2008
DOI: 10.1073/pnas.0802042105
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Poxvirus ankyrin repeat proteins are a unique class of F-box proteins that associate with cellular SCF1 ubiquitin ligase complexes

Abstract: F-box proteins direct the degradation of an extensive range of proteins via the ubiquitin-proteasome system. Members of this large family of proteins are typically bipartite. They recruit specific substrates through a substrate-binding domain and, via the F-box, link these to core components of a major class of ubiquitin ligases (SCF1). F-box proteins thus determine the specificity of SCF1-mediated ubiquitination. F-box-like motifs were recently detected in poxvirus ankyrin repeat (ANK) proteins but clear comp… Show more

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Cited by 87 publications
(125 citation statements)
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“…This observation implies functions carried out mainly outside the factories. The latter conjecture is supported by the previous findings indicating that ankyrin repeat-containing proteins in vaccinia virus (39) and in Paramecium bursaria chlorella virus 1 (PBCV-1) virus (40) are involved in ubiquitination of host proteins in the host cytoplasm. This finding substantiates the notion suggested above that protein regulation through protein degradation is a crucial process throughout viral infection both inside and outside the viral factories.…”
Section: Resultssupporting
confidence: 65%
“…This observation implies functions carried out mainly outside the factories. The latter conjecture is supported by the previous findings indicating that ankyrin repeat-containing proteins in vaccinia virus (39) and in Paramecium bursaria chlorella virus 1 (PBCV-1) virus (40) are involved in ubiquitination of host proteins in the host cytoplasm. This finding substantiates the notion suggested above that protein regulation through protein degradation is a crucial process throughout viral infection both inside and outside the viral factories.…”
Section: Resultssupporting
confidence: 65%
“…G1R belongs to a larger poxvirus family of ANK repeat proteins that also contain a C-terminal F-box like domain [AKA; Pox proteins Repeats of ANkyrin -C-terminal (PRANC)] known to be necessary for interaction with components of the SCF (Skp1, culin-1 and F-box) complex (23,24). An ortholog search among the Poxvirus Bioinformatics Resource (PBR) proteins indicated that although G1R protein is substantially divergent from any vaccinia counterparts; it is highly conserved among several other pathogenic orthopoxvirus (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…However, no viral protein has been shown to interact directly with NF-B1/p105, categorizing the G1R family of proteins as unique NF-B inhibitors. Given that the ANK repeat domain has not been reported to occur within cellular F-box proteins, it has been suggested that poxviruses use these ANK/F-box proteins to dictate target specificity to SCF1 ubiquitin ligases and thereby exploit the cell's ubiquitin-proteasome machinery to target specific host proteins for elimination (24,28). However, the ability of a transiently expressed G1R family protein to inhibit the nuclear translocation of NF-B p65 suggests that the interaction between G1R and NF-B1/p105 might instead be interfering with the processing/degradation of NF-B1/p105, there- fore preventing the release of active NF-B p50 and the formation of the active NF-B p65/p50 heterodimer that subsequently translocates to the nucleus.…”
Section: Resultsmentioning
confidence: 99%
“…The ORFV ANK/F-box proteins (ORFs 008,123,126,128 and 129) have been shown to be functionally active, interacting with components of the cellular SCF ubiquitin ligase complex via their F-box-like domains (Sonnberg et al, 2008). Cellular F-box proteins facilitate protein degradation via the ubiquitin-proteasome pathway (Ho et al, 2008;Zhang et al, 2009), raising the possibility that poxvirus ANK/F-box proteins direct the removal of unwanted host cell proteins in order to favour viral replication.…”
Section: Hautaniemi and Othersmentioning
confidence: 99%
“…Cellular F-box proteins facilitate protein degradation via the ubiquitin-proteasome pathway (Ho et al, 2008;Zhang et al, 2009), raising the possibility that poxvirus ANK/F-box proteins direct the removal of unwanted host cell proteins in order to favour viral replication. Inhibitory roles in ubiquitination pathways are also possible (Mercer et al, 2005;Sonnberg et al, 2008;Zhang et al, 2009). Other poxvirus ANK/F-box proteins have been shown to inhibit virus-induced apoptosis (Ink et al, 1995;Mossman et al, 1996) and to influence virus virulence (Mossman et al, 1996;Wang et al, 2006), hostrange and tissue tropism (Shchelkunov et al, 1993;Ink et al, 1995;Johnston et al, 2005).…”
Section: Hautaniemi and Othersmentioning
confidence: 99%