Powerful antioxidative agents based on garcinoic acid from Garcinia kola

Terashima, Kenji; Takaya, Yoshiaki; Niwa, Masayuki

doi:10.1016/s0968-0896(01)00428-x

Cited by 102 publications

(71 citation statements)

References 4 publications

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“…The greater the severity of insults, the more rapid the progression of neuronal injury. 3-Niropropionic acid destroys neurons both directly at the level of the cell body and at the axonal domain by showing retrograde degeneration due to damage of both their afferents and their parent axons [4,[14][15][16][17][18] . The mechanism of striatal cell death after systemic administration of 3-Nitropropionic acid is not well understood, although several factors may contribute to selective vulnerability of medium-sized spiny striatal neurons.…”

Section: Discussionmentioning

confidence: 99%

The microstructural effects of aqueous extract of Garcinia kola (Linn) on the hippocampus and cerebellum of malnourished mice

Ajayi¹,

Ofusori²,

Ojo³

et al. 2011

Asian Pacific Journal of Tropical Biomedicine

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Section: Discussionmentioning

confidence: 99%

The microstructural effects of aqueous extract of Garcinia kola (Linn) on the hippocampus and cerebellum of malnourished mice

Ajayi¹,

Ofusori²,

Ojo³

et al. 2011

Asian Pacific Journal of Tropical Biomedicine

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“…Other workers have investigated the effects of flavonoids of other plants and of synthetic flavonoids on some smooth muscle activity of experimental animals (Ogata et al, 1993;Belluco et al, 1993;Di Carlo et al, 1993). Biflavonoids from G. kola have anti-inflammatory properties (Braide, 1993), is a natural antioxidant (Olatunde et al 2002, Terashima et al, 2002Olatunde et al, 2002b;Farombi et al, 2007) and is hepatoprotective (Adaramoye and Adeyemi, 2006;Farombi et al, 2009;Adaramoye et al, 2008) Extracts from G. kola seeds have been reported to alter oestrous cycle, inhibit ovulation, induce teratogenicity (Akpantah et al, 2005), and to be non-toxic to erythrocytes even at high dose ranges (Esomonu et al, 2005). In the search for alternatives to synthetic hypoglycaemic agents, Adaramoye and Adeyemi (2006) reported antidiabetic and hypolipidaemic effects of fractions of Kolaviron, (a G. kola seed extract) in streptozotocin (STZ)-diabetic rats.…”

Section: Introductionmentioning

confidence: 99%

Antispasmodic and spasmolytic effects of methanolic extract from seeds of garcinia kola on isolated rat small intestine

Udia¹,

Braide²,

Owu³

2010

Nig. J. Phys Sci

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Summary:The antispasmodic and spasmolytic effects of methanolic extract of seeds of Garcinia kola Heckel were studied on smooth muscle preparations in vitro. The influence of the extract on rat duodenum, jejunum and ileum was investigated using acetylcholine and barium chloride as agonists. The extract exhibited dose-dependent antispasmodic effects on contractions induced by acetylcholine, and dose-dependent spasmolytic effects on spasms induced by cumulatively increased concentrations of acetylcholine and barium chloride. The graded log concentration-response curves for acetylcholine were non-parallel but shifted to the right in the presence of the extract. It is concluded that the Garcinia kola extract inhibits smooth muscle activity via other mechanisms but not involving neither cholinergic nor adrenergic receptor interaction.

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“…Theplant flavonoids have biological functions such as protection against allergies, inflammation, free radical, platelet aggregation, microbes, ulcers, hepatoxins, viruses and tumor [20,21]. Flavonoids are water soluble antioxidants and free radical scavengers which prevent oxidative cell damage, having strong anticancer activity which protect against the carcinogenesis [21].…”

Section: Resultsmentioning

confidence: 99%

Phytochemicals, antibacterial, antifungal and cytotoxicity of some selected medicinal plants from Bhandardara area, Maharashtra

2017

IJAPSA

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This attempt was assigned to evaluate the phytochemical constituents, antifungal, antibacterial and cytotoxicity of eleven medicinal plants from Bhandhara area. The phytochemicals such as steroids, anthraquinone, tannins, saponin, alkaloids, phlobatannin, glycosides, quinine and flavonoids were tested qualitatively. Antifungal, antibacterial and cytotoxicity was evaluated with the respective strains in laboratory condition. The total contents of flavonoids were examined quantitatively in eleven plant species and showed maximum (23%) contents from Terminalia chebula (Retz) followed by Vitex nigundo (L). The antibacterial, antifungal and cytotoxicity were conducted. The highest antibacterial potential was revealed from the extracts of Termanalia chebula (Retz) against E. coli, followed by Glycyrrhiza glabra (L) to Pseudomonas pudita. Antifungal activity of eleven plants was tested against the four fungal strains and showed that highest potentials in Termanalia chebula (Retz) while followed by Vitex nigundo (L) and Bacopa mannieri (L). The cytotoxicity was reported on chick embryo cell line against eleven species for their establishment and two species were showed high percent viability fromTerminalia chebula (Retz) (72.2%) followed by Acacia catechu (L.) (65.8%). The viability varies species to species. The phytochemicals are the indicatives of the plant species could be a possible source of obtaining new and effective source of herbal medicine.The antibacterial, antifungal potential activities are better source for further herbal medicine.

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Powerful antioxidative agents based on garcinoic acid from Garcinia kola

Cited by 102 publications

References 4 publications

The microstructural effects of aqueous extract of Garcinia kola (Linn) on the hippocampus and cerebellum of malnourished mice

The microstructural effects of aqueous extract of Garcinia kola (Linn) on the hippocampus and cerebellum of malnourished mice

Antispasmodic and spasmolytic effects of methanolic extract from seeds of garcinia kola on isolated rat small intestine

Phytochemicals, antibacterial, antifungal and cytotoxicity of some selected medicinal plants from Bhandardara area, Maharashtra

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