PP.38.14

Abstract

Results:The patients' age was 37.0 ± 15.0 years (20-76). NYHA class of the patients was I: 68, II: 25, III: 7, IV: 0. Sixteen patients were suffered from cyanosis (SpO2 < 95%) and their brain natriuretic peptide (BNP) level was 69.7 ± 152.5 pg/ml. The systolic BP was 117.7 ± 20.1 mmHg. Thirteen patients were diagnosed as hypertension. Twenty patients were defined as high systolic BP (20%). Using univariate analysis, the high systolic BP was associated with age (t = 3.452; p = 0.0021), body mass index (2.517; 0.0183), the level of BNP (-2.506; 0.0139), hemoglobin A1c (2.273; 0.0348), low-density lipoprotein cholesterol (4.392; 0.0002), total cholesterol (4.384; 0.0002) and triglyceride (3.185; 0.0047). Logistic regression analysis showed that the determinants of high systolic BP were age (odds ratio, 1.091; 95% confidence interval, 1.028-1.158; p = 0.004) and body mass index (1.230; 1.026-1.476; 0.025). Conclusions:The incidence of high systolic BP increases with aging in adult patients with CHD in comparison to general population. Early intervention would be essential in order to avoid increment of pressure load for systemic ventricle that has been variously loaded from birth. Objective:To explore the association between childhood risk factors and arterial stiffness in adulthood. Design and method:A baseline survey was carried out in 4623 school children aged 6-15 years in rural areas of Hanzhong city, Shaanxi in 1987. According to three measurements of systolic blood pressure (SBP) in 1987(SBP) in ,1989(SBP) in and 1992, high blood pressure group (HBP group) was defined as SBP equal or more than 75 percentile at same age and gender, with SBP < 50 percentile as normal blood pressure group (NBP group). The cohort were followed up again 26-years later(in 2013), At the same time, Blood biochemistry indexes were measured, including fasting glucose, uric acid and blood lipid. Brachial-ankle pulse wave velocity (baPWV) was recorded by noninvasive automatic waveform analyzer. Results:The follow-up rate was 71.6%. HBP group versus NBP group had higher incidence of hypertension (39.5% vs.18.0%, P = 0.001) and baPWV [(1337.2 ± 198.3) vs. (1271.7 ± 204.3) cm/s, P = 0.028] in this follow-up period. Correlation analysis indicated that the follow-up baPWV was positively correlated with childhood SBP and SBP, DBP, body mass index, heart rate, TC, LDL-C, TG, fasting glucose, uric acid in adulthood (all P < 0.05). In stepwise multivariate regression analysis, gender, family history of hypertension, SBP at both baseline and follow-up, fasting glucose and uric acid in adulthood were independent predictive factors of baPWV in adults. Conclusions:Higher SBP in children and adolescents, family history of hypertension and male gender may increase the risk of developing long-term arterial stiffness.Objective: To investigate salt (sodium) and potassium (K) intakes and sodium (Na)/K ratios by 24 hours urine collection (24U) and to compare results in junior high (JH) school students in India and Japan. Design and method:We conducted the...