Power Spectral Density Analysis of Electrocorticogram Recordings during Cerebral Hypothermia in Neonatal Seizures

Abstract

Background: Neonatal seizures (NS) are the most common form of neurological dysfunction observed in newborns. Purpose: The purpose of this study in newborn piglets was to determine the effect of cerebral hypothermia (CH) on neural activity during pharmacologically induced NS. We hypothesized that the neuroprotective effects of CH would preserve higher frequencies observed in electrocorticogram (ECoG) recordings. Methods: Power spectral density was employed to determine the levels of brain activity in ECoGs to quantitatively assess the power of each frequency observed in neurological brain states of delta, theta, alpha, and beta-gamma frequencies. Result: The most significant reduction of power occurs in the lower frequency band of delta-theta-alpha of CH cohorts, while t score probabilities imply that high-frequency brain activity in the beta-gamma range is preserved in the CH population. Conclusion: While the overall power density decreases over time in both groups, the decrease is to a lesser degree in the CH population.

Effects of inhibitory and excitatory neurons on the dynamics and control of avalanching neural networks

“…The model described in Sec. II accurately recreates the avalanche strength distribution, the avalanche duration distribution, and the power spectrum distribution observed in rat and human cortices [6,18]. In order to also generate experimentally detected waiting time distributions, the model must be extended.…”

“…Electroencephalography and electrocorticography both measure the action potentials of neurons firing in living brains through the placement of electrodes either outside (electroencephalography) or inside (electrocorticography) the skull. The time series measurement of electrical activity can be decomposed into their power spectral density and has been suggested as a means to diagnose epilepsy [7,18]. Healthy non-epileptic brains have a PSD exponent in the range of (−1.5, −0.8) [12], while brains undergoing epileptic events have been recorded with PSD exponents in the range of (−2.2, −1.8) [7,12].…”

“…Several different parameters of neural avalanches can be studied through statistical analysis, and have been shown to be important to the proper operation of biological neural networks [6][7][8]18]. These observables are the avalanche strength, the avalanche duration, and the power spectral density of neuron activity.…”

Spectral Power Density analysis of the resting-state as a marker of the central effects of opioid use in fibromyalgia

“…Different levels of consciousness and cognitive activity can be associated with specific frequency bands. In this sense, broadly speaking, beta waves are associated with active and effortful cognitive activity, alpha with calmness and relaxed state, theta with deep relaxation and day dreaming, and delta with sleep, easily evident in the stages of sleep 23 .…”

A Hybrid System for Distinguishing between Brain Death and Coma Using Diverse EEG Features

“…In Alzheimer’s patients the alpha EEG power is significantly decreased but the theta power is increased [12]. Myers et al have discovered that the high-frequency brain activity in the beta-gamma range is preserved in the Cerebral Hypothermia population [13]. In addition, it consists of non-parameter and parameter-based methods [14].…”