[PP.05.34] Metabolic Syndrome-Related Features in Controlled and Resistant Hypertensive Subjects

Catharina, Arthur Santa; Modolo, Rodrigo; Ritter, Alessandra Mileni Versuti; Sabbatini, A.; Corrêa, Nicholas Kluge; Brunelli, V.; Fraccaro, N.; Almeida, Angélica; Lopes, Heno Ferreira; Moreno, Hugo Velázquez; Faria, Ana Paula de

doi:10.1097/01.hjh.0000523331.32573.33

Cited by 2 publications

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“…As demonstrated in experimental studies in human cells models, leptin also induces endothelial oxidative stress and reactive oxygen species formation [31,32], mechanisms known to increase the risk to develop hypertension. The increased level of leptin is often associated with hypoadiponectinemia [33]: visceral fat, in particular, has also been shown to be negatively associated with adiponectin levels, whose protective effect on arteries is known [34].…”

Section: Mechanisms Linking Obesity To Hypertensionmentioning

confidence: 99%

Weight Loss and Hypertension in Obese Subjects

et al. 2019

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Arterial hypertension is strongly related to overweight and obesity. In obese subjects, several mechanisms may lead to hypertension such as insulin and leptin resistance, perivascular adipose tissue dysfunction, renal impairment, renin-angiotensin-aldosterone-system activation and sympathetic nervous system activity. Weight loss (WL) seems to have positive effects on blood pressure (BP). The aim of this review was to explain the mechanisms linking obesity and hypertension and to evaluate the main studies assessing the effect of WL on BP. We analysed studies published in the last 10 years (13 studies either interventional or observational) showing the effect of WL on BP. Different WL strategies were taken into account—diet and lifestyle modification, pharmacological intervention and bariatric surgery. Although a positive effect of WL could be identified in each study, the main difference seems to be the magnitude and the durability of BP reduction over time. Nevertheless, further follow-up data are needed: there is still a lack of evidence about long term effects of WL on hypertension. Hence, given the significant results obtained in several recent studies, weight management should always be pursued in obese patients with hypertension.

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Section: Mechanisms Linking Obesity To Hypertensionmentioning

confidence: 99%

Weight Loss and Hypertension in Obese Subjects

et al. 2019

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“…Furthermore, the function of Lep in promoting the angiogenesis, activating the immune system, increasing the platelet aggregation, producing radical oxygen species (ROS) [57], inducing endothelial oxidative stress and ROS in experimental human cell models [58] interactively present a mechanism whereby risk of the development of HT increases. Adiponectin having protective effects on arteries associates negatively with Lep, and hence hypoadiponectinemia associates with increased Lep levels [59].…”

Section: Discussionmentioning

confidence: 99%

Interplay of Serum Leptin, Tumor Necrosis Factor Alpha, and Testosterone in Overweight-Related Hypertensive Men

Alaamri,

Serafi,

Hussain

et al. 2023

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Hypertension (HT) is a very common risk factor and a frequent cause of morbidity and mortality worldwide mainly due to much increase in overweight (OW) and obesity that manifests in various forms of cardiovascular disease (CVD). There are a number of factors that may cause overweight hypertension (OHT). However, we planned to conduct the present work to study the HT and OHT men for finding the variation, interrelationship and association of important cytokines mainly serum leptin (Lep) and tumor necrosis factor-alpha (TNF-α), serum testosterone (ST), total cholesterol (TC) and inflammatory status by measuring interleukin-6 (IL-6). Three groups of subjects, the normal controls (NC; n:98; age range: 51-60 years), HT (n: 97; age range: 51-60 years) subjects, and OHT (n: 97; age range: 51-60 years) subjects were studied. Comparisons for Lep, ST, TNF-α, IL-6 and TC levels for the subject groups showed significant variations. The ST indicated significant difference only for NC vs. OHT. The IL-6 gave significant difference for NC vs. OHT and HT vs. OHT. The one-way ANOVA showed significant difference among groups for BMI, TC, IL-6, TNF-α, ST and Lep levels. Significant positive linear correlation for all groups among Lep, TNF-α, IL-6 and TC were found. The ST against TC for HT and OHT groups presented non-significant negative linear correlations. The ST showed significant negative linear correlation with other variables. Conclusively, the present study uncovers the interactive impact of serum leptin, TNF-α, testosterone, total cholesterol and IL-6 in hypertensive and overweight-related hypertensive men.

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[PP.05.34] Metabolic Syndrome-Related Features in Controlled and Resistant Hypertensive Subjects

Cited by 2 publications

References 0 publications

Weight Loss and Hypertension in Obese Subjects

Weight Loss and Hypertension in Obese Subjects

Interplay of Serum Leptin, Tumor Necrosis Factor Alpha, and Testosterone in Overweight-Related Hypertensive Men

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