; McClure, B G; Mitchell, R. H.; Imam, Sardar Zakariya

doi:10.1007/bf02342443

Cited by 57 publications

(45 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…13 A causal linkage between altered ANS activity and obesity cannot be confirmed; however, our findings are partly confirmatory of the above theory, as well as our previous investigation 15 which shows that reduced SNS and PNS activities exist in sedentary obese children. Even during childhood, lower levels of PNS activity are related to cardiac autonomic neuropathy in diabetic patients with poor glycemic control, 34 duration of diabetes, 35 and high blood pressure. 36 Therefore, reduced ANS activity appearing in our healthy obese children might be a possible early sign which might affect the future cardiovascular and metabolic related disorders.…”

Section: Discussionmentioning

confidence: 99%

Effect of physical activity on autonomic nervous system function in lean and obese children

2003

View full text Add to dashboard Cite

OBJECTIVE:The autonomic nervous system (ANS) is a key factor in the regulation of energy balance and body fat storage; however, to what extent the physical activity during the childhood years contributes to variations in ANS function is still unclear. The present study was designed to investigate the ANS activity in lean and obese children, focusing on the differences in physical activity levels. SUBJECTS: This study was performed on 1080 school children initially recruited to the present study. In all, 24 physically active and 24 inactive obese children (Z120% of the standard body weight) were chosen as samples. Then, 24 lean-active and 24 lean-inactive children, who were matched individually in age, gender, height, and the amount of sports activity, were carefully selected from the remaining children. MEASUREMENTS: Physical activity was classified as the frequency of participation in after-school sports activities (active; Z3 times per week, inactive; nothing). The ANS activities were measured during the resting condition by means of heart rate (HR) variability power spectral analysis, which enables us to identify separate frequency components, that is, low frequency (LF; 0.03-0.15 Hz), reflecting mixed sympathetic (SNS) and parasympathetic nervous system (PNS) activity, high frequency (HF; 0.15-0.5 Hz), mainly associated with PNS activity, and total power (TP; 0.03-0.5 Hz), evaluating the overall ANS activity. The spectral powers were log transformed for statistical testing. RESULTS:The lean-active group demonstrated lower resting HR as well as significantly higher TP, LF, and HF powers compared to the remaining groups. In contrast, the obese-inactive group showed significantly lower TP (Po0.05 vs the remaining groups), LF (Po0.05 vs the lean groups), and HF power (Po0.05 vs the lean groups), respectively. The obese-active and lean-inactive groups were nearly identical in all spectral parameters. The correlation analysis revealed that TP among 48 inactive children was significantly and negatively associated with the percentage of body fat (r ¼ À0.53, Po0.001); however, such correlation among 48 active children was modest (r ¼ À0.33, P ¼ 0.02). CONCLUSION: Our data suggest that obese children possess reduced sympathetic as well as parasympathetic nervous activities as compared to lean children who have similar physical activity levels. Such autonomic reduction, associated with the amount of body fat in inactive state, might be an etiological factor of onset or development of childhood obesity. On the other hand, regular physical activities could contribute to enhance the overall ANS activity in both lean and obese children. These findings further imply that regular physical activity might be effective in preventing and treating obesity beginning in the childhood.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of physical activity on autonomic nervous system function in lean and obese children

2003

View full text Add to dashboard Cite

show abstract

“…27 Shiono et al 28 studied children and adolescents aged 7 to 20 years with poor glycemic control (hemoglobin A 1c Ն10%) with signal-averaged ECG; the authors found a prolonged filtered QRS duration and a significantly low root mean square voltage, demonstrating subclinical cardiac impairment.…”

Section: Fetal and Childhood Ecg Signs In Diabetes Mellitusmentioning

confidence: 99%

The ECG in Diabetes Mellitus

Stern

2009

Circulation

View full text Add to dashboard Cite

“…Since signs of CAN can be detected in young IDDM patients [2,3], disturbed autonomic function is unlikely to be the sole determinant in the genesis of ventricular arrhythmias. Rather, CAN appears to be a contributing mechanism increasing the propensity for fatal ventricular arrhythmias in the presence of an arrhythmic substrate.…”

Section: For Debatesmentioning

confidence: 99%

“…generally occur only in patients with diabetes mellitus of long duration, it has become evident that subclinical DAN, mainly in the form of cardiac autonomic neuropathy (CAN), evolves early in the course of diabetes [1][2][3], and in the absence of other microvascular complications [3][4][5]. The hallmark and earliest indicator of CAN is a reduced heart rate variability (HRV) [6].…”

mentioning

confidence: 99%