Powering tyrosol antioxidant capacity and osteogenic activity by biocatalytic polymerization

Antenucci, Stefano; Panzella, Lucia; Farina, H.; Ortenzi, Marco Aldo; Caneva, Enrico; Martinotti, Simona; Ranzato, Elia; Burlando, Bruno; d’Ischia, Marco; Napolitano, Alessandra; Verotta, Luisellá

doi:10.1039/c5ra23004g

Cited by 13 publications

(23 citation statements)

References 63 publications

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“…This can be explained by the oxidation followed by the precipitation of total phenols. A small increase in the color intensity was observed at a high concentration of hydrogen peroxide, which can be attributed by either to the deactivation of the enzyme due to the high concentration of hydrogen peroxide or to the resolubilization of the polymerized phenols [41].…”

Section: Resultsmentioning

confidence: 96%

Phenolics decontamination of olive mill wastewater using onion solid by-products homogenate

Reheem¹,

Yılmaz²,

Elhag³

2019

Desalination and Water Treatment

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a b s t r a c tThe aim of this article was to treat olive oil mill waste with onion peroxidase with regard to the removal of polyphenols and decolonization. Determination of the optimum conditions for the treatment of olive mill wastewater was another objective of this study. Results showed a pH optimum of around 2.65 and a concentration of H 2 O 2 of around 2.58 mM. Moreover, o-diphenols could be removed in a short period of time in comparison to the total phenols. The results showed that three hours were sufficient for 75% removal of o-diphenols. Dilution 1 over 20 of the olive mill wastewaters and the addition of some additives (NaCl and polyethylene glycol) in the treatment of olive mill wastewater (OMW) could enhance the efficiency of total phenol removal as well as, a decrease in the color intensity of the olive oil wastewater. In addition, high performance liquid chromatography (HPLC) analyzes were carried out on samples representing OMW before and after the treatment. Results showed that the degradation of some phenols was carried out with the use of onion peroxidase, as well as with the use of the optimal conditions regarding the pH and the concentration of hydrogen peroxide. It was concluded that onion peroxidase could catalyze the degradation of total phenols and o-diphenols and that such degradation could also influence the change in color and the antioxidant activity of the olive oil mill wastewater.

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Section: Resultsmentioning

confidence: 96%

Phenolics decontamination of olive mill wastewater using onion solid by-products homogenate

Reheem¹,

Yılmaz²,

Elhag³

2019

Desalination and Water Treatment

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“…Horseradish and soybean peroxidase were used for polymerization of m -cresol [ 76 ], cardanol [ 77 ] and guaiacol [ 78 ]. Other relevant examples of bioinspired phenolic polymers include poly(caffeic acid methyl ester) [ 79 ], poly(pyrogallic acid) [ 80 , 81 ] and polytyrosol [ 82 ] ( Figure 5 ).…”

Section: Main Sources Of Natural Phenol Polymersmentioning

confidence: 99%

“…Brown algae phlorotannins, such as triphlorethol A, eckol and dieckol, proved effective in enhancing the osteoblast differentiation as indicated by increased alkaline phosphatase activity along with raised levels of osteoblastogenesis indicators and intracellular calcification [ 177 ]. Similarly, polytyrosol, a mixture of oligomers from enzymatic tyrosol oxidation, stimulated alkaline phosphatase activity of osteosarcoma SaOS-2 cells at Day 7 also when loaded at 5% w / w into highly porous polylactic acid scaffolds featuring hierarchical structures, while tyrosol was completely inactive [ 82 ].…”

Section: Main Applications Of Phenol-based Polymers In Food and Hementioning

confidence: 99%

Natural Phenol Polymers: Recent Advances in Food and Health Applications

Panzella

Napolitano

2017

Antioxidants

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Natural phenol polymers are widely represented in nature and include a variety of classes including tannins and lignins as the most prominent. Largely consumed foods are rich sources of phenol polymers, notably black foods traditionally used in East Asia, but other non-edible, easily accessible sources, e.g., seaweeds and wood, have been considered with increasing interest together with waste materials from agro-based industries, primarily grape pomace and other byproducts of fruit and coffee processing. Not in all cases were the main structural components of these materials identified because of their highly heterogeneous nature. The great beneficial effects of natural phenol-based polymers on human health and their potential in improving the quality of food were largely explored, and this review critically addresses the most interesting and innovative reports in the field of nutrition and biomedicine that have appeared in the last five years. Several in vivo human and animal trials supported the proposed use of these materials as food supplements and for amelioration of the health and production of livestock. Biocompatible and stable functional polymers prepared by peroxidase-catalyzed polymerization of natural phenols, as well as natural phenol polymers were exploited as conventional and green plastic additives in smart packaging and food-spoilage prevention applications. The potential of natural phenol polymers in regenerative biomedicine as additives of biomaterials to promote growth and differentiation of osteoblasts is also discussed.

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“…여기서 salidroside는 여정실에서는 처음으로 분리되었다. 문헌에 보고된 바에 의하면 tyrosol은 아미노산인 타이로신으로부 터 카복실기가 제거되어 생성된 물질이며 지중해 식단을 구성하는 올리브 오일의 주요한 페놀 구성성분들중에 하 나로서 과거 수 십년 동안 항미생물, 항트롬빈, 항염증, 심 장보호 등과 같은 다양한 생리활성으로 주목을 받았다 (Gris et al 2011;Choe et al 2012;Vlachogianni et al 2015;Antenucci et al 2016). Phenylpropanoid glycoside 인 salidroside는 이전에 참돌꽃(Rhodiola sachalinensis), 산청목(Acer tegmentosum) 등으로부터 분리되었으며 (Kim et al 2004;Lee et al 2014), 항암, 항염증, 항저산소증, Means with the different letters at the same concentration are significantly different (P < 0.05) by Duncan's multiple range test.…”

Section: A-kunclassified

Antioxidant Activity of Fruits of Ligustrum japonicum

Seo¹,

Kim²

2017

Ocean and Polar Research

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: The objective of this study is to evaluate the antioxidant activity of the fruits of Ligustrum japonicum. The crude extract was successively fractionated into n-hexane, 85% aqueous methanol (85% aq.MeOH), n-butanol (n-BuOH), and water fractions by means of solvent polarity. The crude extract and its solvent fractions were evaluated for their antioxidant effect by four different assay systems: scavenging power on peroxynitrite and intralcellular ROS produced in HT-1080 cells; DNA oxidation inhibition; ferric reducing antioxidant power (FRAP). The n-BuOH fraction exhibiting potent antioxidant activity was further purified by C18 silica gel column chromatography and RP-HPLC to give tyrosol (1) and salidroside (2). The structure of isolated compounds was determined by extensive 2 D NMR experiments such as 1 H COSY, NOESY, HSQC and HMBC as well as by comparison with the published spectral data.

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Powering tyrosol antioxidant capacity and osteogenic activity by biocatalytic polymerization

Cited by 13 publications

References 63 publications

Phenolics decontamination of olive mill wastewater using onion solid by-products homogenate

Phenolics decontamination of olive mill wastewater using onion solid by-products homogenate

Natural Phenol Polymers: Recent Advances in Food and Health Applications

Antioxidant Activity of Fruits of Ligustrum japonicum

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