Pp021-Sun Randomized Controlled Trial in Care Home Residents Shows Improved Quality of Life (Qol) With Oral Nutritional Supplements

Parsons, E.L.; Stratton, R.J.; Cawood, A.L.; Smith, T.R.; Warwick, Hilary M. C.; Elia, M.

doi:10.1016/s1744-1161(11)70075-8

Cited by 3 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Effective management of faltering growth requires the provision of optimal energy, protein and micronutrients important for growth [ 21 ], and nutrition support strategies can include dietary advice, food fortification and the use of ONS. There is significant evidence supporting the use of ONS, particularly in adults [ 5 – 7 , 10 , 13 , 17 , 18 , 26 , 38 , 39 , 41 , 42 , 45 , 47 – 51 ], but also in children [ 1 , 4 , 12 , 15 , 19 – 21 , 24 , 25 , 31 , 33 , 34 , 36 , 43 , 49 , 53 ], showing improved nutrient intakes, weight, quality of life, and reduced hospital admissions and readmissions, complications and healthcare costs. However, there is a lack of evidence for the use of ONS in the general faltering growth population and for the use of ready-made (liquid) ONS.…”

Section: Discussionmentioning

confidence: 99%

Energy-dense, low-volume paediatric oral nutritional supplements improve total nutrient intake and increase growth in paediatric patients requiring nutritional support: results of a randomised controlled pilot trial

et al. 2020

View full text Add to dashboard Cite

Children with or at risk of faltering growth require nutritional support and are often prescribed oral nutritional supplements (ONS). This randomised controlled trial investigated the effects of energy-dense paediatric ONS (2.4 kcal/ml, 125 ml: cONS) versus 1.5 kcal/ml, 200 ml ONS (sONS) in community-based paediatric patients requiring oral nutritional support. Fifty-one patients (mean age 5.8 years (SD 3)) with faltering growth and/or requiring ONS to meet their nutritional requirements were randomised to cONS (n = 27) or sONS (n = 24) for 28 days. Nutrient intake, growth, ONS compliance and acceptability, appetite and gastro-intestinal tolerance were assessed. Use of the cONS resulted in significantly greater mean total daily energy (+ 531 kcal/day), protein (+ 10.1 g/day) and key micronutrient Preliminary findings of this study have previously been presented at 4th International Conference on Nutrition and Growth, Amsterdam 2017 as Sorensen et al. Improved compliance, nutritional intakes and growth with a high energy density, low volume paediatric oral nutritional supplement (http://2017.nutrition-growth.kenes.com/abstract-submission/2016abstract-book#.WMq_FtJ95hF) Communicated by Mario Bianchetti

show abstract

Section: Discussionmentioning

confidence: 99%

Energy-dense, low-volume paediatric oral nutritional supplements improve total nutrient intake and increase growth in paediatric patients requiring nutritional support: results of a randomised controlled pilot trial

et al. 2020

View full text Add to dashboard Cite

show abstract

Dietary advice with or without oral nutritional supplements for disease-related malnutrition in adults

Baldwin

Schueren

Kruizenga

et al. 2021

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

Oral nutritional interventions in frail older people who are malnourished or at risk of malnutrition: a systematic review

Thomson

Rice

Arisa

et al. 2022

Health Technol Assess

View full text Add to dashboard Cite

Background Malnutrition worsens the health of frail older adults. Current treatments for malnutrition may include prescribed oral nutritional supplements, which are multinutrient products containing macronutrients and micronutrients. Objective To assess the effectiveness and cost-effectiveness of oral nutritional supplements (with or without other dietary interventions) in frail older people who are malnourished or at risk of malnutrition. Data sources MEDLINE, EMBASE, Cochrane Library, Scopus, CINAHL (Cumulative Index to Nursing and Allied Health Literature) and grey literature were searched from inception to 13 September 2021. Review methods A systematic review and meta-analysis was conducted to evaluate the effectiveness and cost-effectiveness of oral nutritional supplements in frail older people (aged ≥ 65 years) who are malnourished or at risk of malnutrition (defined as undernutrition as per National Institute for Health and Care Excellence guidelines). Meta-analysis and network meta-analysis were undertaken, where feasible, along with a narrative synthesis. A cost-effectiveness review was reported narratively. A de novo model was developed using effectiveness evidence identified in the systematic review to estimate the cost-effectiveness of oral nutritional supplements. Results Eleven studies (n = 822 participants) were included in the effectiveness review, six of which were fully or partly funded by industry. Meta-analyses suggested positive effects of oral nutritional supplements compared with standard care for energy intake (kcal) (standardised mean difference 1.02, 95% confidence interval 0.15 to 1.88; very low quality evidence) and poor mobility (mean difference 0.03, p < 0.00001, 95% confidence interval 0.02 to 0.04; very low quality evidence) but no evidence of an effect for body weight (mean difference 1.31, 95% confidence interval –0.05 to 2.66; very low quality evidence) and body mass index (mean difference 0.54, 95% confidence interval –0.03 to 1.11; very low quality evidence). Pooled results for other outcomes were statistically non-significant. There was mixed narrative evidence regarding the effect of oral nutritional supplements on quality of life. Network meta-analysis could be conducted only for body weight and grip strength; there was evidence of an effect for oral nutritional supplements compared with standard care for body weight only. Study quality was mixed; the randomisation method was typically poorly reported. One economic evaluation, in a care home setting, was included. This was a well-conducted study showing that oral nutritional supplements could be cost-effective. Cost-effectiveness analysis suggested that oral nutritional supplements may only be cost-effective for people with lower body mass index (< 21 kg/m2) using cheaper oral nutritional supplements products that require minimal staff time to administer. Limitations The review scope was narrow in focus as few primary studies used frailty measures (or our proxy criteria). This resulted in only 11 included studies. The small evidence base and varied quality of evidence meant that it was not possible to determine accurate estimates of the effectiveness or cost-effectiveness of oral nutritional supplements. Furthermore, only English-language publications were considered. Conclusions Overall, the review found little evidence of oral nutritional supplements having significant effects on reducing malnutrition or its adverse outcomes in frail older adults. Future work Future research should focus on independent, high-quality, adequately powered studies to investigate oral nutritional supplements alongside other nutritional interventions, with longer-term follow-up and detailed analysis of determinants, intervention components and cost-effectiveness. Study registration This study is registered as PROSPERO CRD42020170906. Funding This project was funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 26, No. 51. See the NIHR Journals Library website for further project information.

show abstract

Pp021-Sun Randomized Controlled Trial in Care Home Residents Shows Improved Quality of Life (Qol) With Oral Nutritional Supplements

Cited by 3 publications

References 0 publications

Energy-dense, low-volume paediatric oral nutritional supplements improve total nutrient intake and increase growth in paediatric patients requiring nutritional support: results of a randomised controlled pilot trial

Energy-dense, low-volume paediatric oral nutritional supplements improve total nutrient intake and increase growth in paediatric patients requiring nutritional support: results of a randomised controlled pilot trial

Dietary advice with or without oral nutritional supplements for disease-related malnutrition in adults

Oral nutritional interventions in frail older people who are malnourished or at risk of malnutrition: a systematic review

Contact Info

Product

Resources

About