Cylinder deactivation has been recently demonstrated to have fuel savings and aftertreatment thermal management benefits at low to moderate loads compared to conventional operation in diesel engines. This study discusses dynamic cylinder activation as an effective variant to fixed diesel engine cylinder deactivation. The set of inactive and active cylinders varies on a cycle-by-cycle basis during dynamic cylinder activation. This enables greater control over forcing frequencies of the engine, thereby allowing the engine to operate away from the drivetrain resonant frequency at all engine speeds, while maintaining similar fuel savings, thermal management, and emission characteristics as fixed cylinder deactivation. Additional benefits of dynamic cylinder activation include a reduction in the consecutive number of cycles a given cylinder is deactivated, and more even cylinder usage. Enablement of engine operation without exciting drivetrain resonant frequencies at similar fuel efficiency and emissions as fixed cylinder deactivation makes dynamic cylinder activation a strong candidate to augment the benefits already demonstrated for fixed cylinder deactivation.